Reversal of facial selectivity in the kinetic resolution of olefin via asymmetric dihydroxylation (AD) reaction: Synthesis of optically active (–)-miiltlactone and (+)-isomintlactone by AD reaction from intrinsically disfavoured diastereoface of alkene

226-23

Stereos elective transformations of polyhydroxyazepanes to piperidine and pyrrolidine derivatives-Efficient glycosidase inhibitors

220-22

Intramolecular SN2 ring opening of cyclic sulfates: 6-exo-Tet versus 7-endo-Tet cyclization

209-21

Diphenylphosphinoyl chloride as a chlorinating agent - The selective double activation of 1,2-diols

© The Royal Society of Chemistry 2006Treatment of 1,2-diols with diphenylphosphinoyl chloride in pyridine produces beta-chloroethyl phosphinates which react with complete control of stereochemistry to give epoxides and azido-alcohols, useful intermediates in cyclopropane synthesis.David J. Fox, Daniel Sejer Pedersen, Asger B. Petersen and Stuart Warre

tert-Butyl 2-hy­droxy-3-(4-methyl­benzene­sulfonamido)­butano­ate

In the crystal of the title compound, C15H23NO5S, mol­ecules are linked through N—H⋯O and O—H⋯O hydrogen-bond inter­actions, resulting in centrosymmetric dimers in which the N—H⋯O inter­actions generate R 2 2(12) rings and the O—H⋯O inter­actions generate R 2 2(14) rings. Weak inter­molecular C—H⋯O inter­actions are also observed

(2R,3S)-Methyl 2-hy­droxy-3-(4-methyl­benzene­sulfonamido)-3-phenyl­propano­ate

In the title mol­ecule, C17H19NO5S, the p-tolyl ring is oriented approximately parallel to the phenyl ring [dihedral angle = 17.2 (1)°], resulting in an intra­molecular π–π inter­ation [centroid–centroid distance = 3.184 (10) Å]. In the crystal, mol­ecules are linked through O—H⋯O and C—H⋯O hydrogen bonds, forming hydrogen-bonded sheets lying diagonally across the ac face

Oxazolidine-2-thiones: A molecular modeling study

Two oxazolidine-2-thiones, thio-analogs of linezolid, were synthesized and their antibacterial properties evaluated. Unlike oxazolidinones, the thio-analogs did not inhibit the growth of Gram positive bacteria. A molecular modeling study has been carried out to aid understanding of this unexpected finding