Temporal trend in the transfer of Sellafield-derived 14C into different size fractions of the carbonate component of NE Irish Sea sediment

From 1994 onwards, 14C discharges from the Sellafield nuclear fuel reprocessing plant have been made largely to the Northeast Irish Sea. They represent the largest contributor to UK and European populations of the collective dose commitment derived from the entire nuclear industry discharges. Consequently, it is important to understand the long-term fate of 14C in the marine environment. Research undertaken in 2000 suggested that the carbonate component of Northeast Irish Sea sediments would increase in 14C activity as mollusc shells, which have become enriched in Sellafield-derived 14C, are broken down by physical processes including wave action and incorporated into intertidal and sub-tidal sediments. The current study, undertaken in 2011, tested this hypothesis. The results demonstrate significant increases in 14C enrichments found in whole mussel shells compared to those measured in 2000. Additionally, in 2000, there was an enrichment above ambient background within only the largest size fraction (>500 μm) of the intertidal inorganic sediment at Nethertown and Flimby (north of Sellafield). In comparison, the present study has demonstrated 14C enrichments above ambient background in most size fractions at sites up to 40 km north of Sellafield, confirming the hypothesis set out more than a decade ago

Association of executive function impairment, history of falls and physical performance in older adults: A cross-sectional population-based study in Eastern France

To estimate: 1) the association between executive function (EF) impairment and falls; and 2) the association of EF impairment on tests of physical function used in the evaluation of fall risk.Cross-sectional study. Thirteen health examination centres in Eastern France. Four thousand four hundred and eighty one community-dwelling older adults without dementia aged 65 to 97 years (mean age 71.8 +/- 5.4, women 47.6%). Participants underwent a comprehensive medical assessment that included evaluations of EF using the Clock Drawing Test and of physical performance using the Timed Up & Go Test (TUG). Analysis used multivariable modified Poisson regression to evaluate the association between impaired EF and each of the fall outcomes (any fall, recurrent falls, fall-related injuries). Multivariable linear regression was used to evaluate the association between EF impairment and performance on the TUG and grip strength. EF impairment, assessed using the clock drawing test, was present in 24.9% of participants. EF impairment was independently associated with an increased risk of any fall (RR=1.13, 95% CI (1.03, 1.25)) and major soft tissue fall-related injury (RR= 2.42, 95% CI (1.47, 4.00)). Additionally, EF impairment was associated with worse performance on the TUG (p < 0.0001). EF impairment among older adults without dementia was highly prevalent and was independently associated with an increased risk for falls, fall-related injuries and with decreased physical function. The use of the Clock Drawing Test is an easy to administer measure of EF that can be used routinely in comprehensive fall risk evaluations

Complementary Organic Logic Gates on Plastic Formed by Self-Aligned Transistors with Gravure and Inkjet Printed Dielectric and Semiconductors

Complementary organic field-effect transistors, inverters, NAND and NOR logic on plastic are demonstrated using a combination of nanoimprint lithography, self-alignment, gravure, and inkjet printing. Sub-micrometer channel lengths, electrode overlaps and sub-100 nm dielectrics are compared to photolithographically patterned equivalents, as are inkjet and gravure printed semiconductors

High Energy Secondaries for the Quantitative Secondary Ion Mass Spectrometric Analysis of Minerals

The major hurdle in quantitative analysis by SIMS is the inconsistency and non-predictability of ion yields, particularly their sensitivity to sample matrix. High energy (100-500 eV) secondary ions have been shown to be considerably less susceptible to matrix effects than low energy secondary ions, particularly in mineral analysis. Therefore ion yields of some sixty elements were measured utilizing very high energy secondaries (~ 500 eV), from a standard silicate glass. They show a broad ionization potential dependence and a mass (or velocity) dependency which is not removed by the application of a M½ or M factor. The modification of yields with conventional thermodynamic partition functions, improves but does not clearly define agreement with the inverse exponential relationship observed by others, for low energy secondaries sputtered from oxygen rich matrices. The reproducibility of ion yields of high energy secondaries suggests empirical approaches to quantitative analysis are well justified; however the poor agreement of ion yields with an inverse exponential relationship, suggests that ion yielding mechanisms are somewhat different to those proposed in the low energy regime

Transcriptomic Analysis of Peritoneal Cells in a Mouse Model of Sepsis: Confirmatory and Novel Results in Early and Late Sepsis.

Background The events leading to sepsis start with an invasive infection of a primary organ of the body followed by an overwhelming systemic response. Intra-abdominal infections are the second most common cause of sepsis. Peritoneal fluid is the primary site of infection in these cases. A microarray-based approach was used to study the temporal changes in cells from the peritoneal cavity of septic mice and to identify potential biomarkers and therapeutic targets for this subset of sepsis patients. Results We conducted microarray analysis of the peritoneal cells of mice infected with a non-pathogenic strain of Escherichia coli. Differentially expressed genes were identified at two early (1 h, 2 h) and one late time point (18 h). A multiplexed bead array analysis was used to confirm protein expression for several cytokines which showed differential expression at different time points based on the microarray data. Gene Ontology based hypothesis testing identified a positive bias of differentially expressed genes associated with cellular development and cell death at 2 h and 18 h respectively. Most differentially expressed genes common to all 3 time points had an immune response related function, consistent with the observation that a few bacteria are still present at 18 h. Conclusions Transcriptional regulators like PLAGL2, EBF1, TCF7, KLF10 and SBNO2, previously not described in sepsis, are differentially expressed at early and late time points. Expression pattern for key biomarkers in this study is similar to that reported in human sepsis, indicating the suitability of this model for future studies of sepsis, and the observed differences in gene expression suggest species differences or differences in the response of blood leukocytes and peritoneal leukocytes

Lincoln University entomological expedition to Pitt Island

The expedition had two objectives: 1. To search for the Pitt Island longhorn beetle, Xylotoles costatus and determine its distribution, abundance and conservation status. 2. To undertake general entomological survey work, particularly in the orders Coleoptera, Diptera, Lepidoptera and Hymenoptera by using trapping methods not previously used on Pitt Island

Genetic Resources, Genome Mapping and Evolutionary Genomics of the Pig (Sus scrofa)

The pig, a representative of the artiodactyla clade, is one of the first animals domesticated, and has become an important agriculture animal as one of the major human nutritional sources of animal based protein. The pig is also a valuable biomedical model organism for human health. The pig's importance to human health and nutrition is reflected in the decision to sequence its genome (3X). As an animal species with its wild ancestors present in the world, the pig provides a unique opportunity for tracing mammalian evolutionary history and defining signatures of selection resulting from both domestication and natural selection. Completion of the pig genome sequencing project will have significant impacts on both agriculture and human health. Following the pig whole genome sequence drafts, along with large-scale polymorphism data, it will be possible to conduct genome sweeps using association mapping, and identify signatures of selection. Here, we provide a description of the pig genome sequencing project and perspectives on utilizing genomic technologies to exploit pig genome evolution and the molecular basis for phenotypic traits for improving pig production and health

Concentration and Bioactivity of Condensed Tannins and Total Phenolics of \u3cem\u3eLespedeza\u3c/em\u3e Species From a Germplasm Collection

Interest in ‘AU-Grazer’ sericea lespedeza (Lespedeza cuneata) as an anti-parasitic bioactive forage has been growing in the United States, but the concentration and bioactivity of tannins and other phenolics from additional accessions of L. cuneata, as well as other Lespedeza species, have not been evaluated. A study was completed to determine the concentration of extractable condensed tannins (ECT), total CT (TCT), total phenolics (TP), and protein-precipitable phenolics (PPP) of 32 accessions of L. cuneata and 16 additional Lespedeza species from a germplasm collection. The plants were established in small pots in a greenhouse and then transplanted into small field plots at the Fort Valley State University Agricultural Research Station in Georgia. Once established in the field, samples from each plot were collected, freeze-dried, and ground for analysis. The ECT and TCT for L. cuneata accessions averaged 6.6 ± 1.4% and 9.1 ± 1.8%, respectively, while TP were 114.8 ± 33.2 mg/g plant material and PPP averaged 81.5 ± 25.3 mg binding CT/g plant material. For other Lespedeza species, ECT ranged from 3.7 ± 1.3 (L. striate) to 8.8 ± 1.3 (L. frutescens) and TCT from 6.0 ± 0.5 (L. japonica) to 10.8 ± 1.3 (L. frutescens). Total phenolics ranged from 45.3 ± 24.0 (L. striate) to 185.8 ± 43.9 (L. virgata), and PPP from 22.1 ± 71 (L. tomentosa) to 89.0 ± 23.6 (L. virginica). All Lespedeza species evaluated in this study had relatively high levels of CT, with several species as high or higher in TP and PPP (bioactivity) than L. cuneata, suggesting potential increased use of these plants as nutraceutical forages for animals