Montmorillonite K 10 clay catalyzed Friedlander synthesis of 1,8-naphthyridines in dry media under microwave irradiation

2749-2750Montmorillonite K 10 clay catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing -methylene group 2 has been achieved in solvent-free condition under microwave irradiation to give 1,8-naphthyridine derivatives 3</b

Microwave assisted synthesis of N-(3-aryl-1,8-naphthyridin-2-yl) phthalimides under solvent-free conditions

207-209A simple, rapid and efficient protocol for the synthesis of N-(3-aryl-1,8-naphthyridin-2-yl)phthalimides 3 has been achieved by the reaction of 2-amino-3-aryl-1,8-naphthyridines 1 with phthalic anhydride 2 in the presence of catalytic amount of DMF under microwave irradiation

Synthesis and antimicrobial screening of certain novel Mannich bases bearing 1,8- naphthyridine moiety

2724-2726Treatment of (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetic acid hydrazide 1 with different isatins 2 affords (2-oxo-3-phenyl-2H-[1,8]naphthyridin-l -yl)-acetic acid (2-oxo-1,2-dihydroindol-3-ylidene)hydrazides 3. Aminomethylation of 3 with formaldehyde and cyclic secondary amines furnishes (2-oxo-3- phenyl-2H-[1,8]naphthyridin-l-yl)acetic acid (l-aminomethyl-2-oxo-1 ,2-dihydroindol-3-ylidene)hydrazides 4 (Mannich bases). The structural assignments to these compounds are based on their elemental analyses and spectral data. The antibacterial activity of Mannich bases 4 have been studied

Microwave induced eco-friendly solvent-free synthesis of 6-arylquinazolino[3,2-α] [1,8]naphthyridin-13-ones

1584-1586An efficient and rapid method for the synthesis of 6-arylquinazolino[3<span style="color:#121212;mso-bidi-language: HI">,2-α] [1,8]naphthyridin-13-ones 3 by the reaction of 3-aryl-2-chloro-1,8-naphthyridines 1 with anthranilic acid 2 in the presence of catalytic amount of DMF in solvent-free conditions under microwave irradiation is reported. The products are obtained in very good yields and in a state of high purity<span style="color:#3A3A3A; mso-bidi-language:HI">. </span

Hydrochemical appraisal of groundwater quality for drinking and agricultural utility in a granitic terrain of Maheshwaram area of Ranga Reddy district, Telnagana State, India

Groundwater is the major source of water both for drinking and agriculture activities in India. Water availability and quality depends on the rock formations present in the region. To study the quality of water forty-two samples have been collected during periods (May-2015) and (December-2015). Groundwater samples are reported to be having chemical constituents above the BIS and WHO standards for drinking purposes. TDS, TH, Chloride and Nitrates are above the standard specifications with reference to drinking water and one-third of the region is unsuitable for domestic purposes. Based on the Irrigation water quality indices reveal that majority of the samples are acceptable for irrigation water except few samples are unacceptable limit for irrigation purposes. Data plotted in the Piper trilinear showed that dominant water types are Ca2+-Mg2+-Cl− and Ca2-Na+-HCO3− mixed. Cluster analysis indicates that the hydrogeochemical processes involved are due to weathering of rocks, reverse ion exchange, and anthropogenic inputs it

Novel synthesis of substituted <i>N</i>-(3-aryl-1,8-naphthyridin-2-yl) and <i>N,N</i>′-bis(3-aryl-1,8-naphthyridin-2-yl)benzene-1,4-diamines and 2-(4-((3-aryl-1,8-naphthyridin-2-yl)amino)phenyl)isoindoline-1,3-diones and their biological evaluation

<p>A straightforward and highly efficient series of new substituted 3-aryl-1,8-naphthyridine derivatives <b>3a–e, 4a–e</b>, and <b>6a–e</b> were synthesized. Condensation dissimilar quantities of 2-chloro-3-aryl-1,8-naphthyridine <b>1a–e</b> with benzene-1,4-diamine <b>2</b> and sodium ethoxide refluxing in ethanol solvent yielded the compounds <b>3a–e</b> and <b>4a–e</b>. The 2-(4-((3-aryl-1,8-naphthyridin-2-yl)amino)phenyl)isoindoline-1,3-diones <b>6a–e</b> were obtained by treatment of compounds <b>3a–e</b> with phthalic anhydride <b>5</b> in refluxing <i>N,N</i>-dimethylformamide is described. All synthesized compounds evaluated for their antimicrobial activity. The structures of the compounds have been proven on the established of spectral (IR, ¹H NMR, and ¹³C NMR) data and elemental analyses. The reaction will be characterized by good efficacy, easy workup, simple purification of the products, and availability of catalyst.</p