PAMELA's cosmic positron from decaying LSP in SO(10) SUSY GUT

We propose two viable scenarios explaining the recent observations on cosmic positron excess. In both scenarios, the present relic density in the Universe is assumed to be still supported by thermally produced WIMP or LSP (\chi). One of the scenarios is based on two dark matter (DM) components (\chi,X) scenario, and the other is on SO(10) SUSY GUT. In the two DM components scenario, extremely small amount of non-thermally produced meta-stable DM component [O(10^{-10}) < n_X /n_\chi] explains the cosmic positron excess. In the SO(10) model, extremely small R-parity violation for LSP decay to e^\pm is naturally achieved with a non-zero VEV of the superpartner of one right-handed neutrino (\tilde{\nu}^c) and a global symmetry.Comment: 6 pages, Talks presented in PASCOS, SUSY, and COSMO/CosPA in 201

On magnetic leaf-wise intersections

In this article we introduce the notion of a magnetic leaf-wise intersection point which is a generalization of the leaf-wise intersection point with magnetic effects. We also prove the existence of magnetic leaf-wise intersection points under certain topological assumptions.Comment: 43 page

Radion Dynamics and Phenomenology in the Linear Dilaton Model

We investigate the properties of the radion in the 5D linear dilaton model arising from Little String Theory. A Goldberger-Wise type mechanism is used to stabilise a large interbrane distance, with the dilaton now playing the role of the stabilising field. We consider the coupled fluctuations of the metric and dilaton fields and identify the physical scalar modes of the system. The wavefunctions and masses of the radion and Kaluza-Klein modes are calculated, giving a radion mass of order the curvature scale. As a result of the direct coupling between the dilaton and Standard Model fields, the radion couples to the SM Lagrangian, in addition to the trace of the energy-momentum tensor. The effect of these additional interaction terms on the radion decay modes is investigated, with a notable increase in the branching fraction to photons. We also consider the effects of a non-minimal Higgs coupling to gravity, which introduces a mixing between the Higgs and radion modes. Finally, we calculate the production cross section of the radion at the LHC and use the current Higgs searches to place constraints on the parameter space.Comment: 28 pages, 7 figures; v2: error in radion-gauge boson Feynman rules corrected, version published in JHE

Key distillation from quantum channels using two-way communication protocols

We provide a general formalism to characterize the cryptographic properties of quantum channels in the realistic scenario where the two honest parties employ prepare and measure protocols and the known two-way communication reconciliation techniques. We obtain a necessary and sufficient condition to distill a secret key using this type of schemes for Pauli qubit channels and generalized Pauli channels in higher dimension. Our results can be applied to standard protocols such as BB84 or six-state, giving a critical error rate of 20% and 27.6%, respectively. We explore several possibilities to enlarge these bounds, without any improvement. These results suggest that there may exist weakly entangling channels useless for key distribution using prepare and measure schemes.Comment: 21 page

DNA end resection by Dna2–Sgs1–RPA and its stimulation by Top3–Rmi1 and Mre11–Rad50–Xrs2

The repair of DNA double-strand breaks (DSBs) by homologous recombination requires processing of broken ends. For repair to start, the DSB must first be resected to generate a 3′-single-stranded DNA (ssDNA) overhang, which becomes a substrate for the DNA strand exchange protein, Rad51 (ref. 1). Genetic studies have implicated a multitude of proteins in the process, including helicases, nucleases and topoisomerases. Here we biochemically reconstitute elements of the resection process and reveal that it requires the nuclease Dna2, the RecQ-family helicase Sgs1 and the ssDNA-binding protein replication protein-A (RPA). We establish that Dna2, Sgs1 and RPA constitute a minimal protein complex capable of DNA resection in vitro. Sgs1 helicase unwinds the DNA to produce an intermediate that is digested by Dna2, and RPA stimulates DNA unwinding by Sgs1 in a species-specific manner. Interestingly, RPA is also required both to direct Dna2 nucleolytic activity to the 5′-terminated strand of the DNA break and to inhibit 3′ to 5′ degradation by Dna2, actions that generate and protect the 3′-ssDNA overhang, respectively. In addition to this core machinery, we establish that both the topoisomerase 3 (Top3) and Rmi1 complex and the Mre11–Rad50–Xrs2 complex (MRX) have important roles as stimulatory components. Stimulation of end resection by the Top3–Rmi1 heterodimer and the MRX proteins is by complex formation with Sgs1 (refs 5, 6), which unexpectedly stimulates DNA unwinding. We suggest that Top3–Rmi1 and MRX are important for recruitment of the Sgs1–Dna2 complex to DSBs. Our experiments provide a mechanistic framework for understanding the initial steps of recombinational DNA repair in eukaryotes

Graduate HRD Programs in South Korea

The Problem To address national issues associated with societal development, many countries are recognizing the need to educate individuals who will lead developmental initiatives. While many previous studies have been conducted to examine how and what content of human resource development (HRD) has been taught in Western countries, similar research efforts have been rarely conducted in Asian countries such as South Korea. The lack of comparative study creates a research gap in understanding how HRD programs have been designed and implemented in different countries.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Four-Dimensional Effective Supergravity and Soft Terms in M-Theory

We provide a simple macroscopic analysis of the four-dimensional effective supergravity of the Ho\v{r}ava-Witten M-theory which is expanded in powers of $\kappa^{2/3}/\rho V^{1/3}$ and $\kappa^{2/3}\rho/V^{2/3}$ where $\kappa^2$, $V$ and $\rho$ denote the eleven-dimensional gravitational coupling, the Calabi-Yau volume and the eleventh length respectively. Possible higher order terms in the K\"ahler potential are identified and matched with the heterotic string corrections. In the context of this M-theory expansion, we analyze the soft supersymmetry-breaking terms under the assumption that supersymmetry is spontaneously broken by the auxiliary components of the bulk moduli superfields. It is examined how the pattern of soft terms changes when one moves from the weakly coupled heterotic string limit to the M-theory limit.Comment: Latex, 23 pages, 3 figures. References are added and the discussion of the M-theory expansion parameters is enlarge

Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort

BACKGROUND: The metabolic syndrome (MetS) may contribute to the increased cardiovascular risk in systemic lupus erythematosus (SLE). We examined the association between MetS and disease activity, disease phenotype and corticosteroid exposure over time in patients with SLE. METHODS: Recently diagnosed (\u3c15 \u3emonths) patients with SLE from 30 centres across 11 countries were enrolled into the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort from 2000 onwards. Baseline and annual assessments recorded clinical, laboratory and therapeutic data. A longitudinal analysis of factors associated with MetS in the first 2 years of follow-up was performed using random effects logistic regression. RESULTS: We studied 1150 patients with a mean (SD) age of 34.9 (13.6) years and disease duration at enrolment of 24.2 (18.0) weeks. In those with complete data, MetS prevalence was 38.2% at enrolment, 34.8% at year 1 and 35.4% at year 2. In a multivariable random effects model that included data from all visits, prior MetS status, baseline renal disease, SLICC Damage Index \u3e1, higher disease activity, increasing age and Hispanic or Black African race/ethnicity were independently associated with MetS over the first 2 years of follow-up in the cohort. CONCLUSIONS: MetS is a persistent phenotype in a significant proportion of patients with SLE. Renal lupus, active inflammatory disease and damage are SLE-related factors that drive MetS development while antimalarial agents appear to be protective from early in the disease course