The Shaker Potassium Channel Is No Target for Xenon Anesthesia in Short-Sleeping Drosophila melanogaster Mutants

Background. Xenon seems to be an ideal anesthetic drug. To explore if next to the antagonism at the NMDA-receptor other molecular targets are involved, we tested the xenon requirement in short sleeping Drosophila shaker mutants and in na[har38]. Methods. The Drosophila melanogaster strains wildtype Canton-S, na[har38], sh102 and shmns, were raised and sleep was measured. Based on the response of the flies at different xenon concentrations, logEC50 values were calculated. Results. The logEC50-values for WT Canton-S were 1.671 (1.601–1.742 95%-confidence intervall; n = 238; P versus sh102 > 0,05), for shmns 1.711 (1.650–1.773; n = 242; P versus WT Canton-S > 0,05). The logEC50-value for sh102 was 1.594 (1.493–1.694; n = 261; P versus shmns > 0.05). The logEC-value of na[har38] was 2.076 (1.619–2.532; n = 207; P versus shmns < 0.05, versus sh102 < 0.05, versus WT Canton-S < 0.05). P values for all shaker mutants were P > 0.05, while na[har38] was found to be hyposensitive compared to wildtype (P < 0.05). Conclusions. The xenon requirement in Drosophila melanogaster is not influenced by a single gene mutation at the shaker locus, whereas a reduced expression of a nonselective cation channel leads to an increased xenon requirement. This supports the thesis that xenon mediates its effects not only via an antagonism at the NMDA-receptor

An empirically observed pitch-angle diffusion eigenmode in the Earth\u27s electron belt near L* = 5.0

Abstract Using data from NASA\u27s Van Allen Probes, we have identified a synchronized exponential decay of electron flux in the outer zone, near L* = 5.0. Exponential decays strongly indicate the presence of a pure eigenmode of a diffusion operator acting in the synchronized dimension(s). The decay has a time scale of about 4 days with no dependence on pitch angle. While flux at nearby energies and L* is also decaying exponentially, the decay time varies in those dimensions. This suggests the primary decay mechanism is elastic pitch angle scattering, which itself depends on energy and L *. We invert the shape of the observed eigenmode to obtain an approximate shape of the pitch angle diffusion coefficient and show excellent agreement with diffusion by plasmaspheric hiss. Our results suggest that empirically derived eigenmodes provide a powerful diagnostic of the dynamic processes behind exponential decays

Structure of 10N in 9C+p resonance scattering

The structure of exotic nucleus 10N was studied using 9C+p resonance scattering. Two L=0 resonances were found to be the lowest states in 10N. The ground state of 10N is unbound with respect to proton decay by 2.2(2) or 1.9(2) MeV depending on the 2- or 1- spin-parity assignment, and the first excited state is unbound by 2.8(2) MeV.Comment: 6 pages, 4 figures, 1 table, submitted to Phys. Lett.

Nuclear structure beyond the neutron drip line: the lowest energy states in 9^9He via their T=5/2 isobaric analogs in 9^9Li

The level structure of the very neutron rich and unbound $^9$He nucleus has been the subject of significant experimental and theoretical study. Many recent works have claimed that the two lowest energy $^9$He states exist with spins $J^\pi=1/2^+$ and $J^\pi=1/2^-$ and widths on the order of hundreds of keV. These findings cannot be reconciled with our contemporary understanding of nuclear structure. The present work is the first high-resolution study with low statistical uncertainty of the relevant excitation energy range in the $^8$He$+n$ system, performed via a search for the T=5/2 isobaric analog states in $^9$Li populated through $^8$He+p elastic scattering. The present data show no indication of any narrow structures. Instead, we find evidence for a broad $J^{\pi}=1/2^+$ state in $^9$He located approximately 3 MeV above the neutron decay threshold

Evolution of the E(1/21+)−E(3/21+)E(1/2^+_1)-E(3/2^+_1) energy spacing in odd-mass K, Cl and P isotopes for N=20−28N=20-28

The energy of the first excited state in the neutron-rich N=28 nucleus 45Cl has been established via in-beam gamma-ray spectroscopy following proton removal. This energy value completes the systematics of the E(1/2^+_1)-E(3/2^+_1) level spacing in odd-mass K, Cl and P isotopes for N=20-28. The results are discussed in the framework of shell-model calculations in the sd-fp model space. The contribution of the central, spin-orbit and tensor components is discussed from a calculation based on a proton single-hole spectrum from G-matrix and pi + rho meson exchange potentials. A composite model for the proton 0d_{3/2}-1s_{1/2} single-particle energy shift is presented.Comment: Phys. Rev. C, in pres