A survey for large image-separation lensed quasars

The statistics of gravitationally lensed quasars with multiple images in the 0.1''-7'' range have been measured in various surveys. Little is known, however, about lensed-quasar statistics at larger image separations, which probe masses on the scale of galaxy clusters. We extend the results of the HST Snapshot Survey for Lensed Quasars to the 7''-50'' range for a sub-sample of 76 quasars that is free of known selection effects. Using a combination of multicolor photometry and spectroscopy, we show that none of the point sources in the entire field of view of the HST observations of these quasars are lensed images. Large-separation quasar lensing is therefore not common. We carry out a detailed calculation of the expected statistics of large-separation lensing for this quasar sample, incorporating realistic input for the mass profiles and mass function of galaxy clusters. We find that the observational null results are consistent with the expected effect of galaxy clusters, even if these have existed in their present form and number since z of about 2. The rarity of large-separation lensed quasars can rule out some extreme scenarios, e.g. that the mass-function of clusters has been severely underestimated, or that large mass concentrations that are not associated with galaxies (i.e. ``failed'' clusters) are common. The rareness of wide lensing also sets limits on the cosmological constant that are independent of limits derived from galaxy lensing. The lensing statistics of larger quasar samples can probe the structure, number, and evolution of clusters, as well as the geometry of space.Comment: LaTex, ApJ, submitte

Optical Continuum and Emission-Line Variability of Seyfert 1 Galaxies

We present the light curves obtained during an eight-year program of optical spectroscopic monitoring of nine Seyfert 1 galaxies: 3C 120, Akn 120, Mrk 79, Mrk 110, Mrk 335, Mrk 509, Mrk 590, Mrk 704, and Mrk 817. All objects show significant variability in both the continuum and emission-line fluxes. We use cross-correlation analysis to derive the sizes of the broad Hbeta-emitting regions based on emission-line time delays, or lags. We successfully measure time delays for eight of the nine sources, and find values ranging from about two weeks to a little over two months. Combining the measured lags and widths of the variable parts of the emission lines allows us to make virial mass estimates for the active nucleus in each galaxy. The virial masses are in the range 10^{7-8} solar masses.Comment: 24 pages, 16 figures. Accepted for publication in Ap

Central Masses and Broad-Line Region Sizes of Active Galactic Nuclei. II. A Homogeneous Analysis of a Large Reverberation-Mapping Database

We present improved black hole masses for 35 active galactic nuclei (AGNs) based on a complete and consistent reanalysis of broad emission-line reverberation-mapping data. From objects with multiple line measurements, we find that the highest precision measure of the virial product is obtained by using the cross-correlation function centroid (as opposed to the cross-correlation function peak) for the time delay and the line dispersion (as opposed to full width half maximum) for the line width and by measuring the line width in the variable part of the spectrum. Accurate line-width measurement depends critically on avoiding contaminating features, in particular the narrow components of the emission lines. We find that the precision (or random component of the error) of reverberation-based black hole mass measurements is typically around 30%, comparable to the precision attained in measurement of black hole masses in quiescent galaxies by gas or stellar dynamical methods. Based on results presented in a companion paper by Onken et al., we provide a zero-point calibration for the reverberation-based black hole mass scale by using the relationship between black hole mass and host-galaxy bulge velocity dispersion. The scatter around this relationship implies that the typical systematic uncertainties in reverberation-based black hole masses are smaller than a factor of three. We present a preliminary version of a mass-luminosity relationship that is much better defined than any previous attempt. Scatter about the mass-luminosity relationship for these AGNs appears to be real and could be correlated with either Eddington ratio or object inclination.Comment: 61 pages, including 8 Tables and 16 Figures. Accepted for publication in The Astrophysical Journa

A NWB-based dataset and processing pipeline of human single-neuron activity during a declarative memory task

A challenge for data sharing in systems neuroscience is the multitude of different data formats used. Neurodata Without Borders: Neurophysiology 2.0 (NWB:N) has emerged as a standardized data format for the storage of cellular-level data together with meta-data, stimulus information, and behavior. A key next step to facilitate NWB:N adoption is to provide easy to use processing pipelines to import/export data from/to NWB:N. Here, we present a NWB-formatted dataset of 1863 single neurons recorded from the medial temporal lobes of 59 human subjects undergoing intracranial monitoring while they performed a recognition memory task. We provide code to analyze and export/import stimuli, behavior, and electrophysiological recordings to/from NWB in both MATLAB and Python. The data files are NWB:N compliant, which affords interoperability between programming languages and operating systems. This combined data and code release is a case study for how to utilize NWB:N for human single-neuron recordings and enables easy re-use of this hard-to-obtain data for both teaching and research on the mechanisms of human memory

Minisuperspace Quantization of "Bubbling AdS" and Free Fermion Droplets

We quantize the space of 1/2 BPS configurations of Type IIB SUGRA found by Lin, Lunin and Maldacena (hep-th/0409174), directly in supergravity. We use the Crnkovic-Witten-Zuckerman covariant quantization method to write down the expression for the symplectic structure on this entire space of solutions. We find the symplectic form explicitly around AdS_5 x S^5 and obtain a U(1) Kac-Moody algebra, in precise agreement with the quantization of a system of N free fermions in a harmonic oscillator potential, as expected from AdS/CFT. As a cross check, we also perform the quantization around AdS_5 x S^5 by another method, using the known spectrum of physical perturbations around this background and find precise agreement with our previous calculation.Comment: 22 Pages + 2 Appendices, JHEP3; v3: explanation of factor 2 mismatch added, references reordered, published versio

The Correlation Between Galaxy HI Linewidths and K' Luminosities

The relationship between galaxy luminosities and rotation rates is studied with total luminosities in the K' band. Extinction problems are essentially eliminated at this band centered at 2.1 micron. A template luminosity-linewidth relation is derived based on 65 galaxies drawn from two magnitude-limited cluster samples. The zero-point is determined using 4 galaxies with accurately known distances. The calibration is applied to give the distance to the Pisces Cluster (60 Mpc) at a redshift in the CMB frame of 4771 km/s. The resultant value of the Hubble Constant is 81 km/s/Mpc. The largest sources of uncertainty arises from the small number of zero-point calibrators at this time at K' and present application to only one cluster.Comment: 13 pages including 5 figures and 2 tables. Accepted for publication in Astrophysical Journa

Supernovae in Low-Redshift Galaxy Clusters: Observations by the Wise Observatory Optical Transient Search (WOOTS)

We describe the Wise Observatory Optical Transient Search (WOOTS), a survey for supernovae (SNe) and other variable and transient objects in the fields of redshift 0.06-0.2 Abell galaxy clusters. We present the survey design and data-analysis procedures, and our object detection and follow-up strategies. We have obtained follow-up spectroscopy for all viable SN candidates, and present the resulting SN sample here. Out of the 12 SNe we have discovered, seven are associated with our target clusters while five are foreground or background field events. All but one of the SNe (a foreground field event) are Type Ia SNe. Our non-cluster SN sample is uniquely complete, since all SN candidates have been either spectroscopically confirmed or ruled out. This allows us to estimate that flux-limited surveys similar to WOOTS would be dominated (~80%) by SNe Ia. Our spectroscopic follow-up observations also elucidate the difficulty in distinguishing active galactic nuclei from SNe. In separate papers we use the WOOTS sample to derive the SN rate in clusters for this redshift range, and to measure the fraction of intergalactic cluster SNe. We also briefly report here on some quasars and asteroids discovered by WOOTS.Comment: Submitted to ApJ. Comments welcom

Supertube domain-walls and elimination of closed time-like curves in string theory

We show that some novel physics of supertubes removes closed time-like curves from many supersymmetric spaces which naively suffer from this problem. The main claim is that supertubes naturally form domain-walls, so while analytical continuation of the metric would lead to closed time-like curves, across the domain-wall the metric is non-differentiable, and the closed time-like curves are eliminated. In the examples we study the metric inside the domain-wall is always of the G\"odel type, while outside the shell it looks like a localized rotating object, often a rotating black hole. Thus this mechanism prevents the appearance of closed time-like curves behind the horizons of certain rotating black holes.Comment: 22 pages, JHEP3 class. V2: Some corrections and clariffications, references added. V3: more corrections to formulas, results unchanged. V4: minor typos, as published in PR

Epigenetic Suppression of Transgenic T-cell Receptor Expression via Gamma-Retroviral Vector Methylation in Adoptive Cell Transfer Therapy

Transgenic T-cell receptor (TCR) adoptive cell therapies recognizing tumor antigens are associated with robust initial response rates, but frequent disease relapse. This usually occurs in the setting of poor long-term persistence of cells expressing the transgenic TCR, generated using murine stem cell virus (MSCV) y-retroviral vectors. Analysis of clinical transgenic adoptive cell therapy products in vivo revealed that despite strong persistence of the transgenic TCR DNA sequence over time, its expression was profoundly decreased over time at the RNA and protein levels. Patients with the greatest degrees of expression suppression displayed significant increases in DNA methylation over time within the MSCV promoter region, as well as progressive increases in DNA methylation within the entire MSCV vector over time. These increases in vector methylation occurred independently of its integration site within the host genomes. These results have significant implications for the design of future viral-vector gene engineered adoptive cell transfer therapies

OGLE-2003-BLG-262: Finite-Source Effects from a Point-Mass Lens

We analyze OGLE-2003-BLG-262, a relatively short, t_E=12.5+-0.1day, microlensing event generated by a point-mass lens transiting the face of a K giant source in the Galactic bulge. We use the resulting finite-source effects to measure the angular Einstein radius, theta_E=195+-17muas, and so constrain the lens mass to the full-width half-maximum interval 0.08 < M/M_sun < 0.54. The lens-source relative proper motion is mu_rel = 27+-2 km/s/kpc. Both values are typical of what is expected for lenses detected toward the bulge. Despite the short duration of the event, we detect marginal evidence for a "parallax asymmetry", but argue that this is more likely to be induced by acceleration of the source, a binary lens, or possibly by statistical fluctuations. Although OGLE-2003-BLG-262 is only the second published event to date in which the lens transits the source, such events will become more common with the new OGLE-III survey in place. We therefore give a detailed account of the analysis of this event to facilitate the study of future events of this type.Comment: 9 pages, 6 figures, accepted for publication in the Astrophysical Journa