360 research outputs found
The Mormon Colonies of Northern Mexico: A History, 1885-1912
This study, based almost entirely on Mormon diaries and other primary documents, suggests in the first place, that Mormonism while displaying a kind of cultural separatism on one level, was, at another level, in close harmony with American notions of economic and political expansionism. The study of the character of the colonists\u27 thought and culture, provides explanation for the difficulties imposed on Mexico Mormons during and after the 1910 Revolution. Finally, this dissertation seeks to chronicle a frontier venture. For the Mormon undertaking in northern Mexico constitutes one of the last chapters in the story of America\u27s nineteenth century pioneers
Observation of Spontaneous Brillouin Cooling
While radiation-pressure cooling is well known, the Brillouin scattering of
light from sound is considered an acousto-optical amplification-only process.
It was suggested that cooling could be possible in multi-resonance Brillouin
systems when phonons experience lower damping than light. However, this regime
was not accessible in traditional Brillouin systems since backscattering
enforces high acoustical frequencies associated with high mechanical damping.
Recently, forward Brillouin scattering in microcavities has allowed access to
low-frequency acoustical modes where mechanical dissipation is lower than
optical dissipation, in accordance with the requirements for cooling. Here we
experimentally demonstrate cooling via such a forward Brillouin process in a
microresonator. We show two regimes of operation for the Brillouin process:
acoustical amplification as is traditional, but also for the first time, a
Brillouin cooling regime. Cooling is mediated by an optical pump, and scattered
light, that beat and electrostrictively attenuate the Brownian motion of the
mechanical mode.Comment: Supplementary material include
Stability of Resonant Opto-Mechanical Oscillators
We theoretically study the frequency stability of an opto-mechanical radio
frequency oscillator based on resonant interaction of two optical and one
mechanical modes of the same optical microcavity. A generalized expression for
the phase noise of the oscillator is derived using Langevin formalism and
compared to the phase noise of existing electronic oscillators.Comment: 6 pages, 1 figur
Rotating optical soliton clusters
We introduce the concept of soliton clusters -- multi-soliton bound states in
a homogeneous bulk optical medium, and reveal a key physical mechanism for
their stabilization associated with a staircase-like phase distribution that
induces a net angular momentum and leads to cluster rotation. The ringlike
soliton clusters provide a nontrivial generalization of the concepts of
two-soliton spiraling, optical vortex solitons, and necklace-type optical
beams.Comment: 4 pages, 5 figure
Stimulated optomechanical excitation of surface acoustic waves in a microdevice
Stimulated Brillouin interaction between sound and light, known to be the
strongest optical nonlinearity common to all amorphous and crystalline
dielectrics, has been widely studied in fibers and bulk materials but rarely in
optical microresonators. The possibility of experimentally extending this
principle to excite mechanical resonances in photonic microsystems, for sensing
and frequency reference applications, has remained largely unexplored. The
challenge lies in the fact that microresonators inherently have large free
spectral range, while the phase matching considerations for the Brillouin
process require optical modes of nearby frequencies but with different
wavevectors. We rely on high-order transverse optical modes to relax this
limitation. Here we report on the experimental excitation of mechanical
resonances ranging from 49 to 1400 MHz by using forward Brillouin scattering.
These natural mechanical resonances are excited in ~100 um silica microspheres,
and are of a surface-acoustic whispering-gallery type
Cavity optomechanics on a microfluidic resonator with water and viscous liquids
Currently, optical- or mechanical-resonances are commonly used in
microfluidic research. However, optomechanical oscillations by light pressure
were not shown with liquids. This is because replacing the surrounding air with
water inherently increases the acoustical impedance and hence the associated
acoustical radiation-losses. Here, we bridge between microfluidics and
optomechanics by fabricating hollow bubble resonators with liquid inside and
optically exciting 100-MHz vibrations with only mW optical-input power. This
constitutes the first time that any microfluidic system is optomechanically
actuated. We further prove the feasibility of microfluidic optomechanics on
liquids by demonstrating vibrations on organic fluids with viscous-dissipation
higher than blood viscosity while measuring density changes in the liquid via
the vibration frequency shift. Our device will enable using cavity
optomechanics for studying non-solid phases of matter
Quantum internet using code division multiple access
A crucial open problem in large-scale quantum networks is how to efficiently
transmit quantum data among many pairs of users via a common data-transmission
medium. We propose a solution by developing a quantum code division multiple
access (q-CDMA) approach in which quantum information is chaotically encoded to
spread its spectral content, and then decoded via chaos synchronization to
separate different sender-receiver pairs. In comparison to other existing
approaches, such as frequency division multiple access (FDMA), the proposed
q-CDMA can greatly increase the information rates per channel used, especially
for very noisy quantum channels.Comment: 29 pages, 6 figure
‘1-8 interferon inducible gene family': putative colon carcinoma-associated antigens
Db−/−xβ2 microglobulin (β2m) null mice transgenic for a chimeric HLA-A2.1/Db-β2m single chain (HHD mice) are an effective biological tool to evaluate the antitumour cytotoxic T-lymphocyte response of known major histocompatibility-restricted peptide tumour-associated antigens, and to screen for putative unknown novel peptides. We utilised HHD lymphocytes to identify immunodominant epitopes of colon carcinoma overexpressed genes. We screened with HHD-derived lymphocytes over 500 HLA-A2.1-restricted peptides derived from colon carcinoma overexpressed genes. This procedure culminated in the identification of seven immunogenic peptides, three of these were derived from the ‘human 1-8D gene from interferon inducible gene' (1-8D). The 1-8D gene was shown to be overexpressed in fresh tumour samples. The three 1-8D peptides were both antigenic and immunogenic in the HHD mice. The peptides induce cytotoxic T lymphocytes that were able to kill a colon carcinoma cell line HCT/HHD, in vitro and retard its growth in vivo. One of the peptides shared by all the 1-8 gene family primed efficiently normal human cytotoxic T lymphocyte precursors. These results highlight the 1-8D gene and its homologues as putative immunodominant tumour-associated antigens of colon carcinoma
Thermal Detection Thresholds of Aδ- and C-Fibre Afferents Activated by Brief CO2 Laser Pulses Applied onto the Human Hairy Skin
Brief high-power laser pulses applied onto the hairy skin of the distal end of a limb generate a double sensation related to the activation of Aδ- and C-fibres, referred to as first and second pain. However, neurophysiological and behavioural responses related to the activation of C-fibres can be studied reliably only if the concomitant activation of Aδ-fibres is avoided. Here, using a novel CO2 laser stimulator able to deliver constant-temperature heat pulses through a feedback regulation of laser power by an online measurement of skin temperature at target site, combined with an adaptive staircase algorithm using reaction-time to distinguish between responses triggered by Aδ- and C-fibre input, we show that it is possible to estimate robustly and independently the thermal detection thresholds of Aδ-fibres (46.9±1.7°C) and C-fibres (39.8±1.7°C). Furthermore, we show that both thresholds are dependent on the skin temperature preceding and/or surrounding the test stimulus, indicating that the Aδ- and C-fibre afferents triggering the behavioural responses to brief laser pulses behave, at least partially, as detectors of a change in skin temperature rather than as pure level detectors. Most importantly, our results show that the difference in threshold between Aδ- and C-fibre afferents activated by brief laser pulses can be exploited to activate C-fibres selectively and reliably, provided that the rise in skin temperature generated by the laser stimulator is well-controlled. Our approach could constitute a tool to explore, in humans, the physiological and pathophysiological mechanisms involved in processing C- and Aδ-fibre input, respectively
LGR6 Is a High Affinity Receptor of R-Spondins and Potentially Functions as a Tumor Suppressor
BACKGROUND: LGR6 (leucine-rich repeat containing, G protein-coupled receptor 6) is a member of the rhodopsin-like seven transmembrane domain receptor superfamily with the highest homology to LGR4 and LGR5. LGR6 was found as one of the novel genes mutated in colon cancer through total exon sequencing and its promoter region is hypermethylated in 20-50% of colon cancer cases. In the skin, LGR6 marks a population of stem cells that can give rise to all cell lineages. Recently, we and others demonstrated that LGR4 and LGR5 function as receptors of R-spondins to potentiate Wnt/β-catenin signaling. However, the binding affinity and functional response of LGR6 to R-spondins, and the activity of colon cancer mutants of LGR6 have not been determined. PRINCIPAL FINDINGS: We found that LGR6 also binds and responds to R-spondins 1-3 with high affinity to enhance Wnt/β-catenin signaling through increased LRP6 phosphorylation. Similar to LGR4 and LGR5, LGR6 is not coupled to heterotrimeric G proteins or to β-arrestin following R-spondin stimulation. Functional and expression analysis of three somatic mutations identified in colon cancer samples indicates that one mutant fails to bind and respond to R-spondin (loss-of-function), but the other two have no significant effect on receptor function. Overexpression of wild-type LGR6 in HeLa cells leads to increased cell migration following co-treatment with R-spondin1 and Wnt3a when compared to vector control cells or cells overexpressing the loss-of-function mutant. CONCLUSIONS: LGR6 is a high affinity receptor for R-spondins 1-3 and potentially functions as a tumor suppressor despite its positive effect on Wnt/β-catenin signaling
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