Ajitts: adaptive just-in-time transaction scheduling

Lecture Notes in Computer Science 7891, 2013Distributed transaction processing has benefited greatly from optimistic concurrency control protocols thus avoiding costly fine-grained synchronization. However, the performance of these protocols degrades significantly when the workload increases, namely, by leading to a substantial amount of aborted transactions due to concurrency conflicts. Our approach stems from the observation that when the abort rate increases with the load as already executed transactions queue for longer periods of time waiting for their turn to be certified and committed. We thus propose an adaptive algorithm for judiciously scheduling transactions to minimize the time during which these are vulnerable to being aborted by concurrent transactions, thereby reducing the overall abort rate. We do so by throttling transaction execution using an adaptive mechanism based on the locally known state of globally executing transactions, that includes out-of-order execution. Our evaluation using traces from the industry standard TPC-E workload shows that the amount of aborted transactions can be kept bounded as system load increases, while at the same time fully utilizing system resources and thus scaling transaction processing throughput.(undefined

Processing Transactions over Optimistic Atomic Broadcast Protocols

Atomic broadcast primitives allow fault-tolerant cooperation between sites in adistributed system. Unfortunately, the delay incurred before a message can be delivered makes it difficult to implement high performance, scalable applications on top of atomic broadcast primitives. Recently, a new approach has been proposed which, based on optimistic assumptions about the communication system, reduces the average delay for message delivery. In this paper, we develop this idea further and present a replicated database architecture that employs the new atomic broadcast primitive in such a way that the coordination phase of the atomic broadcast is fully overlapped with th

Improving the scalability of cloud-based resilient database servers

Many rely now on public cloud infrastructure-as-a-service for database servers, mainly, by pushing the limits of existing pooling and replication software to operate large shared-nothing virtual server clusters. Yet, it is unclear whether this is still the best architectural choice, namely, when cloud infrastructure provides seamless virtual shared storage and bills clients on actual disk usage. This paper addresses this challenge with Resilient Asynchronous Commit (RAsC), an improvement to awell-known shared-nothing design based on the assumption that a much larger number of servers is required for scale than for resilience. Then we compare this proposal to other database server architectures using an analytical model focused on peak throughput and conclude that it provides the best performance/cost trade-off while at the same time addressing a wide range of fault scenarios

Two Cases of Cardiac Arteriovenous Malformation Complicated by a Local Angioproliferative Process

Vascular malformations of the heart are extremely rare with only a few cases of the arteriovenous type of vascular malformation (AVM) reported. We investigated the pathology of two additional cases, which were complicated by the occurrence of a local vasoproliferative response of immature but benign vessels. We suppose that the mass forming effect of this vasoproliferative response, which has also been reported recently as a complication of congenital AVM elsewhere in the body, has significantly contributed to the onset of symptoms and ultimate death of both patients

Intracoronary infusion of mononuclear cells after PCI-treated myocardial infarction and arrhythmogenesis: is it safe?

To reduce long-term morbidity after revascularised acute myocardial infarction, different therapeutic strategies have been investigated. Cell therapy with mononuclear cells from bone marrow (BMMC) or peripheral blood (PBMC) has been proposed to attenuate the adverse processes of remodelling and subsequent heart failure. Previous trials have suggested that cell therapy may facilitate arrhythmogenesis. In the present substudy of the HEBE cell therapy trial, we investigated whether intracoronary cell therapy alters the prevalence of ventricular arrhythmias after 1 month or the rate of severe arrhythmogenic events (SAE) in the first year. In 164 patients of the trial we measured function and infarct size with cardiovascular magnetic resonance (CMR) imaging. Holter registration was performed after 1 month from which the number of triplets (3 successive PVCs) and ventricular tachycardias (VT, ≥4 successive PVCs) was assessed. Thirty-three patients (20%) showed triplets and/or VTs, with similar distribution amongst the groups (triplets: control n = 8 vs. BMMC n = 9, p = 1.00; vs. PBMC n = 10, p = 0.67. VT: control n = 9 vs. BMMC n = 9, p = 0.80; vs. PBMC n = 11, p = 0.69). SAE occurred in 2 patients in the PBMC group and 1 patient in the control group. In conclusion, intracoronary cell therapy is not associated with an increase in ventricular arrhythmias or SAE

Nitrogen Excretion and Ammonia Emissions from Pigs Fed Modified Diets

Two swine feeding trials were conducted (initial body weight = 47 ± 2 and 41 ± 3 kg for Trials 1 and 2, respectively) to evaluate reduced crude protein (CP) and yucca (Yucca schidigera Roezl ex Ortgies) extract–supplemented diets on NH3 emissions. In Trial 1, nine pigs were offered a corn–soybean meal diet (C, 174 g kg−1 CP), a Lys-supplemented diet (L, 170 g kg−1 CP), or a 145 g kg−1 CP diet supplemented with Lys, Met, Thr, and Trp (LMTT). In Trial 2, nine pigs were fed diet L supplemented with 0, 62.5, or 125 mg of yucca extract per kg diet. Each feeding period consisted of a 4-d dietary adjustment followed by 72 h of continuous NH3 measurement. Urine and fecal samples were collected each period. Feeding the LMTT diet reduced (P \u3c 0.05) average daily gain (ADG) and feed efficiency (G:F) compared to diet L. Fecal N concentration decreased with a reduction in dietary CP, but urinary ammonium increased from pigs fed diet LMTT (2.0 g kg−1, wet basis) compared to those fed diet C (1.1 g kg−1) or L (1.0 g kg−1). When pigs were fed reduced CP diets NH3emission rates decreased (2.46, 2.16, and 1.05 mg min−1 for diets C, L, and LMTT). Yucca had no effect on feed intake, ADG, or G:F. Ammonium and N concentrations of manure and NH3 emission rates did not differ with yucca content. Caution must be executed to maintain animal performance when strategies are implemented to reduce NH3 emissions

First delivery of a COVID-19 positive patient in Cameroon

Since its appearance in China in December 2019, COVID-19 which is caused by the SARS-CoV-2 virus has become a real global health problem. Pregnant women are not immune to this novel infection, which makes it difficult for proper management of pregnancy and childbirth. Authors present here the first case of childbirth in Cameroon of a 19-year-old adolescent tested positive for COVID-19

Interobserver variability in target definition for stereotactic arrhythmia radioablation

BackgroundStereotactic arrhythmia radioablation (STAR) is a potential new therapy for patients with refractory ventricular tachycardia (VT). The arrhythmogenic substrate (target) is synthesized from clinical and electro-anatomical information. This study was designed to evaluate the baseline interobserver variability in target delineation for STAR.MethodsDelineation software designed for research purposes was used. The study was split into three phases. Firstly, electrophysiologists delineated a well-defined structure in three patients (spinal canal). Secondly, observers delineated the VT-target in three patients based on case descriptions. To evaluate baseline performance, a basic workflow approach was used, no advanced techniques were allowed. Thirdly, observers delineated three predefined segments from the 17-segment model. Interobserver variability was evaluated by assessing volumes, variation in distance to the median volume expressed by the root-mean-square of the standard deviation (RMS-SD) over the target volume, and the Dice-coefficient.ResultsTen electrophysiologists completed the study. For the first phase interobserver variability was low as indicated by low variation in distance to the median volume (RMS-SD range: 0.02–0.02 cm) and high Dice-coefficients (mean: 0.97 ± 0.01). In the second phase distance to the median volume was large (RMS-SD range: 0.52–1.02 cm) and the Dice-coefficients low (mean: 0.40 ± 0.15). In the third phase, similar results were observed (RMS-SD range: 0.51–1.55 cm, Dice-coefficient mean: 0.31 ± 0.21).ConclusionsInterobserver variability is high for manual delineation of the VT-target and ventricular segments. This evaluation of the baseline observer variation shows that there is a need for methods and tools to improve variability and allows for future comparison of interventions aiming to reduce observer variation, for STAR but possibly also for catheter ablation