Structural and functional brain changes following four weeks of unimanual motor training: evidence from fMRI-guided diffusion MRI tractography

We have reported reliable changes in behaviour, brain structure and function in 24 healthy right-handed adults who practiced a finger-thumb opposition sequence task with their left hand for 10 mins daily, over four weeks. Here we extend these findings by employing diffusion MRI to investigate white-matter changes in the corticospinal tract, basal-ganglia, and connections of the dorsolateral prefrontal cortex. Twenty-three participant datasets were available with pre-training and post-training scans. Task performance improved in all participants (mean: 52.8%, SD: 20.0%; group

Bias and consistency of the maximum Sharpe ratio

We show that the maximum Sharpe ratio obtained via the Markowitz optimization procedure from a sample of returns on a number of risky assets is, under commonly satisfied assumptions, biased upwards for the population value. Thus investment advice, decisions and assessments based on the estimated Sharpe ratio will be overly optimistic. The bias in the estimator is shown theoretically and illustrated using a data set of Spiders and iShares. We obtain bounds on the difference between the sample maximum Sharpe ratio and its population counterpart and show that the sample estimator is consistent for the population value; thus the bias disappears asymptotically, under some reasonable assumptions. However, the bias can be significant in finite samples and persist even in very large samples. We demonstrate this with simulations based on portfolios formed from normally and t–distributed returns. As expected, the over-optimistic risk-return tradeoff predicted by the procedure is not reflected in corresponding good out-of-sample portfolio performance of the Spiders and iShares

Phase Transitions in a Forest-Fire Model

We investigate a forest-fire model with the density of empty sites as control parameter. The model exhibits three phases, separated by one first-order phase transition and one 'mixed' phase transition which shows critical behavior on only one side and hysteresis. The critical behavior is found to be that of the self-organized critical forest-fire model [B. Drossel and F. Schwabl, Phys. Rev. Lett. 69, 1629 (1992)], whereas in the adjacent phase one finds the spiral waves of the Bak et al. forest-fire model [P. Bak, K. Chen and C. Tang, Phys. Lett. A 147, 297 (1990)]. In the third phase one observes clustering of trees with the fire burning at the edges of the clusters. The relation between the density distribution in the spiral state and the percolation threshold is explained and the implications for stationary states with spiral waves in arbitrary excitable systems are discussed. Furthermore, we comment on the possibility of mapping self-organized critical systems onto 'ordinary' critical systems.Comment: 30 pages RevTeX, 9 PostScript figures (Figs. 1,2,4 are of reduced quality), to appear in Phys. Rev.

First-principles method for high-QQ photonic crystal cavity mode calculations

We present a first-principles method to compute radiation properties of ultra-high quality factor photonic crystal cavities. Our Frequency-domain Approach for Radiation (FAR) can compute the far-field radiation pattern and quality factor of cavity modes $\sim 100$ times more rapidly than conventional finite-difference time domain calculations. It also provides a simple rule for engineering the cavity's far-field radiation pattern

On non-uniform smeared black branes

We investigate charged dilatonic black $p$-branes smeared on a transverse circle. The system can be reduced to neutral vacuum black branes, and we perform static perturbations for the reduced system to construct non-uniform solutions. At each order a single master equation is derived, and the Gregory-Laflamme critical wavelength is determined. Based on the non-uniform solutions, we discuss thermodynamic properties of this system and argue that in a microcanonical ensemble the non-uniform smeared branes are entropically disfavored even near the extremality, if the spacetime dimension is $D \le 13 +p$, which is the critical dimension for the vacuum case. However, the critical dimension is not universal. In a canonical ensemble the vacuum non-uniform black branes are thermodynamically favorable at $D > 12+p$, whereas the non-uniform smeared branes are favorable at $D > 14+p$ near the extremality.Comment: 24 pages, 2 figures; v2: typos corrected, submitted to Class.Quant.Gra

Predictions in SU(5) Supergravity Grand Unification with Proton Stability and Relic Density Constraints

It is shown that in the physically interesting domain of the parameter space of SU(5) supergravity GUT, the Higgs and the Z poles dominate the LSP annihilation. Here the naive analyses on thermal averaging breaks down and formulae are derived which give a rigorous treatment over the poles. These results are then used to show that there exist significant domains in the parameter space where the constraints of proton stability and cosmology are simultaneously satisfied. New upper limits on light particle masses are obtained.Comment: (An error in the reheating factor is corrected, strengthening the conclusions, i.e. the region in parameter space where the relic density constraints are satisfied is enlarged.

Kinetics of the appearance of cereal alkylresorcinols in pig plasma

Alkylresorcinols (AR) are phenolic lipids found in high amounts in wholegrain wheat and rye. They may be important as bioactive components and/or biomarkers of wholegrain wheat and rye intake. AR absorption was studied with pigs during a habitual diet and after a single meal of ARrich diet. In study 1, four pigs were fed wholegrain rye (RD) and white wheat bread (WD) for 1 week in a cross-over design. Arterial and venous AR concentrations were determined over 540 min after feeding on days 5 and 7. In study 2, four pigs were fed a synthetic, starch-based diet for 5 d, and arterial and venous AR concentrations were determined over 960 min after feeding a single meal of RD. In study 1, plasma AR concentrations after consuming RD peaked at 120 min, remained elevated between 120 and 420 min, and were re-elevated on refeeding at 480 min. In study 2, AR appeared in the plasma after 60 min, peaked at 180–240 min, and remained elevated after 960 min. The apparent elimination half-life was 3·93 h, and the maximum plasma concentration was 666 (SEM 35) nmol/l. Arterial and venous plasma AR concentrations were similar, suggesting that AR are absorbed via the lymphatic system. AR concentrations in pig plasma increase rapidly after a meal containing AR, and persist in plasma for at least 5 d, indicating that AR may be a useful biomarker of wholegrain wheat and rye intake.The present study was supported by the Nordic Industrial Fund; the Danish Agricultural and Veterinary Research Council; Cerealia AB, Sweden; Wasabro¨d AB, Sweden; Vaasan & Vaasan, Finland; Fazer Oululainen, Finland. A.-M. L. was supported by the Sigrid Juse´lius Foundation, Helsinki, Finland and Finska La¨karesa¨llskapet, Helsinki, Finland

The generalised NMSSM at one loop: fine tuning and phenomenology

We determine the degree of fine tuning needed in a generalised version of the NMSSM that follows from an underlying Z4 or Z8 R symmetry. We find that it is significantly less than is found in the MSSM or NMSSM and extends the range of Higgs mass that have acceptable fine tuning up to Higgs masses of mh ~ 130 GeV. For universal boundary conditions analogous to the CMSSM the phenomenology is rather MSSM like with the singlet states typically rather heavy. For more general boundary conditions the singlet states can be light, leading to interesting signatures at the LHC and direct detection experiments.Comment: 20 pages, 9 figures, matches published versio