Second-order nonlinear optical properties induced by thermal poling in photonic oxide glasses and transparent glass-ceramics

In recent years there has been a resurgence of interest in oxide glasses due to advances in lasers for information transport. Oxide glasses combine low cost of fabrication and good compatibility with silica glass fibers, which offer the opportunity for developing structures with nonlinear optical properties in integrated optical devices. The creation of an axial symmetry under thermal poling is currently necessary to induce Second-Order NonLinear (SONL) optical properties in glasses. A description of theoretical models which have been proposed for charge migration during thermal poling is presented. A review of SONL efficiencies which have been obtained for different glass compositions by this method is reported. Correlations between SONL properties and structural modifications under poling are also presented. Finally, we focus on the challenging fabrication of transparent glass-ceramic composites, especially when they are obtained by the precipitation of ferroelectric nanoparticle phases in the glassy matrix which adds the advantageous SONL properties of ferroelectric crystals

Couplings of N=1 chiral spinor multiplets

We derive the action for chiral spinor multiplets coupled to vector and scalar multiplets. We give the component form of the action, which contains gauge invariant mass terms for the antisymmetric tensors in the spinor superfield and additional Green-Schwarz couplings to vector fields. We observe that supersymmetry provides mass terms for the scalars in the spinor multiplet which do not arise from eliminating an auxiliary field. We construct the dual action by explicitly performing the duality transformations in superspace and give its component form.Comment: 17 pages, v2 small change

Calabi-Yau Fourfolds with Flux and Supersymmetry Breaking

In Calabi-Yau fourfold compactifications of M-theory with flux, we investigate the possibility of partial supersymmetry breaking in the three-dimensional effective theory. To this end, we place the effective theory in the framework of general N=2 gauged supergravities, in the special case where only translational symmetries are gauged. This allows us to extract supersymmetry-breaking conditions, and interpret them as conditions on the 4-form flux and Calabi-Yau geometry. For N=2 unbroken supersymmetry in three dimensions we recover previously known results, and we find a new condition for breaking supersymmetry from N=2 to N=1, i.e. from four to two supercharges. An example of a Calabi-Yau hypersurface in a toric variety that satisfies this condition is provided.Comment: 26 page

Gaugino Condensation with S-Duality and Field-Theoretical Threshold Corrections

We study gaugino condensation in the presence of an intermediate mass scale in the hidden sector. S-duality is imposed as an approximate symmetry of the effective supergravity theory. Furthermore, we include in the K\"ahler potential the renormalization of the gauge coupling and the one-loop threshold corrections at the intermediate scale. It is shown that confinement is indeed achieved. Furthermore, a new running behaviour of the dilaton arises which we attribute to S-duality. We also discuss the effects of the intermediate scale, and possible phenomenological implications of this model.Comment: 19 pages, LaTeX, 3 postscript figures include

Gaugino Condensation in N=1 Supergravity Models with Multiple Dilaton-Like Fields

We study supersymmetry breaking by hidden-sector gaugino condensation in N=1 D=4 supergravity models with multiple dilaton-like moduli fields. Our work is motivated by Type I string theory, in which the low-energy effective Lagrangian can have different dilaton-like fields coupling to different sectors of the theory. We construct the effective Lagrangian for gaugino condensation and use it to compute the visible-sector gaugino masses. We find that the gaugino masses can be of order the gravitino mass, in stark contrast to heterotic string models with a single dilaton field.Comment: LaTeX, 17 pages, 2 eps figure

Phase I dose escalation study of telatinib (BAY 57-9352) in patients with advanced solid tumours

Telatinib (BAY 57-9352) is an orally available, small-molecule inhibitor of vascular endothelial growth factor receptors 2 and 3 (VEGFR-2/-3) and platelet-derived growth factor receptor β tyrosine kinases. In this multicentre phase I dose escalation study, 71 patients with refractory solid tumours were enroled into 14 days on/7 days off (noncontinuous dosing) or continuous dosing groups to receive telatinib two times daily (BID). Hypertension (23%) and diarrhoea (7%) were the most frequent study drug-related adverse events of CTC grade 3. The maximum-tolerated dose was not reached up to a dose of 1500 mg BID continuous dosing. Telatinib was rapidly absorbed with median tmax of 3 hours or less. Geometric mean Cmax and AUC0−12 increased in a less than dose-proportional manner and plateaued in the 900–1500 mg BID dose range. Two renal cell carcinoma patients reached a partial response. Tumour blood flow measured by contrast-enhanced magnetic resonance imaging and sVEGFR-2 plasma levels decreased with increasing AUC0−12 of telatinib. Telatinib is safe and well tolerated up to a dose of 1500 mg BID continuous dosing. Based on pharmacokinetic and pharmacodynamic criteria, 900 mg telatinib BID continuously administered was selected as the recommended phase II dose

Potential biological role of poly (ADP-ribose) polymerase (PARP) in male gametes

Maintaining the integrity of sperm DNA is vital to reproduction and male fertility. Sperm contain a number of molecules and pathways for the repair of base excision, base mismatches and DNA strand breaks. The presence of Poly (ADP-ribose) polymerase (PARP), a DNA repair enzyme, and its homologues has recently been shown in male germ cells, specifically during stage VII of spermatogenesis. High PARP expression has been reported in mature spermatozoa and in proven fertile men. Whenever there are strand breaks in sperm DNA due to oxidative stress, chromatin remodeling or cell death, PARP is activated. However, the cleavage of PARP by caspase-3 inactivates it and inhibits PARP's DNA-repairing abilities. Therefore, cleaved PARP (cPARP) may be considered a marker of apoptosis. The presence of higher levels of cPARP in sperm of infertile men adds a new proof for the correlation between apoptosis and male infertility. This review describes the possible biological significance of PARP in mammalian cells with the focus on male reproduction. The review elaborates on the role played by PARP during spermatogenesis, sperm maturation in ejaculated spermatozoa and the potential role of PARP as new marker of sperm damage. PARP could provide new strategies to preserve fertility in cancer patients subjected to genotoxic stresses and may be a key to better male reproductive health