Metabolites content of stable forms of nitric oxide in the lungs of guinea pigs with experimental allergic alveolitis in different periods of its formation

Reheda M. S., Melekh B. Ya., Kachmarska M. O. Metabolites content of stable forms of nitric oxide in the lungs of guinea pigs with experimental allergic alveolitis in different periods of its formation. Journal of Education, Health and Sport. 2017;7(4):707-714. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.573919 http://ojs.ukw.edu.pl/index.php/johs/article/view/4453 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 12.04.2017. Revised: 10.04.2017. Accepted: 25.04.2017. METABOLITES CONTENT of stable forms of nitric oxide in the lungs of guinea pigs with experimental allergic alveolitis in different periods of its formation M. S. Reheda, B. Ya. Melekh, M. O. Kachmarska Lviv National Medical University named after Danylo Galitskyy Abstract In this paper was found that the conditions for the development of experimental allergic alveolitis on the 44-th day increased the activity of inducible nitric oxide synthase and stable forms of nitric oxide metabolites. These changes were probably related to proinflammatory properties of nitric oxide and the development of adequate immune response. Significant increase of nitric oxide metabolites can be used as a diagnostic method of development of allergic alveolitis by determining the concentration of these metabolites in exhaled air. Key words: nitric oxide, L-arginine, NO-synthase, experimental allergic alveolitis