Robert Owen: Social reformer

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Apollo mission D performance analysis of rendezvous charts

Performance analysis of rendezvous charts for Apollo 9 missio

Note and Comment

The Ownership of Sunken Logs; Combination Among Physicians to Fix Prices for Professional Services; The Issuance of Receivers\u27 Certificates to pay Interest, Etc.; The Federal Constitution is Not Violated by a State Law Compelling one Accused of Crime to Testify Against Himself; Transfer of Negotiable Instrument Without Endorsemen

Note and Comment

Waiver of the Statutory Protection to the confidential Relation of Physician and Patient; Inter-State Rendition; When a Public Officer Misappropriating Public Funds is Not an Embezzler; When a Discharged Teacher May Resort to the Courts

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Internal Revenue Tax on State Dispensaries Upheld; What is the Practice of Medicine?; Appeals from Decrees for Costs; The Hearst Election Contest; The Lapse of a Legacy to a Deceased Child; Unsightly Advertisements and Billboard

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American Bar Association Meeting; Disbarment or Suspension of Attorney; Is the Property Owner Negligent if He Fails to Exercise Reasonable Care to Prevent an Injury to An Infant Trespasser?; Liability of Water companies for Losses by Fire; Evidence in Deportation Proceedings Under the Act of congress of May 5th, 1892; Duty of a Bank to a Surety to Apply Funds of a Principal Debtor to Satisfy a Debt Due the Bank

Note and Comment

A Spurious Law Course; Railroad Taxation in Michigan and Wisconsin; Surgical Operation on Minor Without Consent of Parent; The Power of Municipal Corporations to Grant Exclusive Privileges; Inheritance Taxes and the Right to Transfer and Inherit Property; The Sovereign Power of a State to Prevent Election Frauds; Original Jurisdiction of Supreme Court in Election Cases

Healthy Parks Healthy People: Evaluating and Improving Park Service Efforts to Promote Tourists Health and Well-being Introduction

Both Parks Victoria, AUS and the United States National Park Service (USNPS) focus on promoting human health and well-being while sustaining environmental well-being. This has been fostered by the agencies through the “Healthy Parks Healthy People” program, in which Parks Victoria and the USNPS are global leaders as well as agency collaborators. Given global concerns regarding health and well-being (human and environmental) this movement is crucial. However, in order for parks and associated tourism providers to implement effective health strategies, we must understand what a “healthy park” is, how evidence is being promoted to existing and potential tourists, and what lessons can be learned from these agencies to facilitate these benefits globally in other settings. This research examines these questions across both agencies through content analyses, interviews, and assessments of tourism use trends. Results inform global park tourism planning and promotion efforts to improve social and ecological

Smash and Bash Cricket? Affective Technological Innovations in the Big Bash

Focusing on the Australian KFC T20 Big Bash League (BBL), this article explores the innovative televisual technologies that represent T20 cricket as an action packed 'smash and bash' spectacle. An array of innovative technologies is deployed to aesthetically and affectively re-present the BBL. Cameras and microphones are embedded within the field of play, operate in highly mobile and fluid ways, and are framed in close proximity to the action - particularly when placed on the players themselves. The BBL provides intersecting affective layers for viewer engagement built upon tools for analysis, sites of commodification, visual renditions of pseudo-player perspectives and an emphasis on fast-paced entertainment. By constructing degrees of sensory invigoration and vicarious involvement for both casual and invested viewers, these innovative technologies mobilise 'smash and bash' cricket as an affective televisual spectacle

Global alterations to the choroid plexus blood-CSF barrier in amyotrophic lateral sclerosis

© 2020 The Author(s). The choroid plexus (CP) is a highly vascularized structure located in the ventricles that forms the blood-CSF barrier (BCSFB) and separates the blood from the cerebrospinal fluid (CSF). In addition to its role as a physical barrier, the CP functions in CSF secretion, transport of nutrients into the central nervous system (CNS) and a gated point of entry of circulating immune cells into the CNS. Aging and neurodegeneration have been reported to affect CP morphology and function and increase protein leakage from blood to the CSF. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease associated with both upper and lower motor neuron loss, as well as altered proteomic and metabolomic signatures in the CSF. The role of the BCSFB and the CP in ALS is unknown. Here we describe a transcriptomic and ultrastructural analysis of BCSFB and CP alterations in human postmortem tissues from ALS and non-neurologic disease controls. ALS-CP exhibited widespread disruptions in tight junctional components of the CP epithelial layer and vascular integrity. In addition, we detected loss of pericytes around ALS blood vessels, accompanied by activation of platelet aggregation markers vWF and Fibrinogen, reminiscent of vascular injury. To investigate the immune component of ALS-CP, we conducted a comprehensive analysis of cytokines and chemokine panels in CP lysates and found a significant down-regulation of M-CSF and V-CAM1 in ALS, as well as up-regulation of VEGF-A protein. This phenotype was accompanied by an infiltration of MERTK positive macrophages into the parenchyma of the ALS-CP when compared to controls. Taken together, we demonstrate widespread structural and functional disruptions of the BCSFB in human ALS increasing our understanding of the disease pathology and identifying potential new targets for ALS therapeutic development