Measurement of the interaction strength in a Bose-Fermi mixture with 87Rb and 40K

A quantum degenerate, dilute gas mixture of bosonic and fermionic atoms was produced using 87Rb and 40K. The onset of degeneracy was confirmed by observing the spatial distribution of the gases after time-of-flight expansion. Further, the magnitude of the interspecies scattering length between the doubly spin polarized states of 87Rb and 40K, |a_RbK|, was determined from cross-dimensional thermal relaxation. The uncertainty in this collision measurement was greatly reduced by taking the ratio of interspecies and intraspecies relaxation rates, yielding |a_RbK| = 250 +/- 30 a_0, which is a lower value than what was reported in [M. Modugno et al., Phys. Rev. A 68, 043626 (2003)]. Using the value for |a_RbK| reported here, current T=0 theory would predict a threshold for mechanical instability that is inconsistent with the experimentally observed onset for sudden loss of fermions in [G. Modugno et al., Science 297, 2240 (2002)].Comment: RevTeX4 + 4 eps figures; Replaced with published versio

Observation of Heteronuclear Feshbach Resonances in a Bose-Fermi Mixture

Three magnetic-field induced heteronuclear Feshbach resonances were identified in collisions between bosonic 87Rb and fermionic 40K atoms in their absolute ground states. Strong inelastic loss from an optically trapped mixture was observed at the resonance positions of 492, 512, and 543 +/- 2 G. The magnetic-field locations of these resonances place a tight constraint on the triplet and singlet cross-species scattering lengths, yielding -281 +/- 15 Bohr and -54 +/- 12 Bohr, respectively. The width of the loss feature at 543 G is 3.7 +/- 1.5 G wide; this broad Feshbach resonance should enable experimental control of the interspecies interactions.Comment: revtex4 + 5 EPS figure

Known allosteric proteins have central roles in genetic disease

Allostery is a form of protein regulation, where ligands that bind sites located apart from the active site can modify the activity of the protein. The molecular mechanisms of allostery have been extensively studied, because allosteric sites are less conserved than active sites, and drugs targeting them are more specific than drugs binding the active sites. Here we quantify the importance of allostery in genetic disease. We show that 1) known allosteric proteins are central in disease networks, and contribute to genetic disease and comorbidities much more than non-allosteric proteins, in many major disease types like hematopoietic diseases, cardiovascular diseases, cancers, diabetes, or diseases of the central nervous system. 2) variants from cancer genome-wide association studies are enriched near allosteric proteins, indicating their importance to polygenic traits; and 3) the importance of allosteric proteins in disease is due, at least partly, to their central positions in protein-protein interaction networks, and probably not due to their dynamical properties

Ideal Quantum Gases in D-dimensional Space and Power-law Potentials

We investigate ideal quantum gases in D-dimensional space and confined in a generic external potential by using the semiclassical approximation. In particular, we derive density of states, density profiles and critical temperatures for Fermions and Bosons trapped in isotropic power-law potentials. Form such results, one can easily obtain those of quantum gases in a rigid box and in a harmonic trap. Finally, we show that the Bose-Einstein condensation can set up in a confining power-law potential if and only if ${D/2}+{D/n}>1$, where $D$ is the space dimension and $n$ is the power-law exponent.Comment: 18 pages, Latex, to be published in Journal of Mathematical Physic

Developing and implementing an integrated delirium prevention system of care:a theory driven, participatory research study

Background: Delirium is a common complication for older people in hospital. Evidence suggests that delirium incidence in hospital may be reduced by about a third through a multi-component intervention targeted at known modifiable risk factors. We describe the research design and conceptual framework underpinning it that informed the development of a novel delirium prevention system of care for acute hospital wards. Particular focus of the study was on developing an implementation process aimed at embedding practice change within routine care delivery. Methods: We adopted a participatory action research approach involving staff, volunteers, and patient and carer representatives in three northern NHS Trusts in England. We employed Normalization Process Theory to explore knowledge and ward practices on delirium and delirium prevention. We established a Development Team in each Trust comprising senior and frontline staff from selected wards, and others with a potential role or interest in delirium prevention. Data collection included facilitated workshops, relevant documents/records, qualitative one-to-one interviews and focus groups with multiple stakeholders and observation of ward practices. We used grounded theory strategies in analysing and synthesising data. Results: Awareness of delirium was variable among staff with no attention on delirium prevention at any level; delirium prevention was typically neither understood nor perceived as meaningful. The busy, chaotic and challenging ward life rhythm focused primarily on diagnostics, clinical observations and treatment. Ward practices pertinent to delirium prevention were undertaken inconsistently. Staff welcomed the possibility of volunteers being engaged in delirium prevention work, but existing systems for volunteer support were viewed as a barrier. Our evolving conception of an integrated model of delirium prevention presented major implementation challenges flowing from minimal understanding of delirium prevention and securing engagement of volunteers alongside practice change. The resulting Prevention of Delirium (POD) Programme combines a multi-component delirium prevention and implementation process, incorporating systems and mechanisms to introduce and embed delirium prevention into routine ward practices. Conclusions: Although our substantive interest was in delirium prevention, the conceptual and methodological strategies pursued have implications for implementing and sustaining practice and service improvements more broadly

Cerenkov-like radiation in a binary Schr{\"o}dinger flow past an obstacle

We consider the dynamics of two coupled miscible Bose-Einstein condensates, when an obstacle is dragged through them. The existence of two different speeds of sound provides the possibility for three dynamical regimes: when both components are subcritical, we do not observe nucleation of coherent structures; when both components are supercritical they both form dark solitons in one dimension (1D) and vortices or rotating vortex dipoles in two dimensions (2D); in the intermediate regime, we observe the nucleation of a structure in the form of a dark-antidark soliton in 1D; subcritical component; the 2D analog of such a structure, a vortex-lump, is also observed.Comment: 4 pages, 4 figures, submitted to Phys Rev

Enhancing capacity of coherent optical information storage and transfer in a Bose-Einstein condensate

Coherent optical information storage capacity of an atomic Bose-Einstein condensate is examined. Theory of slow light propagation in atomic clouds is generalized to short pulse regime by taking into account group velocity dispersion. It is shown that the number of stored pulses in the condensate can be optimized for a particular coupling laser power, temperature and interatomic interaction strength. Analytical results are derived for semi-ideal model of the condensate using effective uniform density zone approximation. Detailed numerical simulations are also performed. It is found that axial density profile of the condensate protects the pulse against the group velocity dispersion. Furthermore, taking into account finite radial size of the condensate, multi-mode light propagation in atomic Bose-Einstein condensate is investigated. The number of modes that can be supported by a condensate is found. Single mode condition is determined as a function of experimentally accessible parameters including trap size, temperature, condensate number density and scattering length. Quantum coherent atom-light interaction schemes are proposed for enhancing multi-mode light propagation effects.Comment: 12pages. Laser Physics, in pres

Generating entangled atom-photon pairs from Bose-Einstein condensates

We propose using spontaneous Raman scattering from an optically driven Bose-Einstein condensate as a source of atom-photon pairs whose internal states are maximally entangled. Generating entanglement between a particle which is easily transmitted (the photon) and one which is easily trapped and coherently manipulated (an ultracold atom) will prove useful for a variety of quantum-information related applications. We analyze the type of entangled states generated by spontaneous Raman scattering and construct a geometry which results in maximum entanglement

Vortices in a Bose-Einstein condensate confined by an optical lattice

We investigate the dynamics of vortices in repulsive Bose-Einstein condensates in the presence of an optical lattice (OL) and a parabolic magnetic trap. The dynamics is sensitive to the phase of the OL potential relative to the magnetic trap, and depends less on the OL strength. For the cosinusoidal OL potential, a local minimum is generated at the trap's center, creating a stable equilibrium for the vortex, while in the case of the sinusoidal potential, the vortex is expelled from the center, demonstrating spiral motion. Cases where the vortex is created far from the trap's center are also studied, revealing slow outward-spiraling drift. Numerical results are explained in an analytical form by means of a variational approximation. Finally, motivated by a discrete model (which is tantamount to the case of the strong OL lattice), we present a novel type of vortex consisting of two pairs of anti-phase solitons.Comment: 10 pages, 6 figure

Suppression and enhancement of impurity scattering in a Bose-Einstein condensate

Impurity atoms propagating at variable velocities through a trapped Bose-Einstein condensate were produced using a stimulated Raman transition. The redistribution of momentum by collisions between the impurity atoms and the stationary condensate was observed in a time-of-flight analysis. The collisional cross section was dramatically reduced when the velocity of the impurities was reduced below the speed of sound of the condensate, in agreement with the Landau criterion for superfluidity. For large numbers of impurity atoms, we observed an enhancement of atomic collisions due to bosonic stimulation. This enhancement is analogous to optical superradiance.Comment: 4 pages, 4 figure