94 research outputs found
Factors associated with recurrence and survival length following relapse in patients with neuroblastoma
Background: Despite therapeutic advances, survival following relapse for neuroblastoma patients remains poor. We investigated clinical and biological factors associated with length of progression-free and overall survival following relapse in UK neuroblastoma patients. Methods: All cases of relapsed neuroblastoma, diagnosed during 1990-2010, were identified from four Paediatric Oncology principal treatment centres. Kaplan-Meier and Cox regression analyses were used to calculate post-relapse overall survival (PROS), post-relapse progression-free survival (PRPFS) between relapse and further progression, and to investigate influencing factors. Results: One hundred eighty-nine cases were identified from case notes, 159 (84.0%) high risk and 17 (9.0%), unresectable, MYCN non-amplified (non-MNA) intermediate risk (IR). For high-risk patients diagnosed >2000, median PROS was 8.4 months (interquartile range (IQR)=3.0-17.4) and median PRPFS was 4.7 months (IQR=2.1-7.1). For IR, unresectable non-MNA patients, median PROS was 11.8 months (IQR 9.0-51.6) and 5-year PROS was 24% (95% CI 7-45%). MYCN amplified (MNA) disease and bone marrow metastases at diagnosis were independently associated with worse PROS for high-risk cases. Eighty percent of high-risk relapses occurred within 2 years of diagnosis compared with 50% of unresectable non-MNA IR disease. Conclusions: Patients with relapsed HR neuroblastomas should be treatment stratified according to MYCN status and PRPFS should be the primary endpoint in early phase clinical trials. The failure to salvage the majority of IR neuroblastoma is concerning, supporting investigation of intensification of upfront treatment regimens in this group to determine whether their use would diminish likelihood of relapse
Targeted 18O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometry
High Precision Quantitative Proteomics Using iTRAQ on an LTQ Orbitrap: A New Mass Spectrometric Method Combining the Benefits of All
Laypeople’s Evaluation of Arguments: Are Criteria for Argument Quality Scheme-Specific?
Differential protein expression analysis using stable isotope labeling and PQD linear ion trap MS technology
A systematic framework to derive N-glycan biosynthesis process and the automated construction of glycosylation networks
Prostate protein n-glycosylation profiling by means of DNA sequencer-assisted fluorophore-assisted carbohydrate electrophoresis
Hybrid integration for heralded single photon generation
We report a hybrid integrated source of heralded photons at telecom wavelengths. We have combined high efficiency periodically poled lithium niobate (PPLN) waveguides, low-loss laser inscribed circuits and fibre Bragg gratings. We show the quality of the laser written components to be sufficient to produce high quality heralded single photons.2 page(s
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