Representations of (2,n)(2,n)-semigroups by multiplace functions

We describe the representations of $(2,n)$-semigroups, i.e. groupoids with $n$ binary associative operations, by partial $n$-place functions and prove that any such representation is a union of some family of representations induced by Schein's determining pairs.Comment: 17 page

Hsp27 anti-sense oligonucleotides sensitize the microtubular cytoskeleton of Chinese hamster ovary cells grown at low pH to 42 degrees C-induced reorganization

Chinese hamster ovary (CHO) cells maintained in vitro at pH 6.7 were used to model cells in the acidic environment of tumours. CHO cells grown at pH 6.7 develop thermotolerance during 42 degrees C heating at pH 6.7 and their cytoskeletal systems are resistant to 42 degrees C-induced perinuclear collapse. Hsp27 levels are elevated in cells grown at pH 6.7 and are further induced during 42 degrees C heating, while Hsp70 levels remain low or undetectable, suggesting that Hsp27 is responsible for some of the novel characteristics of these cells. An anti-sense oligonucleotide strategy was used to test the importance of Hsp27 by lowering heat-induced levels of the protein. The response of the microtubular cytoskeleton to heat was used as an endpoint to assess the effectiveness of the anti-sense strategy. Treatment with anti-sense oligonucleotides prevented the heat-induced increase of Hsp27 levels measured immediately following heat. Treatment with anti-sense oligonucleotides also sensitized the cytoskeleton of cells grown at low pH to heat-induced perinuclear collapse. However, cytoskeletal collapse was not evident in cells grown at pH 6.7 and treated with 4-nt mismatch oligonucleotides or in control cells maintained and heated at pH 6.7. The cytoskeleton collapsed around the nucleus in cells cultured and heated at pH 7.3. These results confirm that over-expression of Hsp27 confers heat protection to the microtubular cytoskeleton in CHO cells grown at low pH

Representations of Menger (2,n)(2,n)-semigroups by multiplace functions

Investigation of partial multiplace functions by algebraic methods plays an important role in modern mathematics were we consider various operations on sets of functions, which are naturally defined. The basic operation for $n$-place functions is an $(n+1)$-ary superposition $[ ]$, but there are some other naturally defined operations, which are also worth of consideration. In this paper we consider binary Mann's compositions \op{1},...,\op{n} for partial $n$-place functions, which have many important applications for the study of binary and $n$-ary operations. We present methods of representations of such algebras by $n$-place functions and find an abstract characterization of the set of $n$-place functions closed with respect to the set-theoretic inclusion

Radiotomographic system construction on the basis of multi-elemental reflective array

The authors propose a solution of the problem of radiovision using the reflective array, each element of which can change the reflection coefficient under the action of external control voltage. The focusing abilities of flat reflection array of monochromatic radiation were studied to solve the problem of radiovision. The array element based on waveguide with a controlled reflection coefficient was developed. The phase shift switching is 180°

Concentration of salivary protective proteins within the bound oral mucosal pellicle

Objectives: To study which salivary proteins form the protective bound mucosal pellicle and to determine the role of transglutaminase in pellicle development. Materials and Methods: Oral epithelial cells were collected and underwent washes of different strengths, followed by homogenisation. SDS-PAGE, western blotting, IgA ELISAs and amylase activity assays were completed on cell homogenates and compared to saliva samples to confirm which salivary proteins were bound to cell surfaces. Results: Salivary mucins, MUC5B and MUC7, were strongly retained on the oral epithelial cell surface. Other bound proteins including cystatin S, carbonic anhydrase VI, secretory component and IgA could be washed off. IgA was present in concentrated levels in the bound mucosal pellicle compared to amounts in saliva. Amylase, one of the most abundant proteins present in saliva, showed minimal levels of binding. Transglutaminase 3 presence was confirmed, but proteins that it catalyses cross-links between, statherin and proline-rich proteins, showed minimal presence. Conclusion: Some protective salivary proteins including mucins and IgA become concentrated on oral surfaces in the bound mucosal pellicle, through specific interactions. Concentration of mucins would contribute to lubrication to prevent abrasion damage to soft tissues, whilst increased IgA could create an 'immune reservoir' against mucosal infection.</p

Complex sequrity system for premises under conditions of large volume of passenger traffic

Subsystems of the design of a complex security system for premises under conditions of large volume of passenger traffic are considered. These subsystems provide video- and thermal imaging control, radio wave tomography, and gas analysis. Simultaneous application of all examined variants will essentially increase the probability of timely prevention of dangerous situations with the probability of false alarm as low as possible. It is important that finally, this will provide protection of population and will facilitate the work of intelligence services

Fresnel flat reflector with focusing capability

Theoretical modeling of a Fresnel flat reflector for focusing radiation in the point near the reflector is discussed in this paper. It shows that the reflector calculated for one frequency and one focus position can also be used for other frequencies, but a focusing point should be shifted along a focusing line. Fresnel reflector can be used for a space-frequency filtration in a wide frequency range

Преобразование кардиологических палат интенсивной терапии в кардиологическую реанимацию. Пятилетняя эволюция

The article highlights the key elements and results of the restructuring of emergency care for patients with acute myocardial infarction, the core of which is the teamwork of surgeons, anesthesiologist-intensivists and cardiologists of the department. The restructuring included a change in ideology, personnel changes, updating and expanding the range of equipment, development of inner protocols and their implementation. It took two years to transform the intensive care unit for patients with acute myocardial infarction into the cardiac intensive care unit, where patients with acute cardiac pathologies of various etiologies are treated and preoperative preparation and postoperative nursing are carried out.В статье освещаются ключевые элементы и результаты реструктуризации неотложной помощи пациентам с острым инфрактом миокарда, ядром которой является командная работа хирургов, анестезиологов-реаниматологов и кардиологов в отделении. Реструктуризация включала в себя изменение идеологии, кадровые перестановки, обновление и увеличение номенклатуры оборудования. Трансформация отделения интенсивной терапии для пациентов с острым инфарктом миокарда в отделение кардиореанимации, где проходят лечение пациенты с острой кардиальной патологией разной этиологии и проводится предоперационная подготовка и послеоперационное выхаживание, заняла два года

Self-association of the glycopeptide antibiotic teicoplanin A2 in aqueous solution studied by molecular hydrodynamics

AbstractThe natural glycopeptide antibiotic teicoplanin is used for the treatment of serious Gram-positive related bacterial infections and can be administered intravenously, intramuscularly, topically (ocular infections), or orally. It has also been considered for targeting viral infection by SARS-CoV-2. The hydrodynamic properties of teicoplanin A2 (M1 = 1880 g/mol) were examined in phosphate chloride buffer (pH 6.8, I = 0.10 M) using sedimentation velocity and sedimentation equilibrium in the analytical ultracentrifuge together with capillary (rolling ball) viscometry. In the concentration range, 0–10 mg/mL teicoplanin A2 was found to self-associate plateauing &gt; 1 mg/mL to give a molar mass of (35,400 ± 1000) g/mol corresponding to ~ (19 ± 1) mers, with a sedimentation coefficient s20, w =  ~ 4.65 S. The intrinsic viscosity [$$\eta$$ η ] was found to be (3.2 ± 0.1) mL/g: both this, the value for s20,w and the hydrodynamic radius from dynamic light scattering are consistent with a globular macromolecular assembly, with a swelling ratio through dynamic hydration processes of ~ 2. </jats:p