2,388 research outputs found
The Saudi State as an Identity Racketeer
Where substantial research has examined the Saudi state’s symbiosis with the Islamic revivalist movement commonly known as ‘Wahhabism’, little has considered how the dynamics of state formation underpin this relationship. This article argues that a continuous and circular political logic sits behind the Saudi state’s patronage of the revivalist movement since 1744. It proposes a four-stage model that explains how and why the Saudi state has maintained its support of the revivalist movement over this prolonged period. This article will first outline this model, before moving to a detailed analysis of the development of Saudi state authority to highlight the recurrent manner in which the spiritual concerns of revivalists have often been constructed by the state to counter challenges to its authority, a pattern showcased most recently during the Arab Spring and the war in Yemen. The relevance of this model persists today, and will continue to shape the decisions, policies and perceptions of the Saudi political elite for the foreseeable future
Significance analysis and statistical mechanics: an application to clustering
This paper addresses the statistical significance of structures in random
data: Given a set of vectors and a measure of mutual similarity, how likely
does a subset of these vectors form a cluster with enhanced similarity among
its elements? The computation of this cluster p-value for randomly distributed
vectors is mapped onto a well-defined problem of statistical mechanics. We
solve this problem analytically, establishing a connection between the physics
of quenched disorder and multiple testing statistics in clustering and related
problems. In an application to gene expression data, we find a remarkable link
between the statistical significance of a cluster and the functional
relationships between its genes.Comment: to appear in Phys. Rev. Let
An Abstract Interpretation for ML Equality Kinds
The definition of Standard ML provides a form of generic equality which is inferred for certain types, called equality types, on which it is possible to define an equality relation in ML. However, the standard definition is incomplete in the sense that there are interesting and useful types which are not inferred to be equality types but for which an equality relation can be defined in ML in a uniform manner. In this paper, a refinement of the Standard ML system of equality types is introduced and is proven sound and complete with respect to the existence of a definable equality. The technique used here is based on an abstract interpretation of ML operators as monotone functions over a three point lattice. It is shown how the equality relation can be defined (as an ML program) from the definition of a type with our equality property. Finally, a sound, efficient algorithm for inferring the equality property which corrects the limitations of the standard definition in all cases of practical interest is demonstrated
Coarse Graining for Synchronization in Directed Networks
Coarse graining model is a promising way to analyze and visualize large-scale
networks. The coarse-grained networks are required to preserve the same
statistical properties as well as the dynamic behaviors as the initial
networks. Some methods have been proposed and found effective in undirected
networks, while the study on coarse graining in directed networks lacks of
consideration. In this paper, we proposed a Topology-aware Coarse Graining
(TCG) method to coarse grain the directed networks. Performing the linear
stability analysis of synchronization and numerical simulation of the Kuramoto
model on four kinds of directed networks, including tree-like networks and
variants of Barab\'{a}si-Albert networks, Watts-Strogatz networks and
Erd\"{o}s-R\'{e}nyi networks, we find our method can effectively preserve the
network synchronizability.Comment: 9 pages, 7 figure
A New Approach to Time Domain Classification of Broadband Noise in Gravitational Wave Data
Broadband noise in gravitational wave (GW) detectors, also known as triggers,
can often be a deterrant to the efficiency with which astrophysical search
pipelines detect sources. It is important to understand their instrumental or
environmental origin so that they could be eliminated or accounted for in the
data. Since the number of triggers is large, data mining approaches such as
clustering and classification are useful tools for this task. Classification of
triggers based on a handful of discrete properties has been done in the past. A
rich information content is available in the waveform or 'shape' of the
triggers that has had a rather restricted exploration so far. This paper
presents a new way to classify triggers deriving information from both trigger
waveforms as well as their discrete physical properties using a sequential
combination of the Longest Common Sub-Sequence (LCSS) and LCSS coupled with
Fast Time Series Evaluation (FTSE) for waveform classification and the
multidimensional hierarchical classification (MHC) analysis for the grouping
based on physical properties. A generalized k-means algorithm is used with the
LCSS (and LCSS+FTSE) for clustering the triggers using a validity measure to
determine the correct number of clusters in absence of any prior knowledge. The
results have been demonstrated by simulations and by application to a segment
of real LIGO data from the sixth science run.Comment: 16 pages, 16 figure
Population genetics of the highly polymorphic RPP8 gene family
Plant nucleotide-binding domain and leucine-rich repeat containing (NLR) genes provide some of the most extreme examples of polymorphism in eukaryotic genomes, rivalling even the vertebrate major histocompatibility complex. Surprisingly, this is also true in Arabidopsis thaliana, a predominantly selfing species with low heterozygosity. Here, we investigate how gene duplication and intergenic exchange contribute to this extraordinary variation. RPP8 is a three-locus system that is configured chromosomally as either a direct-repeat tandem duplication or as a single copy locus, plus a locus 2 Mb distant. We sequenced 48 RPP8 alleles from 37 accessions of A. thaliana and 12 RPP8 alleles from Arabidopsis lyrata to investigate the patterns of interlocus shared variation. The tandem duplicates display fixed differences and share less variation with each other than either shares with the distant paralog. A high level of shared polymorphism among alleles at one of the tandem duplicates, the single-copy locus and the distal locus, must involve both classical crossing over and intergenic gene conversion. Despite these polymorphism-enhancing mechanisms, the observed nucleotide diversity could not be replicated under neutral forward-in-time simulations. Only by adding balancing selection to the simulations do they approach the level of polymorphism observed at RPP8. In this NLR gene triad, genetic architecture, gene function and selection all combine to generate diversity
Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapine
<p>Abstract</p> <p>Background</p> <p>The purpose of the study was to determine the effectiveness and tolerability of quetiapine as a maintenance treatment preventing against relapse or recurrence of acute mood episodes in adolescent patients diagnosed with bipolar disorder.</p> <p>Methods</p> <p>Consenting patients meeting DSM-IV lifetime criteria for a bipolar disorder and clinically appropriate for maintenance treatment were enrolled in a 48-week open prospective study. After being acutely stabilized (CGI-S ≤ 3 for 4 consecutive weeks), patients were started or continued on quetiapine and other medications were weaned off over an 8-week period. Quetiapine monotherapy was continued for 40-weeks and other mood stabilizers or antidepressants were added if clinically indicated. A neurocognitive test battery assessing the most reliable findings in adult patients was administered at fixed time points throughout the study to patients and matched controls.</p> <p>Results</p> <p>Of the 21 enrolled patients, 18 completed the 48-week study. Thirteen patients were able to be maintained without relapse or recurrence in good quality remission on quetiapine monotherapy, while 5 patients required additional medication to treat impairing residual depressive and/or anxiety symptoms. According to symptom ratings and global functioning scores, the quality of remission for all patients was very good.</p> <p>Neurocognitive test performance over treatment was equivalent to that of a matched control group of never ill adolescents. Quetiapine was generally well tolerated with no serious adverse effects.</p> <p>Conclusion</p> <p>This study suggests that a proportion of adolescent patients diagnosed with bipolar disorder can be successfully maintained on quetiapine monotherapy. The good quality of clinical remission and preserved neurocognitive functioning underscores the importance of early diagnosis and effective stabilization.</p> <p>Clinical Trials Registry</p> <p>D1441L00024</p
Exploring The Frequency Of Close-In Jovian Planets Around M Dwarfs
We discuss our high precision radial velocity results of a sample of 90 M dwarfs observed with the Hobby-Eberly Telescope and the Harlan J. Smith 2.7 m Telescope at McDonald Observatory, as well as the ESO VLT and the Keck I telescopes, within the context of the overall frequency of Jupiter-mass planetary companions to main sequence stars. None of the stars in our sample show variability indicative of a giant planet in a short period orbit, with a 3.8 M_Jup and a 3.5 M_Jup and a < 0.7 AU. Our results point toward a generally lower frequency of close-in Jovian planets for M dwarfs as compared to FGK-type stars. This is an important piece of information for our understanding of the process of planet formation as a function of stellar mass
Long-lived, long-period radial velocity variations in Aldebaran: A planetary companion and stellar activity
We investigate the nature of the long-period radial velocity variations in
Alpha Tau first reported over 20 years ago. We analyzed precise stellar radial
velocity measurements for Alpha Tau spanning over 30 years. An examination of
the Halpha and Ca II 8662 spectral lines, and Hipparcos photometry was also
done to help discern the nature of the long-period radial velocity variations.
Our radial velocity data show that the long-period, low amplitude radial
velocity variations are long-lived and coherent. Furthermore, Halpha equivalent
width measurements and Hipparcos photometry show no significant variations with
this period. Another investigation of this star established that there was no
variability in the spectral line shapes with the radial velocity period. An
orbital solution results in a period of P = 628.96 +/- 0.90 d, eccentricity, e
= 0.10 +/- 0.05, and a radial velocity amplitude, K = 142.1 +/- 7.2 m/s.
Evolutionary tracks yield a stellar mass of 1.13 +/- 0.11 M_sun, which
corresponds to a minimum companion mass of 6.47 +/- 0.53 M_Jup with an orbital
semi-major axis of a = 1.46 +/- 0.27 AU. After removing the orbital motion of
the companion, an additional period of ~ 520 d is found in the radial velocity
data, but only in some time spans. A similar period is found in the variations
in the equivalent width of Halpha and Ca II. Variations at one-third of this
period are also found in the spectral line bisector measurements. The 520 d
period is interpreted as the rotation modulation by stellar surface structure.
Its presence, however, may not be long-lived, and it only appears in epochs of
the radial velocity data separated by 10 years. This might be due to an
activity cycle. The data presented here provide further evidence of a planetary
companion to Alpha Tau, as well as activity-related radial velocity variations.Comment: 18 pages, 14 figures. Accepted for publication in Astronomy and
Astrophysic
The Kepler Follow-up Observation Program
The Kepler Mission was launched on March 6, 2009 to perform a photometric
survey of more than 100,000 dwarf stars to search for terrestrial-size planets
with the transit technique. Follow-up observations of planetary candidates
identified by detection of transit-like events are needed both for
identification of astrophysical phenomena that mimic planetary transits and for
characterization of the true planets and planetary systems found by Kepler. We
have developed techniques and protocols for detection of false planetary
transits and are currently conducting observations on 177 Kepler targets that
have been selected for follow-up. A preliminary estimate indicates that between
24% and 62% of planetary candidates selected for follow-up will turn out to be
true planets.Comment: 12 pages, submitted to the Astrophysical Journal Letter
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