Sejarah Berdirinya PT. Lpppi dan Pengaruhnya terhadap Perkembangan Sosial-ekonomi Masyarakat Kelurahan Tebingtinggi Kecamatan Tebingtinggi Kabupaten Tanjung Jabung Barat Provinsi Jambi Tahun (1994-2015)

The purpose of this research is (1) to know the history stand up PT. LPPPI at tebingtinggi of subdistrict tebingtinggi of regency tanjung jabung barat Jambi province in the year 1994-2015 (2) to know the influence PT. LPPPI in the field of social-economic of society village at tebingtinggi of subdistrict tebingtinggi of regency tanjung jabung barat Jambi province in the year 1994-2015 (3) to know the negative influence stand up PT. LPPPI at tebingtingi of subdistrict tebingtinggi of regency tanjung jabung barat Jambi province in the year 1994-2015 (4) to know the program of corporate social responsibility (CSR) in village tebingtinggi of subdistrict tebingtinggi of regency tanjung jabung barat Jambi province in the year 1994-2015. In this research method qualitative where this matter will give the complete information so that be of benefit to science. Result from this research is village at tebingtinggi of subdistrict tebingtinggi regency jabung barat Jambi province in the year 1994-2015 experience of a growth in the field of social-economic influence by standing PT. LPPPI with the existence a caring program to society where that company stand up with the program the corporate social responsibility (CSR

Pengaruh Bauran Pemasaran (Produk, Harga, Tempat Dan Proses) Terhadap Minat Beli Ulang Konsumen Pada Warung Bu Darmi Siwalankerto Surabaya

Dengan semakin banyaknya USAha makanan berdiri dan hampir semuanya dipenuhi pengunjung, menyebabkan semakin banyaknya pengusaha yang mulai menekuni bisnis makanan mulai dari tempat makan sederhana hingga mewah. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh bauran pemasaran (produk, harga, tempat dan proses) terhadap minat beli ulang konsumen pada Warung Bu Darmi Siwalankerto Surabaya. Penelitian ini menggunakan metode kuantitatif eksplanatif. Berdasarkan hasil penelitian, diperoleh pengaruh yang signifikan pada bauran pemasaran produk, harga, tempat dan proses terhadap minat beli ulang konsumen. Bauran pemasaran produk berpengaruh dominan terhadap minat beli ulang konsumen pada Warung Bu Darmi Siwalankerto Surabaya

Evidence for modulation of pericryptal sheath myofibroblasts in rat descending colon by Transforming Growth Factor β and Angiotensin II.

BACKGROUND: Absorption of water and Na(+) in descending colonic crypts is dependent on the barrier function of the surrounding myofibroblastic pericryptal sheath. Here the effects of high and low Na(+) diets and exposure to whole body ionising radiation on the growth and activation of the descending colonic pericryptal myofibroblasts are evaluated. In addition the effect of a post-irradiation treatment with the angiotensin converting enzyme inhibitor Captopril was investigated. METHODS: The levels of Angiotensin II type 1 receptor (AT1), ACE, collagen type IV, transforming growth factor-β type 1 receptor (TGF-βR1), OB cadherin and α-smooth muscle actin in both descending colon and caecum were evaluated, using immunocytochemistry and confocal microscopy, in rats fed on high and low Na(+) diets (LS). These parameters were also determined during 3 months post-irradiation with 8Gy from a (60)Co source in the presence and absence of the angiotensin converting enzyme inhibitor, Captopril. RESULTS: Increases in AT1 receptor (135.6% ± 18.3, P < 0.001); ACE (70.1% ± 13.1, P < 0.001); collagen type IV (49.6% ± 15.3, P < 0.001); TGF-β1 receptors (291.0% ± 26.5, P < 0.001); OB-cadherin (26.3% ± 13.8, P < 0.05) and α-smooth muscle actin (82.5% ± 12.4, P < 0.001) were observed in the pericryptal myofibroblasts of the descending colon after LS diet. There are also increases in AT1 receptor and TGF-β1 receptor, smooth muscle actin and collagen type IV after irradiation. Captopril reduced all these effects of irradiation on the pericryptal sheath and also decreased the amount of collagen and smooth muscle actin in control rats (P < 0.001). CONCLUSIONS: These results demonstrate an activation of descending colonic myofibroblasts to trophic stimuli, or irradiation, which can be attenuated by Captopril, indicative of local trophic control by angiotensin II and TGF-β release

The Cholesterol Metabolite 25-Hydroxycholesterol Activates Estrogen Receptor α-Mediated Signaling in Cancer Cells and in Cardiomyocytes

The hydroxylated derivatives of cholesterol, such as the oxysterols, play important roles in lipid metabolism. In particular, 25-hydroxycholesterol (25 HC) has been implicated in a variety of metabolic events including cholesterol homeostasis and atherosclerosis. 25 HC is detectable in human plasma after ingestion of a meal rich in oxysterols and following a dietary cholesterol challenge. In addition, the levels of oxysterols, including 25 HC, have been found to be elevated in hypercholesterolemic serum.Here, we demonstrate that the estrogen receptor (ER) α mediates gene expression changes and growth responses induced by 25 HC in breast and ovarian cancer cells. Moreover, 25 HC exhibits the ERα-dependent ability like 17 β-estradiol (E2) to inhibit the up-regulation of HIF-1α and connective tissue growth factor by hypoxic conditions in cardiomyocytes and rat heart preparations and to prevent the hypoxia-induced apoptosis.The estrogen action exerted by 25 HC may be considered as an additional factor involved in the progression of breast and ovarian tumors. Moreover, the estrogen-like activity of 25 HC elicited in the cardiovascular system may play a role against hypoxic environments