k-String tensions and their large-N dependence

We consider whether the 1/N corrections to k-string tensions must begin at order 1/N^2, as in the Sine Law, or whether odd powers of 1/N, as in Casimir Scaling, are also acceptable. The issue is important because different models of confinement differ in their predictions for the representation-dependence of k-string tensions, and corrections involving odd powers of 1/N would seem to be ruled out by the large-N expansion. We show, however, that k-string tensions may, in fact, have leading 1/N corrections, and consistency with the large-N expansion, in the open string sector, is achieved by an exact pairwise cancellation among terms involving odd powers of 1/N in particular combinations of Wilson loops. It is shown how these cancellations come about in a concrete example, namely, strong coupling lattice gauge theory with the heat-kernel action, in which k-string tensions follow the Casimir scaling rule.Comment: Talk presented at the XXIX International Symposium on Lattice Field Theory - Lattice 2011, July 10-16, 2011, Squaw Valley, Lake Tahoe, Californi

k-String tensions and the 1/N expansion

We address the question of whether the large-N expansion in pure SU(N) gauge theories requires that k-string tensions must have a power series expansion in 1/N^2, as in the sine law, or whether 1/N contributions are also allowable, as in Casimir scaling. We find that k-string tensions may, in fact, have 1/N corrections, and consistency with the large-N expansion in the open-string sector depends crucially on an exact cancellation, which we will prove, among terms involving odd powers of 1/N in particular combinations of Wilson loops. It is shown how these cancellations are fulfilled, and consistency with the large-N expansion achieved, in a concrete example, namely, strong-coupling lattice gauge theory with the heat-kernel action. This is a model which has both a 1/N^2 expansion and Casimir scaling of the k-string tensions. Analysis of the closed string channel in this model confirms our conclusions, and provides further insights into the large-N dependence of energy eigenstates and eigenvalues.Comment: RevTeX4, 21 pages. Typos corrected, references added, some discussions expanded; conclusions unchanged. Version to appear on PR

Quenched mesonic spectrum at large N

We compute the masses of the $\pi$ and of the $\rho$ mesons in the quenched approximation on a lattice with fixed lattice spacing $a \simeq 0.145 \ \mathrm{fm}$for SU($N$) gauge theory with$N = 2,3,4,6$. We find that a simple linear expression in$1/N^2$correctly captures the features of the lowest-lying meson states at those values of$N$. This enables us to extrapolate to$N = \infty$the behaviour of$m_{\pi}$as a function of the quark mass and of$m_{\rho}$as a function of$m_{\pi}$. Our results for the latter agree within 5% with recent predictions obtained in the AdS/CFT framework.Comment: Reference added; typos corrected; version to appear on JHE

Conformality in many-flavour lattice QCD at strong coupling

It is widely believed that chiral symmetry is spontaneously broken at zero temperature in the strong coupling limit of staggered fermions, for any number of colors and flavors. Using Monte Carlo simulations, we show that this conventional wisdom, based on a mean-field analysis, is wrong. For sufficiently many fundamental flavors, chiral symmetry is restored via a bulk, first-order transition. This chirally symmetric phase appears to be analytically connected with the expected conformal window of many-flavor continuum QCD. We perform simulations in the chirally symmetric phase at zero quark mass for various system sizes L, and measure the torelon mass, the Dirac spectrum and the hadron spectrum. All masses go to zero with 1/L. L is hence the only infrared length scale. Thus, the strong-coupling chirally restored phase appears as a convenient laboratory to study IR-conformality. Finally, we present a conjecture for the phase diagram of lattice QCD as a function of the bare coupling and the number of quark flavors.Comment: 15 pages, 12 figures. Notation clarified, discussion expanded, to appear in JHE

A persistent neutrophil-associated immune signature characterizes post-COVID-19 pulmonary sequelae.

Interstitial lung disease and associated fibrosis occur in a proportion of individuals who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection through unknown mechanisms. We studied individuals with severe coronavirus disease 2019 (COVID-19) after recovery from acute illness. Individuals with evidence of interstitial lung changes at 3 to 6 months after recovery had an up-regulated neutrophil-associated immune signature including increased chemokines, proteases, and markers of neutrophil extracellular traps that were detectable in the blood. Similar pathways were enriched in the upper airway with a concomitant increase in antiviral type I interferon signaling. Interaction analysis of the peripheral phosphoproteome identified enriched kinases critical for neutrophil inflammatory pathways. Evaluation of these individuals at 12 months after recovery indicated that a subset of the individuals had not yet achieved full normalization of radiological and functional changes. These data provide insight into mechanisms driving development of pulmonary sequelae during and after COVID-19 and provide a rational basis for development of targeted approaches to prevent long-term complications

Multiphase phenomena in Diesel fuel injection systems

Fuel Injection Equipment (FIE) are an integral component of modern Internal Combustion Engines (ICE), since they play a crucial role in the fuel atomization process and in the formation of a fuel/air combustible mixture, consequently affecting efficiency and pollutant formation. Advancements and improvements of FIE systems are determined by the complexity of the physical mechanisms taking place; the spatial scales are in the order of millimetres, flow may become locally highly supersonic, leading to very small temporal scales of microseconds or less. The operation of these devices is highly unsteady, involving moving geometries such as needle valves. Additionally, extreme pressure changes imply that many assumptions of traditional fluid mechanics, such as incompressibility, are no longer valid. Furthermore, the description of the fuel properties becomes an issue, since fuel databases are scarce or limited to pure components, whereas actual fuels are commonly hydrocarbon mixtures. Last but not least, complicated phenomena such as phase change or transition from subcritical to transcritical/supercritical state of matter further pose complications in the understanding of the operation of these devices

Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma:A MASK-air study

Introduction Adherence to controller medication is a major problem in asthma management, being difficult to assess and tackle. mHealth apps can be used to assess adherence. We aimed to assess the adherence to inhaled corticosteroids+long-acting β2-agonists (ICS+LABA) in users of the MASK-air® app, comparing the adherence to ICS+formoterol (ICS+F) with that to ICS+other LABA. Materials and methods We analysed complete weeks of MASK-air® data (2015-2022; 27 countries) from patients with self-reported asthma and ICS+LABA use. We compared patients reporting ICS+F versus ICS+other LABA on adherence levels, symptoms and symptom-medication scores. We built regression models to assess whether adherence to ICS+LABA was associated with asthma control or short-acting beta-agonist (SABA) use. Sensitivity analyses were performed considering the weeks with no more than one missing day. Results In 2598 ICS+LABA users, 621 (23.9%) reported 4824 complete weeks and 866 (33.3%) reported weeks with at most one missing day. Higher adherence (use of medication ≥80% of weekly days) was observed for ICS+other LABA (75.1%) when compared to ICS+F (59.3%), despite both groups displaying similar asthma control and work productivity. The ICS+other LABA group was associated with more days of SABA use than the ICS+F group (median=71.4% versus 57.1% days). Each additional weekly day of ICS+F use was associated with a 4.1% less risk in weekly SABA use (95%CI=-6.5;-1.6%;p=0.001). For ICS+other LABA, the percentage was 8.2 (95%CI=-11.6;-5.0%;p<0.001). Conclusions In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control

Digital Health Europe (DHE) Twinning on Severe Asthma—Kick-off Meeting Report

info:eu-repo/semantics/publishedVersio

Comparison of Rhinitis Treatments Using MASK-air ® Data and Considering the Minimal Important Difference

Background: Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., "real-world data"). We aimed to compare AR pharmacological treatments on (i) daily symptoms, (ii) frequency of use in co-medication, (iii) visual analogue scales (VASs) on allergy symptom control considering the minimal important difference (MID) and (iv) the effect of AIT. Methods: We assessed the MASK-air® app data (May 2015-December 2020) by users self-reporting AR (16-90 years). We compared eight AR medication schemes on reported VAS of allergy symptoms, clustering data by the patient and controlling for confounding factors. We compared (i) allergy symptoms between patients with and without AIT and (ii) different drug classes used in co-medication. Results: We analysed 269,837 days from 10,860 users. Most days (52.7%) involved medication use. Median VAS levels were significantly higher in co-medication than in monotherapy (including the fixed combination azelastine-fluticasone) schemes. In adjusted models, azelastine-fluticasone was associated with lower average VAS global allergy symptoms than all other medication schemes, while the contrary was observed for oral corticosteroids. AIT was associated with a decrease in allergy symptoms in some medication schemes. A difference larger than the MID compared to no treatment was observed for oral steroids. Azelastine-fluticasone was the drug class with the lowest chance of being used in co-medication (adjusted OR = 0.75; 95% CI = 0.71-0.80). Conclusion: Median VAS levels were higher in co-medication than in monotherapy. Patients with more severe symptoms report a higher treatment, which is currently not reflected in guidelines.info:eu-repo/semantics/publishedVersio