39 research outputs found
Dissipation characteristics of quantized spin waves in nano-scaled magnetic ring structures
The spatial profiles and the dissipation characteristics of spin-wave
quasi-eigenmodes are investigated in small magnetic NiFe ring
structures using Brillouin light scattering microscopy. It is found, that the
decay constant of a mode decreases with increasing mode frequency. Indications
for a contribution of three-magnon processes to the dissipation of higher-order
spin-wave quasi-eigenmodes are found
Direct current control of three magnon scattering processes in spin-valve nanocontacts
We have investigated the generation of spin waves in the free layer of an
extended spin-valve structure with a nano-scaled point contact driven by both
microwave and direct electric current using Brillouin light scattering
microscopy. Simultaneously with the directly excited spin waves, strong
nonlinear effects are observed, namely the generation of eigenmodes with
integer multiple frequencies (2 \emph{f}, 3 \emph{f}, 4 \emph{f}) and modes
with non-integer factors (0.5 \emph{f}, 1.5 \emph{f}) with respect to the
excitation frequency \emph{f}. The origin of these nonlinear modes is traced
back to three magnon scattering processes. The direct current influence on the
generation of the fundamental mode at frequency \emph{f} can be related to the
spin-transfer torque, while the efficiency of three-magnon-scattering processes
is controlled by the Oersted field as an additional effect of the direct
current
Temporal behavior of the inverse spin Hall voltage in a magnetic insulator-nonmagnetic metal structure
It is demonstrated that upon pulsed microwave excitation, the temporal
behavior of a spin-wave induced inverse spin Hall voltage in a magnetic
insulator-nonmagnetic metal structure is distinctly different from the temporal
evolution of the directly excited spin-wave mode from which it originates. The
difference in temporal behavior is attributed to the excitation of long-lived
secondary spin-wave modes localized at the insulator-metal interface
A rare case of arterial avulsion presenting with occult blood loss following total hip arthroplasty: a case report
INTRODUCTION: Iatrogenic arterial damage during total hip replacement is a rare but potentially life- or limb-threatening complication. To the best of our knowledge, this is the first reported case of an avulsion injury to a posterior branch of the profunda femoral artery during primary hip arthroplasty. CASE PRESENTATION: We describe the case of a 55-year-old Caucasian man who underwent a total hip replacement. The patient's hemoglobin levels dropped postoperatively, but there was no obvious bleeding, hemodynamic instability, pulsatile mass, or limb ischemia. The patient's hemoglobin levels continued to drop despite nine units of transfused blood. Three days after surgery, the patient underwent an angiography that showed an avulsion injury to a posterior branch of the profunda femoral artery. The avulsion was ligated and the hematoma was evacuated. CONCLUSION: Vascular damage may present in many ways including obvious bleeding, haemodynamic instability, a pulsatile mass, limb ischemia, and occult blood loss. Any of these signs in isolation or in combination could represent a vascular injury and an urgent angiogram should be considered
Right drug, right patient, right time: aspiration or future promise for biologics in rheumatoid arthritis?
Individualising biologic disease-modifying anti-rheumatic drugs (bDMARDs) to maximise outcomes and deliver safe and cost-effective care is a key goal in the management of rheumatoid arthritis (RA). Investigation to identify predictive tools of bDMARD response is a highly active and prolific area of research. In addition to clinical phenotyping, cellular and molecular characterisation of synovial tissue and blood in patients with RA, using different technologies, can facilitate predictive testing. This narrative review will summarise the literature for the available bDMARD classes and focus on where progress has been made. We will also look ahead and consider the increasing use of ‘omics’ technologies, the potential they hold as well as the challenges, and what is needed in the future to fully realise our ambition of personalised bDMARD treatment
A targeted next-generation sequencing assay for the molecular diagnosis of genetic disorders with orodental involvement.
BACKGROUND: Orodental diseases include several clinically and genetically heterogeneous disorders that can present in isolation or as part of a genetic syndrome. Due to the vast number of genes implicated in these disorders, establishing a molecular diagnosis can be challenging. We aimed to develop a targeted next-generation sequencing (NGS) assay to diagnose mutations and potentially identify novel genes mutated in this group of disorders. METHODS: We designed an NGS gene panel that targets 585 known and candidate genes in orodental disease. We screened a cohort of 101 unrelated patients without a molecular diagnosis referred to the Reference Centre for Oro-Dental Manifestations of Rare Diseases, Strasbourg, France, for a variety of orodental disorders including isolated and syndromic amelogenesis imperfecta (AI), isolated and syndromic selective tooth agenesis (STHAG), isolated and syndromic dentinogenesis imperfecta, isolated dentin dysplasia, otodental dysplasia and primary failure of tooth eruption. RESULTS: We discovered 21 novel pathogenic variants and identified the causative mutation in 39 unrelated patients in known genes (overall diagnostic rate: 39%). Among the largest subcohorts of patients with isolated AI (50 unrelated patients) and isolated STHAG (21 unrelated patients), we had a definitive diagnosis in 14 (27%) and 15 cases (71%), respectively. Surprisingly, COL17A1 mutations accounted for the majority of autosomal-dominant AI cases. CONCLUSIONS: We have developed a novel targeted NGS assay for the efficient molecular diagnosis of a wide variety of orodental diseases. Furthermore, our panel will contribute to better understanding the contribution of these genes to orodental disease. TRIAL REGISTRATION NUMBERS: NCT01746121 and NCT02397824.journal articleresearch support, non-u.s. gov't2016 Feb2015 10 26importe
Abstract Eliciting Confidentiality Requirements in Practice
Confidentiality, the protection of unauthorized disclosure of information, plays an important role in information security of software systems. Security researchers have developed numerous approaches on how to implement confidentiality, typically based on cryptographic algorithms and tight access control. However, less work has been done on defining systematic methods on how to elicit and define confidentiality requirements in the first place. Moreover, most of these approaches are illustrated with simulated examples that do not capture the richness of real world experience. This paper reports on our experiences eliciting confidentiality requirements in a real world project in the health care area. The method applied originates from the M.Sc. thesis of one of the authors and is still considered work in progress. Still, valuable insight into issues of confidentiality requirements engineering can be gained Copyright c ○ 2005 S. Güerses and all other authors named above. Permission to copy is hereby granted provided the original copyright notice is reproduced in copies made. from this case study and we expect that its publication will become a basis for discussion and the definition of a further research agenda in this area.
The monthly incidence of abusive head trauma, inflicted skeletal trauma, and unexplained skin lesion in children in six French university hospitals during the COVID-19 pandemic.
International audienceIntroductionThe COVID-19 pandemic was a stressful period. Lockdowns may have added to parental difficulty leading to an increase in violence. This study aimed to compare the monthly incidence of high suspicion of child physical abuse before and during the COVID-19 pandemic.MaterialWe have retrospectively reviewed imaging examinations of children having a skeletal X-ray examination in six university hospitals with high suspicion of abusive head traumatism (AHT), inflicted skeletal trauma (IST) and unexplained skin lesions (USL) between March 2020 and June 2021 and compared with the similar period from 2018 to 2019. The monthly incidence of the different physical maltreatment was analyzed using a QuasiPoisson regression model.ResultsWe included 178 children (n = 127 boys, 71.3 %), 110 during the pandemic period, median age 5 months. AHT was diagnosed in 91 children, 55 had inflicted skeletal trauma (IST) and 46 had unexplained skin lesions (USL). Among the 91 patients with AHT, 86 had a subdural hematoma (95.6 %) and 40 had bridging veins thrombosis (44 %). The ophthalmological examination performed on 89 children (97.9 %) revealed retinal hemorrhages in 57 children (89.8 %). The incidence of AHT doubled during the months of COVID-19 lockdowns (rate ratio = 2; 95 % CI [1.1; 3.6], p = 0.03). No difference in monthly incidence was observed for IST and USL groups.ConclusionA significant increase in AHT was observed during the months with lockdowns and curfews during the COVID-19 pandemic. This highlights the need for developing a national strategy to prevent physical abuse in children in this context