Field Quality Measurements in a Single-Aperture 11 T Nb3Sn Demonstrator Dipole for LHC Upgrades

n/

Field quality of quadrupole R&D models for the LHC IR

Superconducting quadrupole magnets operating in superfluid helium at 1.9 K, with 70 mm bore and nominal field gradient of 205 T/m at collision optics, are being developed by the US LHC Accelerator Project for the Interaction Regions of the Large Hadron Collider (LHC). A magnet model program to validate and optimize the design is underway. This paper reports results of field quality measurements of four model magnets. (3 refs)

Quench performance of Fermilab high gradient quadrupole short models for the LHC Interaction Regions

Fermilab and LBNL are in the midst of superconducting magnet R&D program to test and optimize the design of quadrupoles to be used in the LHC Interaction Region inner triplets. The magnets are required to deliver a 215 T/m gradient across a 70 mm aperture. Five quadrupole short models have been fabricated and four of them have been tested. This paper describes the last model design details and reports the results of the magnet quench performance study. (5 refs)

Telomere disruption results in non-random formation of de novo dicentric chromosomes involving acrocentric human chromosomes

Copyright: © 2010 Stimpson et al.Genome rearrangement often produces chromosomes with two centromeres (dicentrics) that are inherently unstable because of bridge formation and breakage during cell division. However, mammalian dicentrics, and particularly those in humans, can be quite stable, usually because one centromere is functionally silenced. Molecular mechanisms of centromere inactivation are poorly understood since there are few systems to experimentally create dicentric human chromosomes. Here, we describe a human cell culture model that enriches for de novo dicentrics. We demonstrate that transient disruption of human telomere structure non-randomly produces dicentric fusions involving acrocentric chromosomes. The induced dicentrics vary in structure near fusion breakpoints and like naturally-occurring dicentrics, exhibit various inter-centromeric distances. Many functional dicentrics persist for months after formation. Even those with distantly spaced centromeres remain functionally dicentric for 20 cell generations. Other dicentrics within the population reflect centromere inactivation. In some cases, centromere inactivation occurs by an apparently epigenetic mechanism. In other dicentrics, the size of the alpha-satellite DNA array associated with CENP-A is reduced compared to the same array before dicentric formation. Extrachromosomal fragments that contained CENP-A often appear in the same cells as dicentrics. Some of these fragments are derived from the same alpha-satellite DNA array as inactivated centromeres. Our results indicate that dicentric human chromosomes undergo alternative fates after formation. Many retain two active centromeres and are stable through multiple cell divisions. Others undergo centromere inactivation. This event occurs within a broad temporal window and can involve deletion of chromatin that marks the locus as a site for CENP-A maintenance/replenishment.This work was supported by the Tumorzentrum Heidelberg/Mannheim grant (D.10026941)and by March of Dimes Research Foundation grant #1-FY06-377 and NIH R01 GM069514

First observation of cyclotron radiation from MeV-scale epm{\rm e}^{pm} following nuclear beta decay

We present an apparatus for detection of cyclotron radiation that allows a frequency-based beta energy determination in the 5 keV to 5 MeV range, characteristic of nuclear beta decays. The cyclotron frequency of the radiating beta particles in a magnetic field is used to determine the beta energy precisely. Our work establishes the foundation to apply the cyclotron radiation emission spectroscopy (CRES) technique, developed by the Project 8 collaboration, far beyond the 18-keV tritium endpoint region. We report initial measurements of beta^-s from 6He and beta^+s from 19Ne decays to demonstrate the broadband response of our detection system and assess potential systematic uncertainties for beta spectroscopy over the full (MeV) energy range. This work is an important benchmark for the practical application of the CRES technique to a variety of nuclei, in particular, opening its reach to searches for evidence of new physics beyond the TeV scale via precision beta-decay measurements

Cyclotron radiation emission spectroscopy signal classification with machine learning in project 8

The cyclotron radiation emission spectroscopy (CRES) technique pioneered by Project 8measures electromagnetic radiation fromindividual electrons gyrating in a backgroundmagnetic field to construct a highly precise energy spectrumfor beta decay studies and other applications. The detector,magnetic trap geometry and electron dynamics give rise to amultitude of complex electron signal structures which carry information about distinguishing physical traits.Withmachine learningmodels, we develop a scheme based on these traits to analyze and classifyCRES signals. Proper understanding and use of these traits will be instrumental to improve cyclotron frequency reconstruction and boost the potential of Project 8 to achieveworld-leading sensitivity on the tritiumendpointmeasurement in the future

Locust: C++ software for simulation of RF detection

The Locust simulation package is a newC++software tool developed to simulate the measurement of time-varying electromagnetic fields using RF detection techniques. Modularity and flexibility allow for arbitrary input signals, while concurrently supporting tight integration with physics-based simulations as input. External signals driven by the Kassiopeia particle tracking package are discussed, demonstrating conditional feedback between Locust and Kassiopeia during software execution. An application of the simulation to the Project8 experiment is described