1,114 research outputs found
Surface Oscillations in Overdense Plasmas Irradiated by Ultrashort Laser Pulses
The generation of electron surface oscillations in overdense plasmas
irradiated at normal incidence by an intense laser pulse is investigated.
Two-dimensional (2D) particle-in-cell simulations show a transition from a
planar, electrostatic oscillation at , with the laser
frequency, to a 2D electromagnetic oscillation at frequency and
wavevector . A new electron parametric instability, involving the
decay of a 1D electrostatic oscillation into two surface waves, is introduced
to explain the basic features of the 2D oscillations. This effect leads to the
rippling of the plasma surface within a few laser cycles, and is likely to have
a strong impact on laser interaction with solid targets.Comment: 9 pages (LaTeX, Revtex4), 4 GIF color figures, accepted for
publication in Phys. Rev. Let
Adaptive filtering techniques for gravitational wave interferometric data: Removing long-term sinusoidal disturbances and oscillatory transients
It is known by the experience gained from the gravitational wave detector
proto-types that the interferometric output signal will be corrupted by a
significant amount of non-Gaussian noise, large part of it being essentially
composed of long-term sinusoids with slowly varying envelope (such as violin
resonances in the suspensions, or main power harmonics) and short-term ringdown
noise (which may emanate from servo control systems, electronics in a
non-linear state, etc.). Since non-Gaussian noise components make the detection
and estimation of the gravitational wave signature more difficult, a denoising
algorithm based on adaptive filtering techniques (LMS methods) is proposed to
separate and extract them from the stationary and Gaussian background noise.
The strength of the method is that it does not require any precise model on the
observed data: the signals are distinguished on the basis of their
autocorrelation time. We believe that the robustness and simplicity of this
method make it useful for data preparation and for the understanding of the
first interferometric data. We present the detailed structure of the algorithm
and its application to both simulated data and real data from the LIGO 40meter
proto-type.Comment: 16 pages, 9 figures, submitted to Phys. Rev.
A Femtosecond Neutron Source
The possibility to use the ultrashort ion bunches produced by circularly
polarized laser pulses to drive a source of fusion neutrons with sub-optical
cycle duration is discussed. A two-side irradiation of a thin foil deuterated
target produces two countermoving ion bunches, whose collision leads to an
ultrashort neutron burst. Using particle-in-cell simulations and analytical
modeling, it is evaluated that, for intensities of a few ,
more than neutrons per Joule may be produced within a time shorter than
one femtosecond. Another scheme based on a layered deuterium-tritium target is
outlined.Comment: 15 pages, 3 figure
Meadowdale High School Student with Disabilities Finds Job in UD Cafeteria; UD Assistant Geology Professor Plots City\u27s Glacial Deposits on High-Tech Map
Feature leads for the media: The University of Dayton and Dayton Public Schools have teamed up to place a Meadowdale High School student with multiple disabilities in a job with Kennedy Union Food Service; UD geology faculty member J. Michael Clinch is using a computer to create Dayton and Montgomery County\u27s first extensive and only automated inventory of glacial and post-glacial deposits on a U.S. Geological Survey base map
D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent
We have recently found that D(-)lentiginosine, a synthetic iminosugar exerting glucosidase inhibitory activity, but not its natural enantiomer lentiginosine, is endowed with an unexpected, pro-apoptotic activity. Here, we investigated mechanisms involved in apoptosis induced by D(-)lentiginosine in MOLT-3, HT-29 and SH-SY5Y tumour cell lines. The results showed that D(-)lentiginosine increased caspase 9 expression at 18 h in all the cell lines from 1.5-3.1 folds. Cytochrome c in the cytoplasm was found to be increased from 2.3-2.6 folds in treated cells with respect to control cells. These effects were accompanied by a remarkable collapse of the mitochondrial membrane potential and by the downregulation of anti-apoptotic genes, as well as the upregulation of pro-apoptotic genes of the Bcl-2 family. U937Bcl-2 transfectants, highly expressing Bcl-2, were reluctant to undergo apoptosis even following treatment with 500 μM D(-)lentiginosine, whereas apoptosis by D(-)lentiginosine was induced also in U937 cells, naturally deficient in P53. Thus, our study establishes that the enantiomer of a natural iminosugar is endowed with a possible anti-tumorigenic effect that might be ascribed not only to their capacity to inhibit glycosidases but also to other unknown mechanisms. These data encourage further investigation on similar compounds to make them an interesting platform for the generation of new anticancer drugs
Enantiomerically pure phosphonated carbocyclic 2'-oxa-3'-azanucleosides: synthesis and biological evaluation
Starting from enantiomeric pure 1-[(3S,5R)- and 1-[(3R,5S)-3-(hydroxymethyl)-2-methylisoxazolidin-5-yl]-5-methylpyrimidine-2,4(1H,3H)-diones (-)7a and (+)7b, obtained by lipase-catalyzed resolution, pure diethyl{[(3S,5R)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)isoxazolidin-3-yl]methyl}phosphonate (-)12a and diethyl{[(3R,5S)-2-methyl-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)isoxazolidin-3-yl]methyl}phosphonate (+)12b have been synthesized. The obtained compounds showed no cytotoxic activity versus the U937 cell line in comparison with AZT, and were poorly able to inhibit HIV infection in vitro
Eynard-Mehta theorem, Schur process, and their pfaffian analogs
We give simple linear algebraic proofs of Eynard-Mehta theorem,
Okounkov-Reshetikhin formula for the correlation kernel of the Schur process,
and Pfaffian analogs of these results. We also discuss certain general
properties of the spaces of all determinantal and Pfaffian processes on a given
finite set.Comment: AMSTeX, 21 pages, a new section adde
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