Broadband observations of the X-ray burster 4U 1705-44 with BeppoSAX

4U 1705-44 is one of the most-studied type I X-ray burster and Atoll sources. This source represents a perfect candidate to test different models proposed to self-consistently track the physical changes occurring between different spectral states because it shows clear spectral state transitions. The broadband coverage, the sensitivity and energy resolution of the BeppoSAX satellite offers the opportunity to disentangle the components that form the total X-ray spectrum and to study their changes according to the spectral state. Using two BeppoSAX observations carried out in August and October 2000, respectively, for a total effective exposure time of about 100 ks, we study the spectral evolution of the source from a soft to hard state. Energy spectra are selected according to the source position in the color-color diagram (CCD) Results. We succeeded in modeling the spectra of the source using a physical self-consistent scenario for both the island and banana branches (the double Comptonization scenario). The components observed are the soft Comptonization and hard Comptonization, the blackbody, and a reflection component with a broad iron line. When the source moves from the banana state to the island state, the parameters of the two Comptonization components change significantly and the blackbody component becomes too weak to be detected. We interpret the soft Comptonization component as emission from the hot plasma surrounding the neutron star, hard Comptonization as emission from the disk region, and the blackbody component as emission from the inner accretion disk. The broad feature in the iron line region is compatible with reflection from the inner accretion disk.Comment: 8 pages, 10 figures, accepted for publication by A&

A relativistic iron emission line from the neutron star low-mass X-ray binary GX 3+1

We present the results of a spectroscopic study of the Fe K{\alpha} emission of the persistent neutron-star atoll low-mass X-ray binary and type I X-ray burster GX 3+1 with the EPIC-PN on board XMM-Newton. The source shows a flux modulation over several years and we observed it during its fainter phase, which corresponds to an X-ray luminosity of Lx~10^37 ergs/s. When fitted with a two-component model, the X-ray spectrum shows broad residuals at \sim6-7 keV that can be ascribed to an iron K{\alpha} fluorescence line. In addition, lower energy features are observed at \sim3.3 keV, \sim3.9 keV and might originate from Ar XVIII and Ca XIX. The broad iron line feature is well fitted with a relativistically smeared profile. This result is robust against possible systematics caused by instrumental pile-up effects. Assuming that the line is produced by reflection from the inner accretion disk, we infer an inner disk radius of \sim25 Rg and a disk inclination of 35{\deg} < i < 44{\deg}.Comment: 4 pages, 3 figures Accepted for publication in Astronomy and Astrophysic

Strong Field Gravity and X-Ray Observations of 4U1820-30

The behavior of quasi-periodic oscillations (QPOs) at frequencies near 1 kHz in the x-ray emission from the neutron star x-ray binary 4U1820-30 has been interpreted as evidence for the existence of the marginally stable orbit, a key prediction of strong-field general relativity. The signature of the marginally stable orbit is a saturation in QPO frequency, assumed to track inner disk radius, versus mass accretion rate. Previous studies of 4U1820-30 have used x-ray count rate as an indicator of mass accretion rate. However, x-ray count rate is known to not correlate robustly with mass accretion rate or QPO frequency in other sources. Here, we examine the QPO frequency dependence on two other indicators of mass accretion rate: energy flux and x-ray spectral shape. Using either of these indicators, we find that the QPO frequency saturates at high mass accretion rates. We interpret this as strong evidence for the existence of the marginally stable orbit.Comment: accepted to the Astrophysical Journal Letters, 7 page

Disappearance of Hard X-ray Emission in the Last BeppoSAX Observation of the Z Source GX 349+2

We report on the results from two BeppoSAX observations of the Z source GX 349+2 performed in February 2001 and covering the broad energy range 0.12-200 keV. The light curve obtained from these observations shows a large flaring activity, the count rate varying from ~130 to ~260 counts/s, indicating that the source was in the flaring branch during these observations. The average spectrum is well described by a soft blackbody and a Comptonized component. To well fit the energy spectrum three gaussian lines are needed at 1.2 keV, 2.6 keV, and 6.7 keV with corresponding equivalent widths of 13 eV, 10 eV, and 39 eV, probably associated to L-shell emission of Fe XXIV, Ly-alpha S XVI, and Fe XXV, respectively. These lines may be produced at different distances from the neutron star, which increase when the count rate of the source increases. An absorption edge is also needed at 9 keV with an optical depth of ~3 10^{-2}. From the Color-Color Diagram (CD) we selected five zones from which we extracted the corresponding energy spectra. The temperatures of the blackbody and of the Comptonized component tend to increase when the intensity of the source increases. We discuss our results comparing them to those obtained from a previous BeppoSAX observation, performed in March 2000, during which the source was a similar position of its Z-track. In particular we find that, although the source showed similar spectral states in the 2000 and the 2001 observations, a hard tail, that was significantly detected in March 2000, is not observed in these recent observations.Comment: Accepted for publication on Ap

Dialysis-associated peritonitis in children

Peritonitis remains a frequent complication of peritoneal dialysis in children and is the most common reason for technique failure. The microbiology is characterized by a predominance of Gram-positive organisms, with fungi responsible for less than 5% of episodes. Data collected by the International Pediatric Peritonitis Registry have revealed a worldwide variation in the bacterial etiology of peritonitis, as well as in the rate of culture-negative peritonitis. Risk factors for infection include young age, the absence of prophylactic antibiotics at catheter placement, spiking of dialysis bags, and the presence of a catheter exit-site or tunnel infection. Clinical symptoms at presentation are somewhat organism specific and can be objectively assessed with a Disease Severity Score. Whereas recommendations for empiric antibiotic therapy in children have been published by the International Society of Peritoneal Dialysis, epidemiologic data and antibiotic susceptibility data suggest that it may be desirable to take the patient- and center-specific history of microorganisms and their sensitivity patterns into account when prescribing initial therapy. The vast majority of patients are treated successfully and continue peritoneal dialysis, with the poorest outcome noted in patients with peritonitis secondary to Gram-negative organisms or fungi and in those with a relapsing infection

Decreased humoral immune response in the bronchi of rapid decliners with chronic obstructive pulmonary disease

Background: Identification of COPD patients with a rapid decline in FEV1 is of particular interest for prognostic and therapeutic reasons. Objective: To determine the expression of markers of inflammation in COPD patients with rapid functional decline in comparison to slow or no decliners. Methods: In COPD patients monitored for at least 3&nbsp;years (mean ± SD: 5.8 ± 3&nbsp;years) for lung functional decline, the expression and localization of inflammatory markers was measured in bronchial biopsies of patients with no lung functional decline (FEV1% + 30 ± 43&nbsp;ml/year, n = 21), slow (FEV1% ml/year, −&nbsp;40 ± 19, n = 14) and rapid decline (FEV1% ml/year, −&nbsp;112 ± 53, n = 15) using immunohistochemistry. ELISA test was used for polymeric immunoglobulin receptor (pIgR) quantitation “in vitro”. Results: The expression of secretory IgA was significantly reduced in bronchial epithelium (p = 0.011) and plasma cell numbers was significantly reduced in the bronchial lamina propria (p = 0.017) of rapid decliners compared to no decliners. Bronchial inflammatory cell infiltration, CD4, CD8, CD68, CD20, NK, neutrophils, eosinophils, mast cells, pIgR, was not changed in epithelium and lamina propria of rapid decliners compared to other groups. Plasma cells/mm2 correlated positively with scored total IgA in lamina propria of all patients. “In vitro” stimulation of 16HBE cells with LPS (10&nbsp;μg/ml) and IL-8 (10&nbsp;ng/ml) induced a significant increase while H2O2 (100&nbsp;μM) significantly decreased pIgR epithelial expression. Conclusion: These data show an impaired humoral immune response in rapid decliners with COPD, marked by reduced epithelial secretory IgA and plasma cell numbers in the bronchial lamina propria. These findings may help in the prognostic stratification and treatment of COPD