Correcting cold wire measurements in isotropic turbulence with a DNS database

We estimate the effect of the finite spatial resolution of a cold wire for scalar measurements, using a database from direct numerical simulations (DNS). These are for homogeneous isotropic turbulence at low Taylor-microscale Reynolds number (≃ 42) and Schmidt number unity. Correction factors for the scalar variance, scalar mean dissipation rate, and mixed velocity-scalar derivative skewness are evaluated, for a sensor length of up to 15 times the Batchelor length scale. The largest attenuation effect is found on the dissipation rate, followed by the scalar variance. The mixed skewness,which is affected the least, is overestimated

Cloud microphysical effects of turbulent mixing and entrainment

Turbulent mixing and entrainment at the boundary of a cloud is studied by means of direct numerical simulations that couple the Eulerian description of the turbulent velocity and water vapor fields with a Lagrangian ensemble of cloud water droplets that can grow and shrink by condensation and evaporation, respectively. The focus is on detailed analysis of the relaxation process of the droplet ensemble during the entrainment of subsaturated air, in particular the dependence on turbulence time scales, droplet number density, initial droplet radius and particle inertia. We find that the droplet evolution during the entrainment process is captured best by a phase relaxation time that is based on the droplet number density with respect to the entire simulation domain and the initial droplet radius. Even under conditions favoring homogeneous mixing, the probability density function of supersaturation at droplet locations exhibits initially strong negative skewness, consistent with droplets near the cloud boundary being suddenly mixed into clear air, but rapidly approaches a narrower, symmetric shape. The droplet size distribution, which is initialized as perfectly monodisperse, broadens and also becomes somewhat negatively skewed. Particle inertia and gravitational settling lead to a more rapid initial evaporation, but ultimately only to slight depletion of both tails of the droplet size distribution. The Reynolds number dependence of the mixing process remained weak over the parameter range studied, most probably due to the fact that the inhomogeneous mixing regime could not be fully accessed when phase relaxation times based on global number density are considered.Comment: 17 pages, 10 Postscript figures (figures 3,4,6,7,8 and 10 are in reduced quality), to appear in Theoretical Computational Fluid Dynamic

Relative role of short interfacial fingers and long internally driven streamers in convective flows below growing sea ice

Convective dynamics developing below growing sea ice are studied experimentally by freezing salt water from above in a quasi-two-dimensional Hele-Shaw cell. Observations of the convective processes are made with Schlieren and direct imaging systems, allowing visualization both under and within the growing ice. Buoyancy-driven flows are seen to develop under the ice layer via two different mechanisms: On one hand, brine diffuses out from the ice layer creating a denser boundary layer of enhanced salinity, which triggers boundary layer convection resulting in small-scale interfacial fingers. On the other hand, internal flow within brine drainage channels inside the ice is observed flushing out longer-scale convective streamers at given locations at the ice-water interface. Streamers descend in the bulk aqueous layer faster and for longer distances than fingers. Simulations confirm that, despite nonlinear interactions between fingers and streamers, the different speeds observed can be correlated to different density differences between the interfacial or internal rejection and the underlying bulk salt water. Estimates of relative mass fluxes through the interface by the two mechanisms suggest that, when streamers are active, the mass of salt rejected through the streamer pathway can be larger than the one expelled through the finger pathway. However, as fingers are maintained throughout the ice growth while the rejection from brine channels features an intermittent "on-off" behavior, there are certain periods of time when the mass flux of the two mechanisms is similar, but also some time intervals during which the flux due to interfacial short fingers becomes dominant.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Modulators of Cytoskeletal Reorganization in CA1 Hippocampal Neurons Show Increased Expression in Patients at Mid-Stage Alzheimer's Disease

During the progression of Alzheimer's disease (AD), hippocampal neurons undergo cytoskeletal reorganization, resulting in degenerative as well as regenerative changes. As neurofibrillary tangles form and dystrophic neurites appear, sprouting neuronal processes with growth cones emerge. Actin and tubulin are indispensable for normal neurite development and regenerative responses to injury and neurodegenerative stimuli. We have previously shown that actin capping protein beta2 subunit, Capzb2, binds tubulin and, in the presence of tau, affects microtubule polymerization necessary for neurite outgrowth and normal growth cone morphology. Accordingly, Capzb2 silencing in hippocampal neurons resulted in short, dystrophic neurites, seen in neurodegenerative diseases including AD. Here we demonstrate the statistically significant increase in the Capzb2 expression in the postmortem hippocampi in persons at mid-stage, Braak and Braak stage (BB) III-IV, non-familial AD in comparison to controls. The dynamics of Capzb2 expression in progressive AD stages cannot be attributed to reactive astrocytosis. Moreover, the increased expression of Capzb2 mRNA in CA1 pyramidal neurons in AD BB III-IV is accompanied by an increased mRNA expression of brain derived neurotrophic factor (BDNF) receptor tyrosine kinase B (TrkB), mediator of synaptic plasticity in hippocampal neurons. Thus, the up-regulation of Capzb2 and TrkB may reflect cytoskeletal reorganization and/or regenerative response occurring in hippocampal CA1 neurons at a specific stage of AD progression

Anisotrophy of magnetohydrodynamic turbulence at low magnetic Reynolds number

Turbulent fluctuations in magnetohydrodynamic flows are known to become anisotropic under the action of a sufficiently strong magnetic field. We investigate this phenomenon in the case of low magnetic Reynolds number using direct numerical simulations and large eddy simulations of a forced flow in a periodic box. A series of simulations is performed with different strengths of the magnetic field, varying Reynolds number, and two types of forcing, one of which is isotropic and the other limited to two-dimensional flow modes. We find that both the velocity anisotropy (difference in the relative amplitude of the velocity components) and the anisotropy of the velocity gradients are predominantly determined by the value of the magnetic interaction parameter. The effects of the Reynolds number and the type of forcing are much weaker. We also find that the anisotropy varies only slightly with the length scale. <br/

Mixed convection of a low Prandtl fluid with spatially periodic lower wall heating in the presence of a wall-normal magnetic field

Numerical simulations of the combined natural and forced convection flow in a horizontal channel have been carried out for a fluid of low Prandtl number in the presence of a uniform wall-normal magnetic field. The upper wall is maintained at a constant temperature, while a spatially periodic temperature is imposed at the lower wall. A stability diagram is created based on the results from two- and three-dimensional numerical simulations in order to examine whether the present two-dimensional flows are unstable to three-dimensional disturbances. At the range of parameters studied (5000 <= Ra <= 150,000-Rayleigh number, 5 <= Re <= 500-Reynolds number, and 0 <= Ha <= 20-Hartmann number), no stable two-dimensional unsteady flow is observed. All mixed convection flows are suppressed by the action of sufficiently strong electromagnetic forces and, in contrast to the hydrodynamic cases, the direct transition to unsteadiness is favored with an apparent lack of steady three-dimensional magnetohydrodynamic flows. The velocity and temperature features of the various flow regimes are discussed, addressing also the differences in the predictions produced by the two- and three-dimensional numerical simulations. (C) 2014 Elsevier Ltd. All rights reserved

MHD Turbulence at Moderate Magnetic Reynolds Number

In the present article we will consider the decay of MHD turbulence under the influence of a strong external magnetic field at moderate magnetic Reynolds numbers. Typical values of R(sub m) that are considered here range from R(sub m) approx. 0.1 to R(sub m) approx. 20. As a comparison, the initial kinetic Reynolds number common to all our simulations is Re(sub L) = 199. This means that the range of Prandtl numbers explored is 5 x 10(exp -4) to 10(exp -1). Our motivation is mainly to exhibit how the transition from the QS approximation to FMHD occurs. At the lowest values of R(sub m) studied here, the QS approximation is shown to model the flow faithfully. However, for the higher values of R(sub m) considered, it is clearly inadequate but can be replaced by another approximation which will be referred to as the Quasi-Linear (QL) approximation. Another objective of the present study is to describe how variations in the magnetic Reynolds number (while maintaining all other parameters constant) affect the dynamics of the flow. This complements past studies where variations in either the strength of the external magnetic field or the kinetic Reynolds number were considered. This article is organized as follows. In section 2 we recall the definition of the quasi-static approximation. Section 3 is devoted to the description of the numerical experiments performed using the quasi-static approximation and full MHD. In section 4 we describe the quasi-linear approximation and test it numerically against full MHD. A concluding summary is given in section 5