Poussée de maladie de Kaposi et élévation du CA 19-9: Penser à la tuberculose!

La maladie de Kaposi (MK) est une entité pathologique qui peut survenir chez les patients VIH positifs et dans le cadre d'une immunodépression, d'origine tuberculeuse très rarement. On décrit le cas d'une MK chez un patient VIH négatif au décours d'une tuberculose. Nous rapportons le cas d'un patient âgé de 81 ans, VIH négatif, ayant présenté deux nodules angiomateux de l'avant bras gauche dont la biopsie cutanée était en faveur d'une MK. L'évolution était marquée 2 mois plus tard, par  l'apparition de placards angiomateux extensifs des deux membres supérieurs et d'adénopathies cervicales jugulo-carotidiennes bilatérales. La biopsie ganglionnaire était en faveur d'une  tuberculose ganglionnaire. Par ailleurs, il avait un taux sérique élevé des CA 19-9. La régression de l'étendue des lésions au niveau des membres  supérieurs et la  normalisation du taux sérique des CA 19-9 ont été obtenues sous traitement anti-tuberculeux. Chez les patients atteints d'une MK avec une élévation des CA 19-9, il faut penser à la tuberculose

Page number not for citation purposes 1 Des Furoncles résistants aux antibiotiques: penser à la myiase !!

Les myiases sont des infections parasitaires par des larves de mouches. La localisation cutanée doit être évoquée de retour d'un pays tropical devant une évolution inhabituelle de lésions cutanées. Nous rapportons une observation d'un militaire tunisien, ayant séjourné en République Démocratique du Congo. Il était atteint de myiase cutanée simulatrice d'une furonculose résistante aux antibiotiques. L'intérêt de cette observation est de souligner l'importance d'évoquer la myiase dont le traitement est simple et rapide chez un patient de retour de zone d'endémie.Key words: Furoncles, myiase, mouche

Coexistence of pyoderma gangrenosum and sweet’s syndrome in a patient with ulcerative colitis

Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs. These neutrophilic dermatosis (NDs) are distinguished by the existence of forms of transition or overlap. They are frequently associated to systemic diseases especially hematologic and gastrointestinal ones. We report a case of a patient with ulcerative colitis (UC) who successively developed two types of NDs: PG then SS. A 66 years old patient with a history of UC consulted in July 2012 for an erythematous swelling of the back of the right hand treated with antibiotics without improvement. At that time, bacteriological samples were negative. In October 2012, he was hospitalized for polyarthralgia and impaired general condition. In physical examination, he had vesiculobullous plaque of 10 cm long of the right hand and wrist, infiltrated erythematous plaque on the right leg and another topped with a large pustule at the left ankle. Skin biopsy showed at the back of the right hand an aspect of PG and at the infiltrated plaques of the ankle an aspect of SS. Prednisone was started with improvement of the skin lesions and a recovery condition. The combination of PG and SS has already been described in cases of hematologic malignancy and rarely in UC. There is also the notion of passage from a neutrophilic dermatosis to another. Indeed, a typical lesion initially of SS can evolve to a future PG. This case demonstrates that neutrophilic dermatoses form a continous spectrum of entities that may occur in UC

Impact of hyperhomocysteinemia on histo-morphometry and histochemistry of pancreas in sand rat, Psammomys obesus

Introduction. The sand rat, Psammomys obesus, a diurnal rodent, which lives in the south-east of the Algerian Sahara, is an excellent animal model for the study of diabetes, atherosclerosis, and metabolic syndrome. Hyperhomocysteinemia (Hhcy), defined by high plasma homocysteine level, is associated with many diseases affecting various organs (heart, blood vessels, liver…). Objectives. The objective of this study was to determine the effect of Hhcy on the sand rats pancreas. Material and methods. The rats were divided into two groups: a control group received its natural diet with halophile plant of the Chenopodiacae family (Suaedamollis), and an experimental group received the same diet associated with an intraperitoneal administration of methionine (150 mg/kg body weight/day) during 6 months. Histological and histochemical analysis of Psammomys pancreas were realized and completed by a morphometric study. Results. The methionine excess led to a hyperhomocysteinemia in Psammomys obesus. Several alterations were observed in pancreas extracellular matrix of hyperhomocysteinemic rats, marked by an accumulation of fibrillar collagens, and glycoproteins leading to a fibrosis. This accumulation was observed in the Langerhans islets, and in the exocrine pancreas (interstitial tissue, around blood vessels, and excretory channels). A disorganization of the vascular wall, and a micro- and macrovesicular steatosis were also observed in the pancreas of hyperhomocysteinemic rats. Conclusion. The hyperhomocysteinemia, generated by the methionine excess, leads to a pancreatic extracellular matrix remodeling in Psammomys obesus

High pressure behaviour of elastic and mechanical properties of NiGa intermetallic compound

We have employed the density functional theory plane-wave pseudopotential method with local density approximation and generalized gradient approximation to investigate the structural, elastic and mechanical properties of the intermetallic compound NiGa. The calculated equilibrium lattice constant and bulk modulus are in good agreement with the experimental and other calculated values. According to our best knowledge, from the elastic constants, the bulk modulus B, anisotropy factor A, shear modulus G, the Young modulus E and the Poisson ratio σ for NiGa compound are obtained for the first time. By comparison, our results for the elastic constants C_{ij}, bulk modulus B, shear modulus G and the Young modulus E are as good as those of NiAl compound. The dependences of the elastic and mechanical parameters of NiGa compound on pressure were also investigated. It was found that the cubic NiGa compound is mechanically stable under pressure according to the elastic stability criteria up to 13 GPa, and it is not elastically isotropic. By analyzing the ratio (B/G), it was concluded that NiGa compound is ductile in nature

CALCUL DE L’HELICE MARINE : THEORIE LINEAIRE ET NON LINEAIRE Design of marine propeller : linear and nonlinear theory

L’hélice marine est traitée dans le cadre de la théorie linéaire et non linéaire de la surface portante. Le premiercalcul est traité dans le cadre de la théorie linéaire de la surface portante. Les conditions aux limites sont écritessur la trace de la pale (surface hélicoïdale), et le sillage tourbillonnaire est formé de nappe hélicoïdale à pasconstant. Le deuxième calcul appelé non linéaire est lui effectué en deux parties complémentaires (calculaxisymétrique + calcul 3D singularités). Ce calcul permet de raffiner le tracé de l’hélice obtenu par le premiercalcul en prenant en compte la géométrie des nappes tourbillonnaires du sillage (contraction + étirement), et deseffets tridimensionnels et de l’écoulement amont rotationnel par un couplage entre le calcul axisymétrique et lecalcul 3D singularités. The marine propeller is treated with the linear and nonlinear theory of lifting surface. The first computationmethod based on the model of nonlinear lifting surface theory. The boundary conditions are written in thecamber surface and the trailing vortex wake is considered as a helicoidal surface with a constant pitch. Anonlinear computation is subdivised into two complementary steps (axisymmetric computation + 3D panelmethod). This computation leads to the determination of axisymmetrical stream sheets as well as theapproximate camber surface of the blades. The new aspects developed in this method are the involvement of thecontraction and the stretching of the free vortex wake, the tridimensional effects and the rotational character ofthe incoming flow in the axisymmetric computation with the 3D panel method

Fracture toughness of ABS additively manufactured by FDM process

Purpose: The purpose on this article is to study the failure of FDM printed ABS by exhibiting an exhaustive crack growth analysis mainly based on raster angle parameter. Design/methodology/approach: Two approaches have been developed in this study; On one hand, mechanical experiments were carried out to determine the critical stress intensity factor KIC. On the other hand, numerical analysis was used to predict the paths within the part as well as the crack propagation. Findings: This work has clearly shown the effect of raster angle on the damage mechanism of the ABS printed by FDM. Indeed, for the combination 1 (0°/90°), the structure presents an important stiffness and a high degree of stress distribution symmetry with respect to the notch. Moreover, the crack propagation is regular and straight, and the damage surfaces are on the same plane. However, for the combination 2 (-45°/45°), the structure is less resistant with an asymmetrical stress distribution according to two different planes. Research limitations/implications: In order to present an exhaustive study, we focused on the effect of two raster angles (including 0°/90°, -45°/45°) on the ABS crack propagation, additively manufactured. This study is still in progress for other raster angles, and will be developed from a design of experiments (DoE) design that incorporates all relevant factors. To highlight more the cracking mechanisms, microscopic observations will be developed in more depth. Practical implications: Our analysis can be used as a decision aid in the design of FDM parts. Indeed, we can choose the raster angle that would ensure the desired crack propagation resistance for a functional part. Originality/value: In this article, we have analyzed the mechanism of damage and crack propagation. This topic represents a new orientation for many research papers. For our study, we accompanied our experimental approach with an original numerical approach. In this numerical approach, we were able to mesh distinctly raster by raster for all layers