Bethe ansatz solution of the anisotropic correlated electron model associated with the Temperley-Lieb algebra

A recently proposed strongly correlated electron system associated with the Temperley-Lieb algebra is solved by means of the coordinate Bethe ansatz for periodic and closed boundary conditions.Comment: 21 page

Renormalization group trajectories from resonance factorized S-matrices

We propose and investigate a large class of models possessing resonance factorized S-matrices. The associated Casimir energy describes a rich pattern of renormalization group trajectories related to flows in the coset models based on the simply laced Lie Algebras. From a simplest resonance S-matrix, satisfying the ``$\phi^3$-property'', we predict new flows in non-unitary minimal models.Comment: (7 pages) (no figures included

Jorge A. Swieca's contributions to quantum field theory in the 60s and 70s and their relevance in present research

After revisiting some high points of particle physics and QFT of the two decades from 1960 to 1980, I comment on the work by Jorge Andre Swieca. I explain how it fits into the quantum field theory during these two decades and draw attention to its relevance to the ongoing particle physics research. A particular aim of this article is to direct thr readers mindfulness to the relevance of what at the time of Swieca was called "the Schwinger Higgs screening mechanism". which, together with recent ideas which generalize the concept of gauge theories, has all the ingredients to revolutionize the issue of gauge theories and the standard model.Comment: 49 pages, expansion and actualization of text, improvement of formulations and addition of many references to be published in EPJH - Historical Perspectives on Contemporary Physic

On scaling fields in ZNZ_N Ising models

We study the space of scaling fields in the $Z_N$ symmetric models with the factorized scattering and propose simplest algebraic relations between form factors induced by the action of deformed parafermionic currents. The construction gives a new free field representation for form factors of perturbed Virasoro algebra primary fields, which are parafermionic algebra descendants. We find exact vacuum expectation values of physically important fields and study correlation functions of order and disorder fields in the form factor and CFT perturbation approaches.Comment: 2 Figures, jetpl.cl

Gene-specific repair of Pt/DNA lesions and induction of apoptosis by the oral platinum drug JM216 in three human ovarian carcinoma cell lines sensitive and resistant to cisplatin

JM216, an oral platinum drug entering into phase III clinical trial, exhibited comparable cytotoxicity to cisplatin in three human ovarian carcinoma cell lines: the sensitive (CH1), acquired resistant (CH1cisR) and intrinsically resistant (SKOV-3). Platinum accumulation and binding to DNA were similar in each of the three cell lines at equimolar doses, indicating that the resistant cell lines could tolerate higher intracellular platinum levels and platinum bound to DNA at IC50 concentrations of drug. Comparison with cisplatin demonstrated that intracellular platinum levels were marginally higher with JM216, but that platinum binding to DNA was similar for the two drugs in each of the cell lines. Each of the cell lines exhibited an ability to repair JM216 induced platinum/DNA lesions in the N-ras gene (gene-specific repair) at equitoxic concentrations of drug. However, this occurred to a greater extent in the two resistant cell lines such that by 24 h the CH1cisR and SKOV-3 had removed 72% and 67% respectively compared with approximately 32% for the CH1. Reduced gene-specific repair capacity in CH1 cells was also seen following incubation with 25 μM (or 5 μM – 2 × IC50) cisplatin, whereas the CH1cisR and SKOV-3 cell lines were repair proficient. JM216 induced apoptosis in the three cell lines following a 2h incubation with 2 × the IC50 of drug. Fluorescent microscopy of cells stained with propidium iodide showed that the detached cell population displayed typical apoptotic nuclei. Furthermore, field inversion gel electrophoresis demonstrated the presence of DNA fragments approximately 23–50 kb in size, indicative of apoptosis, in the detached cells. JM216 induced an S phase slow down in each of the three cell lines accompanied by a G2 block in the CH1 pair. Incubation with this concentration of JM216 also resulted in the induction of p53 in the CH1 and CH1cisR. These studies suggest that the relative sensitivity of the CH1 cell line to cisplatin and JM216 is at least partly attributable to a deficiency in gene-specific repair. The oral platinum drug, JM216, exerts its cytotoxic effects through the induction of apoptosis following a slow-down in S phase in both the sensitive and resistant lines. © 1999 Cancer Research Campaig

Integrable sigma models with theta=pi

A fundamental result relevant to spin chains and two-dimensional disordered systems is that the sphere sigma model with instanton coupling theta=pi has a non-trivial low-energy fixed point and a gapless spectrum. This result is extended to two series of sigma models with theta=pi: the SU(N)/SO(N) sigma models flow to the SU(N)_1 WZW theory, while the O(2N)/O(N)\times O(N) models flow to O(2N)_1 (2N free Majorana fermions). These models are integrable, and the exact quasiparticle spectra and S matrices are found. One interesting feature is that charges fractionalize when theta=pi. I compute the energy in a background field, and verify that the perturbative expansions for \theta=0 and pi are the same as they must be. I discuss the flows between the two sequences of models, and also argue that the analogous sigma models with Sp(2N) symmetry, the Sp(2N)/U(N) models, flow to Sp(2N)_1.Comment: 31 pages, 2 figures. v2: corrects many typos. v3: corrects more typos, adds referenc

Bacteria Modulate the CD8+ T Cell Epitope Repertoire of Host Cytosol-Exposed Proteins to Manipulate the Host Immune Response

The main adaptive immune response to bacteria is mediated by B cells and CD4+ T-cells. However, some bacterial proteins reach the cytosol of host cells and are exposed to the host CD8+ T-cells response. Both gram-negative and gram-positive bacteria can translocate proteins to the cytosol through type III and IV secretion and ESX-1 systems, respectively. The translocated proteins are often essential for the bacterium survival. Once injected, these proteins can be degraded and presented on MHC-I molecules to CD8+ T-cells. The CD8+ T-cells, in turn, can induce cell death and destroy the bacteria's habitat. In viruses, escape mutations arise to avoid this detection. The accumulation of escape mutations in bacteria has never been systematically studied. We show for the first time that such mutations are systematically present in most bacteria tested. We combine multiple bioinformatic algorithms to compute CD8+ T-cell epitope libraries of bacteria with secretion systems that translocate proteins to the host cytosol. In all bacteria tested, proteins not translocated to the cytosol show no escape mutations in their CD8+ T-cell epitopes. However, proteins translocated to the cytosol show clear escape mutations and have low epitope densities for most tested HLA alleles. The low epitope densities suggest that bacteria, like viruses, are evolutionarily selected to ensure their survival in the presence of CD8+ T-cells. In contrast with most other translocated proteins examined, Pseudomonas aeruginosa's ExoU, which ultimately induces host cell death, was found to have high epitope density. This finding suggests a novel mechanism for the manipulation of CD8+ T-cells by pathogens. The ExoU effector may have evolved to maintain high epitope density enabling it to efficiently induce CD8+ T-cell mediated cell death. These results were tested using multiple epitope prediction algorithms, and were found to be consistent for most proteins tested