12,279 research outputs found
Focal adhesions as mechanosensors: the two-spring model
Adhesion-dependent cells actively sense the mechanical properties of their
environment through mechanotransductory processes at focal adhesions, which are
integrin-based contacts connecting the extracellular matrix to the
cytoskeleton. Here we present first steps towards a quantitative understanding
of focal adhesions as mechanosensors. It has been shown experimentally that
high levels of force are related to growth of and signaling at focal adhesions.
In particular, activation of the small GTPase Rho through focal adhesions leads
to the formation of stress fibers. Here we discuss one way in which force might
regulate the internal state of focal adhesions, namely by modulating the
internal rupture dynamics of focal adhesions. A simple two-spring model shows
that the stiffer the environment, the more efficient cellular force is built up
at focal adhesions by molecular motors interacting with the actin filaments.Comment: Latex, 17 pages, 5 postscript figures include
Fiber optic wavelength division multiplexing: Principles and applications in telecommunications and spectroscopy
Design and fabrication tradeoffs of wavelength division multiplexers are discussed and performance parameters are given. The same multiplexer construction based on prism gratings has been used in spectroscopic applications, in the wavelength region from 450 to 1600 nm. For shorter wavelengths down to 200 nm, a similar instrument based on longer fibers (500 to 1000 micrometer) has been constructed and tested with both a fiber array and a photodiode detector array at the output
Focal adhesions as mechanosensors: the two-spring model
Adhesion-dependent cells actively sense the mechanical properties of their
environment through mechanotransductory processes at focal adhesions, which are
integrin-based contacts connecting the extracellular matrix to the
cytoskeleton. Here we present first steps towards a quantitative understanding
of focal adhesions as mechanosensors. It has been shown experimentally that
high levels of force are related to growth of and signaling at focal adhesions.
In particular, activation of the small GTPase Rho through focal adhesions leads
to the formation of stress fibers. Here we discuss one way in which force might
regulate the internal state of focal adhesions, namely by modulating the
internal rupture dynamics of focal adhesions. A simple two-spring model shows
that the stiffer the environment, the more efficient cellular force is built up
at focal adhesions by molecular motors interacting with the actin filaments.Comment: Latex, 17 pages, 5 postscript figures include
Design and Performance of the CMS Pixel Detector Readout Chip
The readout chip for the CMS pixel detector has to deal with an enormous data
rate. On-chip zero suppression is inevitable and hit data must be buffered
locally during the latency of the first level trigger. Dead-time must be kept
at a minimum. It is dominated by contributions coming from the readout. To keep
it low an analog readout scheme has been adopted where pixel addresses are
analog coded. We present the architecture of the final CMS pixel detector
readout chip with special emphasis on the analog readout chain. Measurements of
its performance are discussed.Comment: 8 pages, 11 figures. Contribution to the Proceedings of the Pixel2005
Workshop, Bonn, German
Generation of two-photon states with arbitrary degree of entanglement via nonlinear crystal superlattices
We demonstrate a general method of engineering the joint quantum state of
photon pairs produced in spontaneous parametric downconversion (PDC). The
method makes use of a superlattice structure of nonlinear and linear materials,
in conjunction with a broadband pump, to manipulate the group delays of the
signal and idler photons relative to the pump pulse, and realizes a joint
spectral amplitude with arbitrary degree of entanglement for the generated
pairs. This method of group delay engineering has the potential of synthesizing
a broad range of states including factorizable states crucial for quantum
networking and states optimized for Hong-Ou-Mandel interferometry. Experimental
results for the latter case are presented, illustrating the principles of this
approach.Comment: 4 pages, 4 figures, accepted Phys. Rev. Let
Generation of Pure-State Single-Photon Wavepackets by Conditional Preparation Based on Spontaneous Parametric Downconversion
We study the conditional preparation of single photons based on parametric
downconversion, where the detection of one photon from a given pair heralds the
existence of a single photon in the conjugate mode. We derive conditions on the
modal characteristics of the photon pairs, which ensure that the conditionally
prepared single photons are quantum-mechanically pure. We propose specific
experimental techniques that yield photon pairs ideally suited for
single-photon conditional preparation.Comment: 14 pages, 6 figure
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