Current etiological structure of bacteremia at the intensive care units of Yekaterinburg

In this report we present the results of bacteriological analysis of blood samples taken from patients at the intensive care units of Yekaterinburg city hospitals in 2006 - 2010. Studies were done in “BACTEC” (Beckton Dickinson) and “Walk/Away'1 (Siemens Healthcare) bacteriological automated systems. Highly resistant to antibiotics nosocomial strains of S. aureus (50.44%), Enterococcus spp. (19.77%), coagulase negative Staphilococcus spp. (9.25%), K. pneumoniae (7.98%), A baumannii (7.22%), E.coli (4.69%), P. Aerugionosa (3.8%) were isolated from adult patients with sepsis. Vancomycin and Unezolid remain highly active against Staphilococcus spp. and Enterococcus spp. (100% of strains were sensitive). Carbapenems are still actual for the therapy of septic conditions caused by representatives of Enterobacteriaceae family (more than 99% of strains were sensitive). Isolates of P. aeruginosa and A. baumannii arise certain difficulties for the adequate choice of drugs because their sensitivity to antibiotics needs to be determined.В работе представлены результаты микробиологического исследования крови 4133 пациентов ОРИТ стационаров г. Екатеринбурга за 2006-201 Ог.г. Работа выполнена с использованием микробиологических анализаторов Bactec (Becton Dickinson, США) и Walk Away (Siemens,USA). Среди возбудителей сепсиса у взрослых пациентов преобладают штаммы высокорезистентной госпитальной флоры S. aureus (50,44%), Enterococcus spp. (19,77%), коагулазоотрицательные стафилококки (9,25%), К. pneumoniae (7,98%), A. baumannii (7,22%), E.coli (4,69%), P. aeruginosa (3,8%). Ванкомицин и линезолид сохраняют высокую антибактериальную активность в отношении стафилококков и энтерококков (100% чувствительных штаммов). Карбапенемы продолжают оставаться препаратами выбора при терапии сепсиса, вызванного энтеробактериями (более 99% чувствительных штаммов). Наибольшую сложность для клинициста представляют случаи выделения P. aeruginosa, A. baumannii, при которых для подбора адекватной терапии требуется определение антибиотикочувствительности

Micro-aerobic bacterial methane oxidation in the chemocline and anoxic water column of deep south-Alpine Lake Lugano (Switzerland)

We measured seasonal variations in the vertical distribution of methane concentration, methane oxidation rates, and lipid biomarkers in the northern basin of Lake Lugano. Methane consumption below the oxic–anoxic interface co-occurred with concentration maxima of 13C-depleted C16 fatty acid biomarkers (with d13C values as low as 270%) in the anoxic water column, as well as characteristic d13CCH4 profiles. We argue that the conspicuous methane concentration gradients are primarily driven by (micro-)aerobic methane oxidation (MOx) below the chemocline. We measured a strong MOx potential throughout the anoxic water column, while MOx rates at in situ O2 concentration . 10 nmol L21 were undetectable. Similarly, we found MOx-related biomarkers and gene sequences encoding the particulate methane monooxygenase in the anoxic, but not the oxic, water. The mechanism of (episodic) oxygen supply sustaining the MOx community in anoxic waters is still uncertain. Our results indicate that a bacterial methanotrophic community is responsible for the methane consumption in Lake Lugano, without detectable contribution from archaeal methanotrophs. Bacterial populations that accumulated both at the suboxic–anoxic interface and in the deeper anoxic hypolimnion, where maximum potential MOx rates were observed throughout the year (1.5–2.5 mmol L21 d21) were mainly related to Methylobacter sp. Close relatives are found in lacustrine environments throughout the world, and their potential to thrive under micro- and anoxic conditions in Lake Lugano may imply that micro-aerobic methane oxidation is important in methane cycling and competition for methane and oxygen in stratified lakes worldwide

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