Mechanical Surface Waves Accompany Action Potential Propagation

Many studies have shown that a mechanical displacement of the axonal membrane accompanies the electrical pulse defining the Action Potential (AP). Despite a large and diverse body of experimental evidence, there is no theoretical consensus either for the physical basis of this mechanical wave nor its interdependence with the electrical signal. In this manuscript we present a model for these mechanical displacements as arising from the driving of surface wave modes in which potential energy is stored in elastic properties of the neuronal membrane and cytoskeleton while kinetic energy is carried by the axoplasmic fluid. In our model these surface waves are driven by the traveling wave of electrical depolarization that characterizes the AP, altering the compressive electrostatic forces across the membrane as it passes. This driving leads to co-propagating mechanical displacements, which we term Action Waves (AWs). Our model for these AWs allows us to predict, in terms of elastic constants, axon radius and axoplasmic density and viscosity, the shape of the AW that should accompany any traveling wave of voltage, including the AP predicted by the Hodgkin and Huxley (HH) equations. We show that our model makes predictions that are in agreement with results in experimental systems including the garfish olfactory nerve and the squid giant axon. We expect our model to serve as a framework for understanding the physical origins and possible functional roles of these AWs in neurobiology.Comment: 6 pages 3 figures + 2 page supplemen

Ground states and thermal states of the random field Ising model

The random field Ising model is studied numerically at both zero and positive temperature. Ground states are mapped out in a region of random and external field strength. Thermal states and thermodynamic properties are obtained for all temperatures using the the Wang-Landau algorithm. The specific heat and susceptibility typically display sharp peaks in the critical region for large systems and strong disorder. These sharp peaks result from large domains flipping. For a given realization of disorder, ground states and thermal states near the critical line are found to be strongly correlated--a concrete manifestation of the zero temperature fixed point scenario.Comment: 5 pages, 5 figures; new material added in this versio

Evidence of non-mean-field-like low-temperature behavior in the Edwards-Anderson spin-glass model

The three-dimensional Edwards-Anderson and mean-field Sherrington-Kirkpatrick Ising spin glasses are studied via large-scale Monte Carlo simulations at low temperatures, deep within the spin-glass phase. Performing a careful statistical analysis of several thousand independent disorder realizations and using an observable that detects peaks in the overlap distribution, we show that the Sherrington-Kirkpatrick and Edwards-Anderson models have a distinctly different low-temperature behavior. The structure of the spin-glass overlap distribution for the Edwards-Anderson model suggests that its low-temperature phase has only a single pair of pure states.Comment: 4 pages, 6 figures, 2 table

Low-temperature behavior of the statistics of the overlap distribution in Ising spin-glass models

Using Monte Carlo simulations, we study in detail the overlap distribution for individual samples for several spin-glass models including the infinite-range Sherrington-Kirkpatrick model, short-range Edwards-Anderson models in three and four space dimensions, and one-dimensional long-range models with diluted power-law interactions. We study three long-range models with different powers as follows: the first is approximately equivalent to a short-range model in three dimensions, the second to a short-range model in four dimensions, and the third to a short-range model in the mean-field regime. We study an observable proposed earlier by some of us which aims to distinguish the "replica symmetry breaking" picture of the spin-glass phase from the "droplet picture," finding that larger system sizes would be needed to unambiguously determine which of these pictures describes the low-temperature state of spin glasses best, except for the Sherrington-Kirkpatrick model which is unambiguously described by replica symmetry breaking. Finally, we also study the median integrated overlap probability distribution and a typical overlap distribution, finding that these observables are not particularly helpful in distinguishing the replica symmetry breaking and the droplet pictures.Comment: 11 pages, 6 figure