915 research outputs found
Wound healing and anti-inflammatory activity of extract of Ficus racemosa linn. bark in albino rats
Background: F. racemosa is an indigenous plant having anti-secretory, anti-diabetic, anti-ulcer etc. properties. It is used widely in the ayurvedic medicines.Methods: The experimental models of wound and inflammation were used to assess the wound healing and anti-inflammatory properties of F. racemosa. The significance of differences was analyzed using students’ ‘t’ test.Results: In the strength of 10% local application it could apparently enhanced the process of healing. At the dose of 20 mg/100 gm intraperitoneally it could show inhibition of carageenan induced acute inflammation at 3rd, 5th and 7th hour and at the dose of 30 mg/100 gm intraperitoneally, formalin induced subacute inflammation was inhibited till 4th day. The results were found statistically significant.Conclusions: Aqueous extract of F. racemosa has got wound healing and anti-inflammatory activity. It is likely that the duration of action may be shorter
Approval of antineoplastic agents in India: comparison with the US and EU regions
Background: The antineoplastic drugs are prescribed for the treatment of cancer, which is an important cause of mortality in India; therefore, a drug lag in the availability of antineoplastic drugs is a direct threat to life. The present study was undertaken to assess the drug lag for new antineoplastic agents in India compared with that in the United States (US) or European Union (EU).Methods: The new antineoplastic agents approved in the United States, European Union and India between 1999 and 2011 were identified and information was gathered primarily from the websites of regulatory agencies of the three regions. We assessed absolute and relative drug lag for new antineoplastic agents approved in the three regions.Results: Of the 70 new antineoplastic agents, 64 (91.42%) were approved in the United States, 54 (77.14%) in the European Union and 44 (62.85%) in India. The US was the first to approve 59 (84.28%) out of the 70 new antineoplastic agents, the EU was the first to approve 9 (12.85%) and India was the first to approve 2 (2.85%). The median approval lag for India (26.35 months) was higher as compared to the United States (0 month) and European Union (7.3 months).Conclusions: This study confirms that India’s drug lag in the case of new antineoplastic agents is higher as compared to the US and EU. Further detailed analyses are necessary to find the reasons and impacts of drug lag for antineoplastic agents in India
Ivermectin: pharmacology and therapeutic applications
Ivermectin is an antiparasitic drug with a broad spectrum of activity, high efficacy as well as a wide margin of safety. It belongs to the family of avermectins. It binds to glutamate-gated chloride iron channels, which are present in invertebrate nerve and muscle cells, and causes the paralysis and death of the parasite. Ivermectin is approved by the US Food and Drug Administration, and used worldwide to treat patients with onchocerciasis and strongyloidiasis. It is also used against a wide range of endoparasites (nematodes) and ectoparasites (insects, acarine) of animals and humans
Unusual Esophageal Twin Foreign Body (Glass Marble) in a Neonate
Although ingestion of foreign body in oesophagus is common in pediatric age group, its occurrence in neonatal period is rare. Etiology behind these foreign bodies may be negligence or homicidal attempt for unwanted child. A high index of suspicion is required for diagnosis, whenever the neonate presents with symptoms related either to the respiratory or gastrointestinal tract. Delayed diagnosis can result in serious complications. We report a very unusual case of twin foreign body (glass marble) in oesophagus in a 30 days old female neonate. The peculiarity of this case concerns the unusual foreign body and age of the patient
Performance and simulated moment uncertainties of an ion spectrometer with asymmetric 2π field of view for ion measurements in space
Space plasma instruments provide 3D particle velocity distribution functions. Because of telemetry limitations, these cannot be transmitted in high time resolution and the plasma needs to be characterized by moments of the velocity distribution function. These moment uncertainties have vital effects on the reliability and accuracy of onboard plasma moments. We assess the measurement accuracy for magnetosheath and solar wind ions using an ion spectrometer with an asymmetric field of view designed for the all-sky measurement of low-energy ions in the magnetosheath and solar wind. We focus on moment uncertainties for the ideal spectrometer, not considering the background counts, which may have considerable effects on the uncertainties in real life. To obtain number density, bulk velocity, and temperature, different orders of moments are integrated assuming a Maxwellian velocity distribution. Based on the design specifications, we use simulations to estimate systematic and random errors for typical plasma conditions. We find that the spectrometer resolution is adequate for determining the density of solar wind (∼7% error) and magnetosheath ions (∼4% error). The resolution is also adequate for determining the temperature of solar wind (∼10% error) and magnetosheath ions (∼2% error). For high speed flows with a bulk velocity of 750 km/s and a temperature of 20 eV, the maximum density and temperature errors become 9% and 7%, respectively. The bulk velocity errors are less than 2% for all cases. The contributions of heavy ions to the systematic errors are less than 5% for magnetosheath ions and less than 8% for solar wind ions
Phase curves of WASP-33b and HD 149026b and a New Correlation Between Phase Curve Offset and Irradiation Temperature
We present new 3.6 and 4.5 Spitzer phase curves for the highly
irradiated hot Jupiter WASP-33b and the unusually dense Saturn-mass planet HD
149026b. As part of this analysis, we develop a new variant of pixel level
decorrelation that is effective at removing intrapixel sensitivity variations
for long observations (>10 hours) where the position of the star can vary by a
significant fraction of a pixel. Using this algorithm, we measure eclipse
depths, phase amplitudes, and phase offsets for both planets at 3.6 and
4.5 . We use a simple toy model to show that WASP-33b's phase offset,
albedo, and heat recirculation efficiency are largely similar to those of other
hot Jupiters despite its very high irradiation. On the other hand, our fits for
HD 149026b prefer a very high albedo and an unusually high recirculation
efficiency. We also compare our results to predictions from general circulation
models, and find that while neither are a good match to the data, the
discrepancies for HD 149026b are especially large. We speculate that this may
be related to its high bulk metallicity, which could lead to enhanced
atmospheric opacities and the formation of reflective cloud layers in localized
regions of the atmosphere. We then place these two planets in a broader context
by exploring relationships between the temperatures, albedos, heat transport
efficiencies, and phase offsets of all planets with published thermal phase
curves. We find a striking relationship between phase offset and irradiation
temperature--the former drops with increasing temperature until around 3400 K,
and rises thereafter. Although some aspects of this trend are mirrored in the
circulation models, there are notable differences that provide important clues
for future modeling efforts
The Very Low Albedo of WASP-12b From Spectral Eclipse Observations with
We present an optical eclipse observation of the hot Jupiter WASP-12b using
the Space Telescope Imaging Spectrograph on board the Hubble Space Telescope.
These spectra allow us to place an upper limit of (97.5%
confidence level) on the planet's white light geometric albedo across 290--570
nm. Using six wavelength bins across the same wavelength range also produces
stringent limits on the geometric albedo for all bins. However, our
uncertainties in eclipse depth are 40% greater than the Poisson limit and
may be limited by the intrinsic variability of the Sun-like host star --- the
solar luminosity is known to vary at the level on a timescale of
minutes. We use our eclipse depth limits to test two previously suggested
atmospheric models for this planet: Mie scattering from an aluminum-oxide haze
or cloud-free Rayleigh scattering. Our stringent nondetection rules out both
models and is consistent with thermal emission plus weak Rayleigh scattering
from atomic hydrogen and helium. Our results are in stark contrast with those
for the much cooler HD 189733b, the only other hot Jupiter with spectrally
resolved reflected light observations; those data showed an increase in albedo
with decreasing wavelength. The fact that the first two exoplanets with optical
albedo spectra exhibit significant differences demonstrates the importance of
spectrally resolved reflected light observations and highlights the great
diversity among hot Jupiters.Comment: 8 pages, 4 figures, 1 table, published in ApJL, in pres
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