Conformational studies of various hemoglobins by natural-abundance 13C NMR spectroscopy

Studies of variously liganded hemoglobins (both from human and rabbit) by natural-abundance 13C NMR spectroscopy have revealed apparent conformational differences that have been interpreted on the basis of two quaternary structures for the α2ß2 tetramer, and variable tertiary structures for the individual α and ß subunits. In solution, rabbit hemoglobins appear to have somewhat more flexibility than human hemoglobins

Velocity Distributions and Correlations in Homogeneously Heated Granular Media

We compare the steady state velocity distributions from our three-dimensional inelastic hard sphere molecular dynamics simulation for homogeneously heated granular media, with the predictions of a mean field-type Enskog-Boltzmann equation for inelastic hard spheres [van Noije & Ernst, Gran. Matt. {\bf 1}, 57 (1998)]. Although we find qualitative agreement for all values of density and inelasticity, the quantitative disagreement approaches $\sim 40$ at high inelasticity or density. By contrast the predictions of the pseudo-Maxwell molecule model [Carrillo, Cercignani & Gamba, Phys. Rev. E, {\bf 62}, 7700 (2000)] are both qualitatively and quantitatively different from those of our simulation. We also measure short-range and long-range velocity correlations exhibiting non-zero correlations at contact before the collision, and being consistent with a slow algebraic decay over a decade in the unit of the diameter of the particle, proportional to $r^{-(1+\alpha)}$, where $0.2 < \alpha < 0.3$. The existence of these correlations imply the failure of the molecular chaos assumption and the mean field approximation, which is responsible for the quantitative disagreement of the inelastic hard sphere kinetic theory.Comment: 23 pages, 15 figures, Phys. Rev. E, in pres

Standing on the Shoulders of Giants: The Cleft Palate-Craniofacial Journal (1964-1989)Electronic Archive

Current research and clinical practice in cleft palate and craniofacial disorders “stands on the shoulders of giants” who came before us. To enable thirty years of seminal research articles to become digitally available to a worldwide community of students, scholars, and clinicians, a collaboration was forged in 2004 between University of Pittsburgh’s Digital Research Library (DRL) and ACPA, (with the agreement of Allen Press), to create an electronic archive of the first thirty years of the Cleft Palate Craniofacial Journal . The work was performed pro bono, by all parties

Design, development and performance study of six-gap glass MRPC detectors

The Multigap Resistive Plate Chambers (MRPCs) are gas ionization detectors with multiple gas sub-gaps made of resistive electrodes. The high voltage (HV) is applied on the outer surfaces of outermost resistive plates only, while the interior plates are left electrically floating. The presence of multiple narrow sub--gaps with high electric field results in faster signals on the outer electrodes, thus improving the detector's time resolution. Due to their excellent performance and relatively low cost, the MRPC detector has found potential application in Time-of-Flight (TOF) systems. Here we present the design, fabrication, optimization of the operating parameters such as the HV, the gas mixture composition, and, performance of six--gap glass MRPC detectors of area 27cm $\times$ 27 cm, which are developed in order to find application as trigger detectors, in TOF measurement etc. The design has been optimized with unique spacers and blockers to ensure a proper gas flow through the narrow sub-gaps, which are 250 $\mu$m wide. The gas mixture consisting of R134A, Isobutane and SF$_{6}$, and the fraction of each constituting gases has been optimized after studying the MRPC performance for a set of different concentrations. The counting efficiency of the MRPC is about 95% at $17.9$ kV. At the same operating voltage, the time resolution, after correcting for the walk effect, is found to be about $219$ ps.Comment: Revised version with 15 pages, 14 figures, 2 tables. Accepted for publication in the European Physical Journal

Stable pseudoanalytical computation of electromagnetic fields from arbitrarily-oriented dipoles in cylindrically stratified media

Computation of electromagnetic fields due to point sources (Hertzian dipoles) in cylindrically stratified media is a classical problem for which analytical expressions of the associated tensor Green's function have been long known. However, under finite-precision arithmetic, direct numerical computations based on the application of such analytical (canonical) expressions invariably lead to underflow and overflow problems related to the poor scaling of the eigenfunctions (cylindrical Bessel and Hankel functions) for extreme arguments and/or high-order, as well as convergence problems related to the numerical integration over the spectral wavenumber and to the truncation of the infinite series over the azimuth mode number. These problems are exacerbated when a disparate range of values is to be considered for the layers' thicknesses and material properties (resistivities, permittivities, and permeabilities), the transverse and longitudinal distances between source and observation points, as well as the source frequency. To overcome these challenges in a systematic fashion, we introduce herein different sets of range-conditioned, modified cylindrical functions (in lieu of standard cylindrical eigenfunctions), each associated with non-overlapped subdomains of (numerical) evaluation to allow for stable computations under any range of physical parameters. In addition adaptively-chosen integration contours are employed in the complex spectral wavenumber plane to ensure convergent numerical integration in all cases. We illustrate the application of the algorithm to problems of geophysical interest involving layer resistivities ranging from 1000 $\Omega \cdot$m to 10$^{-8} \Omega \cdot$m, frequencies of operation ranging from 10 MHz down to the low magnetotelluric range of 0.01 Hz, and for various combinations of layer thicknesses.Comment: 33 pages, 23 figures. This v2 is slightly condensed and has some material moved to the Appendice

Ergodic property of Markovian semigroups on standard forms of von Neumann algebras

We give sufficient conditions for ergodicity of the Markovian semigroups associated to Dirichlet forms on standard forms of von Neumann algebras constructed by the method proposed in Refs. [Par1,Par2]. We apply our result to show that the diffusion type Markovian semigroups for quantum spin systems are ergodic in the region of high temperatures where the uniqueness of the KMS-state holds.Comment: 25 page

Reentrant Melting of Soliton Lattice Phase in Bilayer Quantum Hall System

At large parallel magnetic field $B_\parallel$, the ground state of bilayer quantum Hall system forms uniform soliton lattice phase. The soliton lattice will melt due to the proliferation of unbound dislocations at certain finite temperature leading to the Kosterlitz-Thouless (KT) melting. We calculate the KT phase boundary by numerically solving the newly developed set of Bethe ansatz equations, which fully take into account the thermal fluctuations of soliton walls. We predict that within certain ranges of $B_\parallel$, the soliton lattice will melt at $T_{\rm KT}$. Interestingly enough, as temperature decreases, it melts at certain temperature lower than $T_{\rm KT}$ exhibiting the reentrant behaviour of the soliton liquid phase.Comment: 11 pages, 2 figure

Books Received

We investigate the persistence of spectral gaps of one-dimensional frustration free quantum lattice systems under weak perturbations and with open boundary conditions. Assuming that the interactions of the system satisfy a form of local topological quantum order, we prove explicit lower bounds on the ground state spectral gap and higher gaps for spin and fermion chains. By adapting previous methods using the spectral flow, we analyze the bulk and edge dependence of lower bounds on spectral gaps

Skewed Factor Models Using Selection Mechanisms

Traditional factor models explicitly or implicitly assume that the factors follow a multivariate normal distribution; that is, only moments up to order two are involved. However, it may happen in real data problems that the first two moments cannot explain the factors. Based on this motivation, here we devise three new skewed factor models, the skew-normal, the skew-t, and the generalized skew-normal factor models depending on a selection mechanism on the factors. The ECME algorithms are adopted to estimate related parameters for statistical inference. Monte Carlo simulations validate our new models and we demonstrate the need for skewed factor models using the classic open/closed book exam scores dataset