2,915 research outputs found
Sulphur River Formation and the Pleistocene Mammals of the Ben Franklin Local Fauna
An extensive alluvial deposit in northeastern Texas is here described and named the Sulphur River Formation. Twenty-one mammals from these deposits are identified and grouped under the name Ben Franklin local fauna. Fossils and radiocarbon dates indicate that the age of the fauna is Late Wisconsin
Associations between implementation characteristics and evidence-based practice sustainment: a study of the Adolescent Community Reinforcement Approach
Driving calmodulin protein towards conformational shift by changing ionization states of select residues
Proteins are complex systems made up of many conformational sub-states which are mainly determined by the folded structure. External factors such as solvent type, temperature, pH and ionic strength play a very important role in the conformations sampled by proteins. Here we study the conformational multiplicity of calmodulin (CaM) which is a protein that plays an important role in calcium signaling pathways in the eukaryotic cells. CaM can bind to a variety of other proteins or small organic compounds, and mediates different physiological processes by activating various enzymes. Binding of calcium ions and proteins or small organic molecules to CaM induces large conformational changes that are distinct to each interacting partner. In particular, we discuss the effect of pH variation on the conformations of CaM. By using the pKa values of the charged residues as a basis to assign protonation states, the conformational changes induced in CaM by reducing the pH are studied by molecular dynamics simulations. Our current view suggests that at high pH, barrier crossing to the compact form is prevented by repulsive electrostatic interactions between the two lobes. At reduced pH, not only is barrier crossing facilitated by protonation of residues, but also conformations which are on average more compact are attained. The latter are in accordance with the fluorescence resonance energy transfer experiment results of other workers. The key events leading to the conformational change from the open to the compact conformation are (i) formation of a salt bridge between the N-lobe and the linker, stabilizing their relative motions, (ii) bending of the C-lobe towards the N-lobe, leading to a lowering of the interaction energy between the two-lobes, (iii) formation of a hydrophobic patch between the two lobes, further stabilizing the bent conformation by reducing the entropic cost of the compact form, (iv) sharing of a Ca+2 ion between the two lobes
Theoretical current-voltage characteristics of ferroelectric tunnel junctions
We present the concept of ferroelectric tunnel junctions (FTJs). These
junctions consist of two metal electrodes separated by a nanometer-thick
ferroelectric barrier. The current-voltage characteristics of FTJs are analyzed
under the assumption that the direct electron tunneling represents the dominant
conduction mechanism. First, the influence of converse piezoelectric effect
inherent in ferroelectric materials on the tunnel current is described. The
calculations show that the lattice strains of piezoelectric origin modify the
current-voltage relationship owing to strain-induced changes of the barrier
thickness, electron effective mass, and position of the conduction-band edge.
Remarkably, the conductance minimum becomes shifted from zero voltage due to
the piezoelectric effect, and a strain-related resistive switching takes place
after the polarization reversal in a ferroelectric barrier. Second, we analyze
the influence of the internal electric field arising due to imperfect screening
of polarization charges by electrons in metal electrodes. It is shown that, for
asymmetric FTJs, this depolarizing-field effect also leads to a considerable
change of the barrier resistance after the polarization reversal. However, the
symmetry of the resulting current-voltage loop is different from that
characteristic of the strain-related resistive switching. The crossover from
one to another type of the hysteretic curve, which accompanies the increase of
FTJ asymmetry, is described taking into account both the strain and
depolarizing-field effects. It is noted that asymmetric FTJs with dissimilar
top and bottom electrodes are preferable for the non-volatile memory
applications because of a larger resistance on/off ratio.Comment: 14 pages, 8 figure
Associations between Health Effects and Particulate Matter and Black Carbon in Subjects with Respiratory Disease
We measured fractional exhaled nitric oxide (FE(NO)), spirometry, blood pressure, oxygen saturation of the blood (SaO(2)), and pulse rate in 16 older subjects with asthma or chronic obstructive pulmonary disease (COPD) in Seattle, Washington. Data were collected daily for 12 days. We simultaneously collected PM(10) and PM(2.5) (particulate matter ≤10 μm or ≤2.5 μm, respectively) filter samples at a central outdoor site, as well as outside and inside the subjects’ homes. Personal PM(10) filter samples were also collected. All filters were analyzed for mass and light absorbance. We analyzed within-subject associations between health outcomes and air pollution metrics using a linear mixed-effects model with random intercept, controlling for age, ambient relative humidity, and ambient temperature. For the 7 subjects with asthma, a 10 μg/m(3) increase in 24-hr average outdoor PM(10) and PM(2.5) was associated with a 5.9 [95% confidence interval (CI), 2.9–8.9] and 4.2 ppb (95% CI, 1.3–7.1) increase in FE(NO), respectively. A 1 μg/m(3) increase in outdoor, indoor, and personal black carbon (BC) was associated with increases in FE(NO) of 2.3 ppb (95% CI, 1.1–3.6), 4.0 ppb (95% CI, 2.0–5.9), and 1.2 ppb (95% CI, 0.2–2.2), respectively. No significant association was found between PM or BC measures and changes in spirometry, blood pressure, pulse rate, or SaO(2) in these subjects. Results from this study indicate that FE(NO) may be a more sensitive marker of PM exposure than traditional health outcomes and that particle-associated BC is useful for examining associations between primary combustion constituents of PM and health outcomes
Antideuteron yield at the AGS and coalescence implications
We present Experiment 864's measurement of invariant antideuteron yields in
11.5A GeV/c Au + Pt collisions. The analysis includes 250 million triggers
representing 14 billion 10% central interactions sampled for events with high
mass candidates. We find (1/2 pi pt) d^(2)N/dydpt = 3.5 +/- 1.5 (stat.)
+0.9,-0.5 (sys.) x 10^(-8) GeV^(-2)c^(2) for 1.8=0.35 GeV/c
(y(cm)=1.6) and 3.7 +/- 2.7 (stat.) +1.4,-1.5 (sys.) x 10^(-8) GeV^(-2)c^(2)
for 1.4=0.26 GeV/c, and a coalescence parameter B2-bar of 4.1 +/-
2.9 (stat.) +2.3,-2.4 (sys.) x 10^(-3) GeV^(2)c^(-3). Implications for the
coalescence model and antimatter annihilation are discussed.Comment: 8 pages, 4 figures, Latex, submitted to Phys. Rev. Let
Atomic-scale confinement of optical fields
In the presence of matter there is no fundamental limit preventing
confinement of visible light even down to atomic scales. Achieving such
confinement and the corresponding intensity enhancement inevitably requires
simultaneous control over atomic-scale details of material structures and over
the optical modes that such structures support. By means of self-assembly we
have obtained side-by-side aligned gold nanorod dimers with robust
atomically-defined gaps reaching below 0.5 nm. The existence of
atomically-confined light fields in these gaps is demonstrated by observing
extreme Coulomb splitting of corresponding symmetric and anti-symmetric dimer
eigenmodes of more than 800 meV in white-light scattering experiments. Our
results open new perspectives for atomically-resolved spectroscopic imaging,
deeply nonlinear optics, ultra-sensing, cavity optomechanics as well as for the
realization of novel quantum-optical devices
Stratified University Strategies: The Shaping of Institutional Legitimacy in a Global Perspective
Globalizing forces have both transformed the higher education sector and made it increasingly homogenous. Growing similarities among universities have been attributed to isomorphic pressures to ensure and/or enhance legitimacy by imitating higher education institutions that are perceived as successful internationally, particularly universities that are highly ranked globally (Cantwell & Kauppinen, 2014; DiMaggio and Powell, 1983). In this study, we compared the strategic plans of 78 high-ranked, low-ranked, and unranked universities in 33 countries in 9 regions of the world. In analyzing the plans of these 78 universities, the study explored patterns of similarity and difference in universities' strategic positioning according to Suchman's (1995) 3 types of legitimacy: cognitive, pragmatic, and moral. We found evidence of stratified university strategies in a global higher education landscape that varied by institutional status. In offering a corrective to neoinstitutional theory, we suggest that patterns of globalization are mediated by status-based differences in aspirational behavior (Riesman, 1958) and "old institutional" forces (Stinchcombe, 1997) that contribute to differently situated universities pursuing new paths in seeking to build external legitimacy.18 month embargo; published online: 13 Sep 2018This item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]
The fruitfly Drosophila melanogaster contains a novel charged adipokinetic-hormone-family peptide
Antiproton Production in 11.5 A GeV/c Au+Pb Nucleus-Nucleus Collisions
We present the first results from the E864 collaboration on the production of
antiprotons in 10% central 11.5 A GeV/c Au+Pb nucleus collisions at the
Brookhaven AGS. We report invariant multiplicities for antiproton production in
the kinematic region 1.4<y<2.2 and 50<p_T<300 MeV/c, and compare our data with
a first collision scaling model and previously published results from the E878
collaboration. The differences between the E864 and E878 antiproton
measurements and the implications for antihyperon production are discussed.Comment: 4 pages, 4 figures; accepted for publication in Physical Review
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