69 research outputs found
Study of the asymmetric organocatalyzed [3+2] annulation of cyclopropenone and β-keto ester
No full textEnantioselective, Organocatalytic Reduction of Ketones using Bifunctional Thiourea-Amine Catalysts
No full textAlkaloid-Derived Thioureas in Asymmetric Organocatalysis: A Cooperative Learning Activity in a Project-Based Laboratory Course
No full textDevelopment of an Asymmetric Trimethylenemethane Cycloaddition Reaction: Application in the Enantioselective Synthesis of Highly Substituted Carbocycles
No full textEnantioselective Synthesis of β-(3-Hydroxypyrazol-1-yl) Ketones Using an Organocatalyzed Michael Addition Reaction
No full textEnantioselective organocatalytic conjugate addition of nitroalkanes to electrophilic 2-iminochromenes
No full text10.1021/cs300313jACS Catalysis281535-153
Vinylogous Reactivity of Oxindoles Bearing Nonsymmetric 3‑Alkylidene Groups
No full textThe
γ-functionalization of oxindoles bearing nonsymmetric 3-alkylidene
groups via vinylogous Michael-type addition to nitroolefins
was realized. The suppression of the interconversion between the <i>E</i> and <i>Z</i> isomers of the starting oxindoles
allowed a site-specific diastereoselective and enantioselective transformation.
Specific experiments allowed us to establish the rate-determining
step of the reaction and to advance a robust hypothesis for the
exclusive formation of an <i>s-cis</i> enolate as the only
reactive intermediate
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