Desenvolvimento de Cryptolaemus montrouzieri (Coleoptera: Coccinellidae) alimentado com ovos de Ceratitis capitata (Diptera: Tephritidae).

O objetivo deste trabalho foi avaliar o desenvolvimento de C. montrouzieri criado em uma dieta composta apenas por ovos de C. capitata para possibilitar um método de criação desta joaninha com baixo custo, de modo a obter este inimigo natural em quantidades suficientes para utilização em programas de manejo integrado de pragas

Correlation length scalings in fusion edge plasma turbulence computations

The effect of changes in plasma parameters, that are characteristic near or at an L-H transition in fusion edge plasmas, on fluctuation correlation lengths are analysed by means of drift-Alfven turbulence computations. Scalings by density gradient length, collisionality, plasma beta, and by an imposed shear flow are considered. It is found that strongly sheared flows lead to the appearence of long-range correlations in electrostatic potential fluctuations parallel and perpendicular to the magnetic field.Comment: Submitted to "Plasma Physics and Controlled Fusion

Desenvolvimento de escala diagramática de severidade para a ferrugem do pinhão-manso.

Objetivou-se com este trabalho, desenvolver escala diagramática de severidade para quantificação de danos provocados por Phakopsora arthuriana em folhas de pinhão-manso.bitstream/item/76155/1/cot368-escaladiagramaticapinhapmanso.pd

Antiplasmodial activity of chloroquine analogs against chloroquine-resistant parasites, docking studies and mechanisms of drug action

Submitted by Nuzia Santos ([email protected]) on 2015-03-02T17:19:49Z No. of bitstreams: 1 2014_121.pdf: 1273925 bytes, checksum: 09c618c236f85c7e45f2ad6a53efc484 (MD5)Approved for entry into archive by Nuzia Santos ([email protected]) on 2015-03-02T17:19:57Z (GMT) No. of bitstreams: 1 2014_121.pdf: 1273925 bytes, checksum: 09c618c236f85c7e45f2ad6a53efc484 (MD5)Approved for entry into archive by Nuzia Santos ([email protected]) on 2015-03-02T17:23:45Z (GMT) No. of bitstreams: 1 2014_121.pdf: 1273925 bytes, checksum: 09c618c236f85c7e45f2ad6a53efc484 (MD5)Made available in DSpace on 2015-03-02T17:23:45Z (GMT). No. of bitstreams: 1 2014_121.pdf: 1273925 bytes, checksum: 09c618c236f85c7e45f2ad6a53efc484 (MD5) Previous issue date: 2014Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, BrazilUniversidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, BrazilUniversidade Federal de Juiz de Fora. Instituto de Ciências Exatas. Departamento de Química. Juiz de Fora, MG, BrazilInstituto Militar de Engenharia. Laboratório de Modelagem Molecular Aplicada à Defesa Química e Biológica. Rio de Janeiro, RJ, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Laboratório de Malária. Belo Horizonte, MG, BrazilBackground: Given the threat of resistance of human malaria parasites, including to artemisinin derivatives, new agents are needed. Chloroquine (CQ) has been the most widely used anti-malarial, and new analogs (CQAns) presenting alkynes and side chain variations with high antiplasmodial activity were evaluated. Methods: Six diaminealkyne and diaminedialkyne CQAns were evaluated against CQ-resistant (CQ-R) (W2) and CQ-sensitive (CQ-S) (3D7) Plasmodium falciparum parasites in culture. Drug cytotoxicity to a human hepatoma cell line (HepG2) evaluated, allowed to calculate the drug selectivity index (SI), a ratio of drug toxicity to activity in vitro. The CQAns were re-evaluated against CQ-resistant and -sensitive P. berghei parasites in mice using the suppressive test. Docking studies with the CQAns and the human (HssLDH) or plasmodial lactate dehydrogenase (PfLDH) enzymes, and, a β-haematin formation assay were performed using a lipid as a catalyst to promote crystallization in vitro. Results: All tested CQAns were highly active against CQ-R P. falciparum parasites, exhibiting half-maximal inhibitory concentration (IC50) values below 1 μΜ. CQAn33 and CQAn37 had the highest SIs. Docking studies revealed the best conformation of CQAn33 inside the binding pocket of PfLDH; specificity between the residues involved in H-bonds of the PfLDH with CQAn37. CQAn33 and CQAn37 were also shown to be weak inhibitors of PfLDH. CQAn33 and CQAn37 inhibited β-haematin formation with either a similar or a 2-fold higher IC50 value, respectively, compared with CQ. CQAn37 was active in mice with P. berghei, reducing parasitaemia by 100%. CQAn33, -39 and -45 also inhibited CQ-resistant P. berghei parasites in mice, whereas high doses of CQ were inactive. Conclusions: The presence of an alkyne group and the size of the side chain affected anti-P. falciparum activityin vitro. Docking studies suggested a mechanism of action other than PfLDH inhibition. The β-haematin assay suggested the presence of an additional mechanism of action of CQAn33 and CQAn37. Tests with CQAn34, CQAn37, CQAn39 and CQAn45 confirmed previous results against P. berghei malaria in mice, and CQAn33, 39 and 45 were active against CQ-resistant parasites, but CQAn28 and CQAn34 were not. The result likely reflects structure-activity relationships related to the resistant phenotype

Ocorrência de ácaros em cultivares comerciais de soja na safra 2009/2010.

bitstream/item/79645/1/Comunicado-289.pd

Horava-Lifshitz modifications of the Casimir effect

We study the modifications induced by spacetime anisotropy on the Casimir effect in the case of two parallel plates. Nonperturbative and perturbative regimes are analyzed. In the first case the Casimir force either vanishes or it reverses its direction which, in any case, makes the proposal untenable. On the other hand, the perturbative model enables us to incorporate appropriately the effects of spacetime anisotropy.Comment: 6 pages, revtex

Avaliação e conservação do cavalo pantaneiro.

Os cavalos introduzidos no Pantanal pelos conquistadores durante a epoca da colonizacao, encontraram na regiao condicoes ambientais propicias para sua multiplicacao. Como consequencia dos processos adaptativos e da selecao natural por mais de dois seculos e com pouca ou nenhuma interferencia antropica, surgiu um tipo adaptado ao meio. Com o desenvolvimento da pecuaria na regiao, o cavalo Pantaneiro constituiu-se num fator de importancia economica e social, tornando-se imprescindivel em trabalhos de gado e no transporte regional. No final do seculo XIX, a raca entrou em declinio principalmente devido a doenca conhecida como Peste das cadeiras e, posteriormente, outras ameacas como cruzamentos indiscriminados com outras racas e, mais recentemente a Anemia Infecciosa Equina (AIE). Em 1972, trabalhos de conservacao deste ecotipo tiveram inicio com a criacao da Associacao Brasileira dos Criadores de Cavalo Pantaneiro (ABCCP) e, posteriormente com a iniciativa de outras instituicoes governamentais. Visando conservar e incentivar a criacao do cavalo Pantaneiro, a EMBRAPA/CPAP implantou em 1988, um nucleo de criacao de cavalos Pantaneiro na fazenda Nhumirim, sub-regiao da Nhecolandia, Corumba, MS. Neste nucleo sao realizados estudos relacionados aos aspectos nutricionais, reprodutivos, geneticos, sanitarios e de performance. Paralelamente, o CPAP vem realizando trabalhos de caracterizacao do sistema de criacao no Pantanal, estudos sobre a origem e caracterizacao genetica da raca. Em conjunto com a ABCCP estao sendo analisadas as informacoes contidas nas fichas de registros genealogicos para estudo dos aspectos morfologicos.bitstream/item/37578/1/CT21.pd