5 research outputs found
Development of Data Processing Skills of Physics Students in Intermediate Laboratory Course
Peer reviewe
ΠΠ½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ ΡΡΠΎΠΏΠ°ΡΠΎΠ³Π΅Π½ΠΎΠ² Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΡΡΠΎΠ»ΠΈΡΠΈΠ°Π·ΠΎΠΌ Π½Π° ΡΠΎΠ½Π΅ ΡΠΎΠΏΡΡΡΡΠ²ΡΡΡΠ΅ΠΉ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ ΡΠ΅ΡΠ΄ΡΠ°
Objective: to identify the main causative agents of chronic calculous pyelonephritis and determine their antibiotic resistance in patients with nephrolithiasis combined with coronary heart disease (CHD).Material and methods. A retrospective case-control study included 181 patients aged 57 to 82 years old who were treated at the urological center of branch no. 1 of Burdenko Main Military Clinical Hospital in 2014β2019. All patients long-term suffered from urolithiasis complicated by chronic calculus pyelonephritis in combination with CHD. Clinically significant results of bacteriological urine examinations (CFUβ₯103) were analyzed. The midstream urine specimen cultivation was performed sectorally on Endo agar. The minimum suppressive concentration of the test antibacterial preparations for each of the detected microorganisms was determined by dilution on a dense MΓΌllerβHinton agar culture medium (BBL, USA). The results were processed using the ShapiroβWilk, KolmogorovβSmirnov, and Ο2 Pirson criteria. The values of pβ€0,05 were considered as statistically significant.Results. Specimen culturing revealed Escherichia coli β 24.8%, Klebsiella pneumoniae β 18.3%, Pseudomanas aeruginosa β 11%. Staphylococcus spp., and Enterococcus spp. were most important among gram-positive pathogens (total 26.6% of cases). The sensitivity of the detected infectious agents to basic antibacterial drugs turned out to be sharply reduced. It is noteworthy that 65% of P. aeruginosa strains were sensitive to meropenem.Conclusion. In patients with recurrent urolithiasis combined with CHD, the proportion of gram-positive coccas was increased on the background of calculous pyelonephritis with a simultaneous decrease in the proportion of poly-resistant gram-negative infectious agents (nosocomial strains of E. coli and K. pneumoniae).Π¦Π΅Π»Ρ: Π²ΡΡΠ²ΠΈΡΡ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΊΠ°Π»ΡΠΊΡΠ»Π΅Π·Π½ΠΎΠ³ΠΎ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠ° ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡ ΠΈΡ
Π°Π½ΡΠΈΠ±ΠΈΠΎΡΠΈΠΊΠΎΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΠΎΡΡΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ Π½Π΅ΡΡΠΎΠ»ΠΈΡΠΈΠ°Π·ΠΎΠΌ, ΡΠΎΡΠ΅ΡΠ°ΡΡΠΈΠΌΡΡ Ρ ΠΈΡΠ΅ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ ΡΠ΅ΡΠ΄ΡΠ° (ΠΠΠ‘).ΠΠ°ΡΠ΅ΡΠΈΠ°Π» ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ²Π΅Π΄Π΅Π½ΠΎ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ΅ ΡΠΏΠΈΠ΄Π΅ΠΌΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎ ΡΠΈΠΏΡ Β«ΡΠ»ΡΡΠ°ΠΉβΠΊΠΎΠ½ΡΡΠΎΠ»ΡΒ», Π² ΠΊΠΎΡΠΎΡΠΎΠ΅ Π²ΠΎΡΠ΅Π» 181 ΠΏΠ°ΡΠΈΠ΅Π½Ρ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ ΠΎΡ 57 Π΄ΠΎ 82 Π»Π΅Ρ, ΠΏΡΠΎΠ»Π΅ΡΠ΅Π½Π½ΡΠΉ Π² ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ΅Π½ΡΡΠ΅ ΡΠΈΠ»ΠΈΠ°Π»Π° β 1 ΠΠ»Π°Π²Π½ΠΎΠ³ΠΎ Π²ΠΎΠ΅Π½Π½ΠΎΠ³ΠΎ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ Π³ΠΎΡΠΏΠΈΡΠ°Π»Ρ ΠΈΠΌ. Π°ΠΊΠ°Π΄Π΅ΠΌΠΈΠΊΠ° Π.Π. ΠΡΡΠ΄Π΅Π½ΠΊΠΎ Π² 2014β2019 Π³Π³. ΠΡΠ΅ Π±ΠΎΠ»ΡΠ½ΡΠ΅ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΡΡΡΠ°Π΄Π°Π»ΠΈ ΠΌΠΎΡΠ΅ΠΊΠ°ΠΌΠ΅Π½Π½ΠΎΠΉ Π±ΠΎΠ»Π΅Π·Π½ΡΡ (ΠΠΠ), ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠΉ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΊΠ°Π»ΡΠΊΡΠ»Π΅Π·Π½ΡΠΌ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠΎΠΌ, Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΠΠ‘. ΠΠ·ΡΡΠ΅Π½Ρ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ Π±Π°ΠΊΡΠ΅ΡΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π°Π½Π°Π»ΠΈΠ·ΠΎΠ² ΠΌΠΎΡΠΈ (ΠΠΠβ₯103). ΠΠΎΡΠ΅Π² ΡΡΠ΅Π΄Π½Π΅ΠΉ ΠΏΠΎΡΡΠΈΠΈ ΠΌΠΎΡΠΈ Π²ΡΠΏΠΎΠ»Π½ΡΠ»ΠΈ ΡΠ΅ΠΊΡΠΎΡΠ½ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Π½Π° Π°Π³Π°ΡΠ΅ ΠΠ½Π΄ΠΎ. ΠΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΡ ΠΏΠΎΠ΄Π°Π²Π»ΡΡΡΡΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΡ
Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΡ
ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠΎΠ² Π΄Π»Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΈΠ· Π²ΡΡΠ²Π»Π΅Π½Π½ΡΡ
ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ»ΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ°Π·Π²Π΅Π΄Π΅Π½ΠΈΡ Π½Π° ΠΏΠ»ΠΎΡΠ½ΠΎΠΉ ΠΏΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅Π΄Π΅ Π°Π³Π°ΡΠ° ΠΡΠ»Π»Π΅ΡΠ°βΠ₯ΠΈΠ½ΡΠΎΠ½ (BBL, Π‘Π¨Π). ΠΡΠΈ ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΠΈ ΠΊΡΠΈΡΠ΅ΡΠΈΠΈ Π¨Π°ΠΏΠΈΡΠΎβΠ£ΠΈΠ»ΠΊΠ°, ΠΠΎΠ»ΠΌΠΎΠ³ΠΎΡΠΎΠ²Π°βΠ‘ΠΌΠΈΡΠ½ΠΎΠ²Π° ΠΈ Ο2 ΠΠΈΡΡΠΎΠ½Π°. Π‘ΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈ Π·Π½Π°ΡΠΈΠΌΡΠΌΠΈ ΡΡΠΈΡΠ°Π»ΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΡ Ρβ€0,05.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠΈ ΠΏΠΎΡΠ΅Π²Π΅ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Π²ΡΡΠ²Π»Π΅Π½Ρ: Escherichia coli β Π² 24,8% ΡΠ»ΡΡΠ°Π΅Π², Klebsiella pneumoniae β Π² 18,3%, Pseudomanas aeruginosa β Π² 11%. Π‘ΡΠ΅Π΄ΠΈ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Π΅ΠΉ Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅Π΅ Π·Π½Π°ΡΠ΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅Π»ΠΈ Staphylococcus spp. ΠΈ Enterococcus spp. (ΡΡΠΌΠΌΠ°ΡΠ½ΠΎ 26,6% ΡΠ»ΡΡΠ°Π΅Π²). Π§ΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Π½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
Π°Π³Π΅Π½ΡΠΎΠ² ΠΊ ΠΎΡΠ½ΠΎΠ²Π½ΡΠΌ Π°Π½ΡΠΈΠ±Π°ΠΊΡΠ΅ΡΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ°ΠΌ ΠΎΠΊΠ°Π·Π°Π»Π°ΡΡ ΡΠ΅Π·ΠΊΠΎ ΡΠ½ΠΈΠΆΠ΅Π½Π½ΠΎΠΉ. ΠΠ±ΡΠ°ΡΠ°Π΅Ρ Π½Π° ΡΠ΅Π±Ρ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠΎΡ ΡΠ°ΠΊΡ, ΡΡΠΎ ΠΊ ΠΌΠ΅ΡΠΎΠΏΠ΅Π½Π΅ΠΌΡ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΠΌΠΈ Π±ΡΠ»ΠΈ 65% ΡΡΠ°ΠΌΠΌΠΎΠ² P. aeruginosa.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π£ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΡΠ΅ΡΠΈΠ΄ΠΈΠ²ΠΈΡΡΡΡΠ΅ΠΉ ΠΠΠ Π² ΡΠΎΡΠ΅ΡΠ°Π½ΠΈΠΈ Ρ ΠΠΠ‘ Π½Π° ΡΠΎΠ½Π΅ ΠΊΠ°Π»ΡΠΊΡΠ»Π΅Π·Π½ΠΎΠ³ΠΎ ΠΏΠΈΠ΅Π»ΠΎΠ½Π΅ΡΡΠΈΡΠ° ΡΠ²Π΅Π»ΠΈΡΠ΅Π½Π° Π΄ΠΎΠ»Ρ Π³ΡΠ°ΠΌΠΏΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΠΊΠΎΠΊΠΊΠΎΠ² Ρ ΠΎΠ΄Π½ΠΎΠ²ΡΠ΅ΠΌΠ΅Π½Π½ΡΠΌ ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π΄ΠΎΠ»ΠΈ ΠΏΠΎΠ»ΠΈΡΠ΅Π·ΠΈΡΡΠ΅Π½ΡΠ½ΡΡ
Π³ΡΠ°ΠΌΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
Π°Π³Π΅Π½ΡΠΎΠ² (Π½ΠΎΠ·ΠΎΠΊΠΎΠΌΠΈΠ°Π»ΡΠ½ΡΠ΅ ΡΡΠ°ΠΌΠΌΡ E. coli ΠΈ K. pneumoniae)
Epidemiological aspects of nephrolithiasis and chronic diseases of the cardiovascular system combination
Purpose of the study. To analyze prevalence and characteristics of the cardiovascular diseases (CVD) in patients with urolithiasis, revealed for the first timeMaterials and methods. In a period between 2009 and 2018, was made a retrospective analysis of medical histories of 2311 patients with urolithiasis, which were treated in in the urology departments of the branch No. 1 of the MCHG named after N.N. Burdenko (n=1487) and GBUZ MO Krasnogorsk City Hospital No. 1 (n=824). In 67,6% of the cases (1562 patients) the diagnosis of urolithiasis was diagnosed for the first time on admission. Isolated urolithiasis was recorded in 676 cases (43,3%), in other 154 cases (9,8%) nephrolithiasis was combined with different variants of cardiovascular diseases (CVD) and diabetes. From 732 respondents with urolithiasis and associated cardiovascular diseases (CVD), were formed 3 groups, in the first group (I) were included patients (n=363) with hypertension and arterial hypertension: the second group (II; n=79) was formed from patients with isolated coronary heart disease. In the third group (III) were included 290 patients which had urolithiasis combined with hypertension, arterial hypertension and coronary heart disease. The stages of hypertension and degree of expression of arterial hypertension were given according to the recommendations of Russian science society of cardiology (2004). Stages of congestive heart failure were defined according to c NYHA (New York Heart Association) classification. Functional class of stable angina was defined according to Canadian Cardiovascular Society classification (1970,1976). The obtained data was analyzed using descriptive statistics methods.Results. Average age of patients was 65,4 +β 3,27; 78% of the patients were men. On an emergency basis were hospitalized 30,9% from group I, 27,6% from group 2, and 31,3% from group III. In group I more often were recorded hypertension I + arterial hypertension I (32,5%) and hypertension II + arterial hypertension II (40,2%). In group II effort angina was recorded in 30 cases (38%). Congestive heart failure occurred among 153 patients (20,9%); most often it occurred among patients from III β in 102 cases (35,2%). In the whole sample, congestive heart failure of I and II degrees prevailed β in 88 (12%) and 57 (7,9%) patients. Kidney stones were found in 59,4% of patients, in the ureters β in 30,9% of patients, in kidneys and in the ureters β in 9,9% of patients. Share of the patients with kidney stones in the shape of corals is 3,4% of the whole sample. Average sizes of kidney stones of the patients with congestive heart failure are 9,2β11,8 mm which is different from the sizes in whole sample β 6,9β9,5 mm.Conclusion. During the observation period, share of the patients with first time revealed urolithiasis, complicated with the cardiovascular diseases (CVD) increased in 1,9 times (16,7 versus 31,7%). Congestive heart failure, which was registered in 20,9% of patients, was charged with I and II degrees. The presence chronic cardiovascular diseases (CVD), especially complicated by congestive heart failure in patients with first time revealed nephrolithiasis, implies changes in the algorithms of metaphylactic of nephrolithiasis (regime of water loads, selection of diuretics and anticoagulants)
The Dark Matter of Lab Work: Illuminating the Negotiation of Disciplined Perception in Mechanics
Incidence and risk factors for persistent symptoms in adults previously hospitalized for COVID-19
Background: The long-term sequalae of COVID-19 remain poorly characterized. We assessed persistent symptoms in previously hospitalized patients with COVID-19 and assessed potential risk factors. Methods: Data were collected from patients discharged from 4 hospitals in Moscow, Russia between 8 April and 10 July 2020. Participants were interviewed via telephone using an ISARIC Long-term Follow-up Study questionnaire. Results: 2,649 of 4755 (56%) discharged patients were successfully evaluated, at median 218 (IQR 200, 236) days post-discharge. COVID-19 diagnosis was clinical in 1291 and molecular in 1358. Most cases were mild, but 902 (34%) required supplemental oxygen and 68 (2.6%) needed ventilatory support. Median age was 56 years (IQR 46, 66) and 1,353 (51.1%) were women. Persistent symptoms were reported by 1247 (47.1%) participants, with fatigue (21.2%), shortness of breath (14.5%) and forgetfulness (9.1%) the most common symptoms and chronic fatigue (25%) and respiratory (17.2%) the most common symptom categories. Female sex was associated with any persistent symptom category OR 1.83 (95% CI 1.55 to 2.17) with association being strongest for dermatological (3.26, 2.36 to 4.57) symptoms. Asthma and chronic pulmonary disease were not associated with persistent symptoms overall, but asthma was associated with neurological (1.95, 1.25 to 2.98) and mood and behavioural changes (2.02, 1.24 to 3.18), and chronic pulmonary disease was associated with chronic fatigue (1.68, 1.21 to 2.32). Conclusions: Almost half of adults admitted to hospital due to COVID-19 reported persistent symptoms 6 to 8 months after discharge. Fatigue and respiratory symptoms were most common, and female sex was associated with persistent symptoms