The Evolution of Schiller\u27s Thought on Freedom and Patriotism, with Special Reference to Die Rauber , Don Carlos , and Wilhelm Tell

I have chosen the topic, The Evolution of Schiller\u27s Thought on Freedom and Patriotism , with special reference to Die Rauber , Don Carlos , and Wilhelm Tell , because it seems to me to represent one of the most significant and basic phases of the general philosophy of Germany\u27s greatest dramatist. According to consensus of critical opinion, it was Schiller\u27s ardent love of freedom which motivated practically all of his plays. In the actual world about him, in the society of his times, he found little that seemed to him to make for his ideal of inner harmony

Controlling strategy through dialectical management

Abstract. Controlling strategy has been portrayed as a matter of managing tensions. But what are these tensions and how do they arise in firms? In this paper, organizational strategy is represented by a target operating model that is maintained by dialectical relationships between functional areas. Using a pragmatic constructivist framework, the functional areas may be conceptualised as specialised managerial topoi. Drawing on field work in the hospitality industry, the paper employs an actor-based research methodology to show that organizational tensions may develop out of conflicts between the different goals and logics associated with the various functional areas such as marketing, sales, revenue management and finance. Although there was evidence of accountants acting as custodians of the budgetary system, in some situations, other functional areas such as marketing or revenue management seemed to be the corporate policemen as they protected the corporate brand against unplanned price discounting or short term cost saving tactics. Rather than seeing functional specialisation as a disruptive obstacle to organizational coherence, the paper presents arguments and evidence which suggest that with the deployment of the principles of dialectical management, tensions between the different business functions can enhance strategic control and development

Direct Measurement of Periodic Electric Forces in Liquids

The electric forces acting on an atomic force microscope tip in solution have been measured using a microelectrochemical cell formed by two periodically biased electrodes. The forces were measured as a function of lift height and bias amplitude and frequency, providing insight into electrostatic interactions in liquids. Real-space mapping of the vertical and lateral components of electrostatic forces acting on the tip from the deflection and torsion of the cantilever is demonstrated. This method enables direct probing of electrostatic and convective forces involved in electrophoretic and dielectroforetic self-assembly and electrical tweezer operation in liquid environments

Oxidation and chemical state analysis of polycrystalline magnetron sputtered (Ti,Al)N films at ambient and liquid N-2 temperatures

In order to improve the functional properties of hard coatings, recent investigations have been directed towards Ti-N based multicomponent materials. The nitride (Ti, Al)N, in particular, with a Ti:Al ratio of 1:1 seems to be a promising alternative to the widely used TiN, exhibits better oxidation resistance and hence improved performance over that of TiN. (Ti, Al)N coatings were de sputter deposited onto 316SS substrates under ambient and liquid nitrogen temperatures. As deposited films were oxidized in a vertical fused-silica tube furnace in pure O-2 flowing atmosphere at temperatures ranging from 700 to 900 degrees C. Scanning electron microscope and atomic force microscope images reveal information about the particle size and film thickness. X-ray photoelectron spectroscopy was employed to study the chemistry of the cop few atomic layers in addition to compositional analysis and information on the details of chemical bonding, The difference in film stoichiometry are compared at two different deposition conditions thus reflecting their behavior under oxidizing conditions

Agent-based dynamic knowledge representation of Pseudomonas aeruginosa virulence activation in the stressed gut: Towards characterizing host-pathogen interactions in gut-derived sepsis

<p>Abstract</p> <p>Background</p> <p>There is a growing realization that alterations in host-pathogen interactions (HPI) can generate disease phenotypes without pathogen invasion. The gut represents a prime region where such HPI can arise and manifest. Under normal conditions intestinal microbial communities maintain a stable, mutually beneficial ecosystem. However, host stress can lead to changes in environmental conditions that shift the nature of the host-microbe dialogue, resulting in escalation of virulence expression, immune activation and ultimately systemic disease. Effective modulation of these dynamics requires the ability to characterize the complexity of the HPI, and dynamic computational modeling can aid in this task. Agent-based modeling is a computational method that is suited to representing spatially diverse, dynamical systems. We propose that dynamic knowledge representation of gut HPI with agent-based modeling will aid in the investigation of the pathogenesis of gut-derived sepsis.</p> <p>Methodology/Principal Findings</p> <p>An agent-based model (ABM) of virulence regulation in <it>Pseudomonas aeruginosa </it>was developed by translating bacterial and host cell sense-and-response mechanisms into behavioral rules for computational agents and integrated into a virtual environment representing the host-microbe interface in the gut. The resulting gut milieu ABM (GMABM) was used to: 1) investigate a potential clinically relevant laboratory experimental condition not yet developed - i.e. non-lethal transient segmental intestinal ischemia, 2) examine the sufficiency of existing hypotheses to explain experimental data - i.e. lethality in a model of major surgical insult and stress, and 3) produce behavior to potentially guide future experimental design - i.e. suggested sample points for a potential laboratory model of non-lethal transient intestinal ischemia. Furthermore, hypotheses were generated to explain certain discrepancies between the behaviors of the GMABM and biological experiments, and new investigatory avenues proposed to test those hypotheses.</p> <p>Conclusions/Significance</p> <p>Agent-based modeling can account for the spatio-temporal dynamics of an HPI, and, even when carried out with a relatively high degree of abstraction, can be useful in the investigation of system-level consequences of putative mechanisms operating at the individual agent level. We suggest that an integrated and iterative heuristic relationship between computational modeling and more traditional laboratory and clinical investigations, with a focus on identifying useful and sufficient degrees of abstraction, will enhance the efficiency and translational productivity of biomedical research.</p