Heat transfer mechanisms in bubbly Rayleigh-Benard convection

The heat transfer mechanism in Rayleigh-Benard convection in a liquid with a mean temperature close to its boiling point is studied through numerical simulations with point-like vapor bubbles, which are allowed to grow or shrink through evaporation and condensation and which act back on the flow both thermally and mechanically. It is shown that the effect of the bubbles is strongly dependent on the ratio of the sensible heat to the latent heat as embodied in the Jacob number Ja. For very small Ja the bubbles stabilize the flow by absorbing heat in the warmer regions and releasing it in the colder regions. With an increase in Ja, the added buoyancy due to the bubble growth destabilizes the flow with respect to single-phase convection and considerably increases the Nusselt number.Comment: 11 pages, 14 figure

The evolution of energy in flow driven by rising bubbles

We investigate by direct numerical simulations the flow that rising bubbles cause in an originally quiescent fluid. We employ the Eulerian-Lagrangian method with two-way coupling and periodic boundary conditions. In order to be able to treat up to 288000 bubbles, the following approximations and simplifications had to be introduced: (i) The bubbles were treated as point-particles, thus (ii) disregarding the near-field interactions among them, and (iii) effective force models for the lift and the drag forces were used. In particular, the lift coefficient was assumed to be 1/2, independent of the bubble Reynolds number and the local flow field. The results suggest that large scale motions are generated, owing to an inverse energy cascade from the small to the large scales. However, as the Taylor-Reynolds number is only in the range of 1, the corresponding scaling of the energy spectrum with an exponent of -5/3 cannot develop over a pronounced range. In the long term, the property of local energy transfer, characteristic of real turbulence, is lost and the input of energy equals the viscous dissipation at all scales. Due to the lack of strong vortices the bubbles spread rather uniformly in the flow. The mechanism for uniform spreading is as follows: Rising bubbles induce a velocity field behind them that acts on the following bubbles. Owing to the shear, those bubbles experience a lift force which make them spread to the left or right, thus preventing the formation of vertical bubble clusters and therefore of efficient forcing. Indeed, when the lift is artifically put to zero in the simulations, the flow is forced much more efficiently and a more pronounced energy accumulates at large scales is achieved.Comment: 9 pages, 7 figure

Dasatinib preferentially induces apoptosis by inhibiting Lyn kinase in nilotinib-resistant chronic myeloid leukemia cell line

Nilotinib is approved for treatment of newly diagnosed chronic myeloid leukemia (CML) and it is shown superiority over imatinib in first-line treatment for patients of CML. In this study, we established a nilotinib-resistant cell line, K562NR, and evaluated the resistance to nilotinib and efficacy of dasatinib. We found activation of Lyn plays a dominant role in survival of the nilotinib-resistant cell line. We found dasatinib induces the apoptosis of nilotinib-resistant cells and inhibits Lyn kinase activity. This novel nilotinib-resistant CML cell line may help to explore novel therapy for CML

Highest Energy Cosmic Rays and results from the HiRes Experiment

The status of the field of ultrahigh energy cosmic rays is summarized, from the point of view of the latest results of the High Resolution Fly's Eye (HiRes) Experiment. HiRes results are presented, and compared with those of the Akeno Giant Air Shower Array (AGASA), plus the Telescope Array and Pierre Auger experiments. The HiRes measurements of the cosmic ray spectrum, and the observation of the GZK cutoff are presented. HiRes results on composition, searches for anisotropy, measurement of the proton-air total cross section, and shapes of shower profiles are presented.Comment: 31 pages, 18 figures, submitted to Journal of Physics

Finite element simulation of three-dimensional free-surface flow problems

An adaptive finite element algorithm is described for the stable solution of three-dimensional free-surface-flow problems based primarily on the use of node movement. The algorithm also includes a discrete remeshing procedure which enhances its accuracy and robustness. The spatial discretisation allows an isoparametric piecewise-quadratic approximation of the domain geometry for accurate resolution of the curved free surface. The technique is illustrated through an implementation for surface-tension-dominated viscous flows modelled in terms of the Stokes equations with suitable boundary conditions on the deforming free surface. Two three-dimensional test problems are used to demonstrate the performance of the method: a liquid bridge problem and the formation of a fluid droplet

The Extremely High Energy Cosmic Rays

Experimental results from Haverah Park, Yakutsk, AGASA and Fly's Eye are reviewed. All these experiments work in the energy range above 0.1 EeV. The 'dip' structure around 3 EeV in the energy spectrum is well established by all the experiments, though the exact position differs slightly. Fly's Eye and Yakutsk results on the chemical composition indicate that the cosmic rays are getting lighter over the energy range from 0.1 EeV to 10 EeV, but the exact fraction is hadronic interaction model dependent, as indicated by the AGASA analysis. The arrival directions of cosmic rays are largely isotropic, but interesting features may be starting to emerge. Most of the experimental results can best be explained with the scenario that an extragalactic component gradually takes over a galactic population as energy increases and cosmic rays at the highest energies are dominated by particles coming from extragalactic space. However, identification of the extragalactic sources has not yet been successful because of limited statistics and the resolution of the data.Comment: The review paper including 21 figures. 39 pages: To be published in Journal of Physics

Kinetic modeling of H-mode pedestal with effects from anomalous transport and MHD stability

Scaling of the H-mode pedestal in tokamak plasmas with type I ELMs and dependence of the pedestal properties and the resulting divertor head load width with the plasma elongation and plasma current are investigated using the kinetic neoclassical XGC0 code for DIII-D and Alcator C-Mod tokamaks. The simulations in this study use realistic diverted geometry and are self-consistent with the inclusion of kinetic neoclassical physics, theory-based anomalous transport models with the E×B flow shearing effects, as well as an MHD ELM triggering criterion. Scalings for the pedestal width and height are developed as a function of the scanned plasma parameters. The nonlinear interplay between anomalous and neoclassical effects motivates the development of a self-consistent simulation model that includes neoclassical and anomalous effects simultaneously. It is demonstrated that the divertor heat load width depend on the plasma currents. In the development of this dependence, effects of neutral collisions and anomalous transport are taken into account. Changes in the neoclassical divertor heat load fluxes associated with the introduction of the neutral collision and anomalous transport effects are described.За допомогою кінетичного неокласичного коду XGC0 для розрядів в токамаках DIII-D і Alcator C-Mod досліджено скейлінг п’єдесталу в плазмі, що перебуває в режимі поліпшеного утримання, з прикордонними локалізованими модами (ПЛМ) першого типу, властивості п’єдесталу і потоку тепла на дивертор в залежності від витягнутості плазми та струму плазми. У розрахунках використовуються: реалістична геометрія дивертора, кінетична модель для неокласичних ефектів, модель аномального транспорту, яка враховує ефекти шира (ExB)-потоків, і умови збудження ПЛМ-нестійкостей. У результаті розрахунків отримані скейлінгі для ширини і висоти п’єдесталу як функції параметрів плазми. Нелінійна взаємодія неокласичних ефектів і ефектів, пов'язаних з аномальним транспортом, є мотивацією для розробки самоузгодженої чисельної моделі, яка одночасно включає ефекти аномального і неокласичного транспорту. Показано, що потоки тепла на дивертор залежать від плазмових струмів. Також представлено результати дослідження залежності напівширини профілів тепла на дивертор від ефектів, пов'язаних з аномальним транспортом і зіткненнями з нейтральними частинками.С помощью кинетического неоклассического кода XGC0 для разрядов в токамаках DIII-D и Alcator C-Mod исследованы скэйлинг пьедестала в плазме, находящейся в режиме улучшенного удержания, с приграничными локализованными модами (ПЛМ) первого типа, и зависимость свойств пьедестала и потока тепла на дивертор от вытянутости плазмы и тока плазмы. В расчетах используются: реалистичная геометрия дивертора, кинетическая модель для неоклассических эффектов, модель аномального транспорта, которая учитывает эффекты шира (ExB)-потоков, и условия возбуждения ПЛМ-неустойчивостей. В результате расчетов получены скэйлинги для ширины и высоты пьедестала как функции параметров плазмы. Нелинейное взаимодействие неоклассических эффектов и эффектов, связанных с аномальным транспортом, является мотивацией разработки самосогласованной численной модели, которая одновременно включает эффекты аномального и неоклассического транспорта. Показано, что потоки тепла на дивертор зависят от плазменных токов. Также представлены результаты исследования зависимости полуширины профилей тепла на дивертор от эффектов, связанных с аномальным транспортом и столкновениями с нейтральными частицами

Revising the Local Bubble Model due to Solar Wind Charge Exchange X-ray Emission

The hot Local Bubble surrounding the solar neighborhood has been primarily studied through observations of its soft X-ray emission. The measurements were obtained by attributing all of the observed local soft X-rays to the bubble. However, mounting evidence shows that the heliosphere also produces diffuse X-rays. The source is solar wind ions that have received an electron from another atom. The presence of this alternate explanation for locally produced diffuse X-rays calls into question the existence and character of the Local Bubble. This article addresses these questions. It reviews the literature on solar wind charge exchange (SWCX) X-ray production, finding that SWCX accounts for roughly half of the observed local 1/4 keV X-rays found at low latitudes. This article also makes predictions for the heliospheric O VI column density and intensity, finding them to be smaller than the observational error bars. Evidence for the continued belief that the Local Bubble contains hot gas includes the remaining local 1/4 keV intensity, the observed local O VI column density, and the need to fill the local region with some sort of plasma. If the true Local Bubble is half as bright as previously thought, then its electron density and thermal pressure are 1/square-root(2) as great as previously thought, and its energy requirements and emission measure are 1/2 as great as previously thought. These adjustments can be accommodated easily, and, in fact, bring the Local Bubble's pressure more in line with that of the adjacent material. Suggestions for future work are made.Comment: 9 pages, refereed, accepted for publication in the proceedings of the "From the Outer Heliosphere to the Local Bubble: Comparisons of New Observations with Theory" conference and in Space Science Review