Covishield vaccine experience in a health care setting

Background: SARS-CoV-2 pandemic has affected the whole world and India is one among the most affected countries. Vaccination is the most important tool to halt this pandemic and vaccine hesitancy unfortunately derails vaccination drive. Vaccine hesitancy among people is mainly due to concerns about vaccine safety! This study was done to assess adverse effects of Covishield vaccine among health care workers in a single health care organization.Methods: All the vaccine recipients were requested to answer a questionnaire with demographic details and various side effects following both the doses of Covishield vaccination.Results: About 665 employees responded to the questionnaire and the most common adverse reaction following Covishield vaccine was injection site pain, which was reported by 63% of vaccinees after first dose of vaccine.Conclusions: Covishield vaccine is relatively safe and incidence of major adverse events are rare following vaccination

DATACRACY IN BUILDING MELIKAN VILLAGE, EFFORTS OUT OF EXTREME POVERTY

As one of the villages that fall into the category of extreme poor, Melikan Village in Klaten Regency must start using data in planning development. This study aims to explore how the Melikan Village Government utilizes the SDG's Village data in preparing development plans. The method used in this research is qualitative with an interpretative approach. The informants selected were the Village Head, Village Secretary, Heads of Affairs and Section Heads, BPD Chairs and Members, youth leaders and community leaders. The results showed that the Melikan Village Government did not know from where the data sources used by the supra-village government in determining the village poverty level came from. Even the village head questioned the source of the data used to determine Melikan as a village with an extreme category. The real conditions in Melikan Village do not show any indicators of extreme poverty. In development planning, Melikan Village has not been based on data because it prioritizes the village deliberation process. Melikan Village conducts the SDG's Village data collection process which can be used as a basis for future development planning by prioritizing the first goal of SDG's Desa, namely a village without poverty

The International Natural Product Sciences Taskforce (INPST) and the power of Twitter networking exemplified through #INPST hashtag analysis

Background: The development of digital technologies and the evolution of open innovation approaches have enabled the creation of diverse virtual organizations and enterprises coordinating their activities primarily online. The open innovation platform titled "International Natural Product Sciences Taskforce" (INPST) was established in 2018, to bring together in collaborative environment individuals and organizations interested in natural product scientific research, and to empower their interactions by using digital communication tools. Methods: In this work, we present a general overview of INPST activities and showcase the specific use of Twitter as a powerful networking tool that was used to host a one-week "2021 INPST Twitter Networking Event" (spanning from 31st May 2021 to 6th June 2021) based on the application of the Twitter hashtag #INPST. Results and Conclusion: The use of this hashtag during the networking event period was analyzed with Symplur Signals (https://www.symplur.com/), revealing a total of 6,036 tweets, shared by 686 users, which generated a total of 65,004,773 impressions (views of the respective tweets). This networking event's achieved high visibility and participation rate showcases a convincing example of how this social media platform can be used as a highly effective tool to host virtual Twitter-based international biomedical research events

Structural analyses of the crystalline rocks between Dirang and Tawang, West Kameng district, Arunachal Himalaya

In Kameng Valley of Arunachal Pradesh, the crystalline rocks of Se La Group of Higher Himalaya are thrust over the Lesser Himalayan rocks of Dirang Formation, Bomdila Group along the Main Central Thrust and exhibit well preserved structures on macro- to microscopic scales. Detailed analysis of structures reveals that the rocks of the area have suffered four phases of deformation D1, D2, D3 and D4. These structures have been grouped into (i) early structures (ii) structures related to progressive ductile thrusting and (iii) late structures. The early structures which developed before thrusting formed during D1 and D2 phases of deformation, synchronous to F1 and F2 phases of folding respectively. The structures related to progressive ductile shearing developed during D3 phase of deformation, when the emplacement of the crystalline rocks took place over the rocks of Dirang Formation along the Main Central Thrust. Different asymmetric structures/kinematic indicators developed during this ductile/brittle-ductile regime suggest top-to-SSW sense of movement of the crystalline rocks of the area. D4 is attributed to brittle deformation. Based on satellite data two new thrusts, i.e. Tawang and Se La thrusts have been identified parallel to Main Central Thrust, which are suggestive of imbricate thrusting. Strain analysis from the quartz grains of the gneissic rocks reveals constriction type of strain ellipsoid where k value is higher near the MCT, gradually decreases towards the north. Further, the dynamic analysis carried out on the mesoscopic ductile and brittle-ductile shear zones suggest a NNE-SSW horizontal compression corresponding to the direction of northward movement of Indian Plate

Xanes Study of Fluctuation of Iron Valence in FeW₁₋ₓNbₓO₄ Solid Solutions

K-absorption edge of iron in FeW1-xNbxxO4 with 0 \u3c x \u3c 1 solid solutions was measured with high resolution using synchrotron radiation. The edge and the white line are found to shift to higher energy with increasing Nb content due possibly to presence of Fe2+ and Fe3+. In addition, the white line develops a two peak structure with the second peak growing in intensity with increasing Nb content: a definite indication of valence fluctuation. After examining various interpretations, we conclude an IV state for iron as a consequence of configurational fluctuation in this series

Synthesis of (±)-Pisonivanone and Other Analogs as Potent Antituberculosis Agents

A new class of alkylated chalcones and flavanones was synthesised and screened for antituberculosis, antixoidant, and cytotoxic activities. The desired compounds were synthesised using methyl substituted 2-hydroxyacetophenone as a key intermediate. The acetophenone derivative having methyl substitution was prepared in turn from methtylated phloroglucinol by formylation (by Vilsmeier-Haack reaction), followed by reduction with Wolf-Kishnner approach, and finally acetylation was involved. Among 17 compounds, compound 5 and compound 4a inhibited M. tuberculosis at minimum inhibitory concentration (MIC) in the range between 25 μg/mL and 50 μg/mL. The remaining other 15 compounds also potently inhibited M. tuberculosis at MIC in range between 50 μg/mL and 100 μg/mL. Some of these compounds also showed moderate antioxidant and cytotoxic activities

Service Transformation as a Tool for Promoting Sustainable Rural Development in Central Java

The current developments in Information Technology (IT) should not only be utilized by the public and the private sectors but also by all parties effectively. The government must also be able to take advantage of these advances in many ways, such as in providing government services. The role of IT in managing government has now become an essential part of the society. This study examines the people's expectations in Melikan Village and focuses on using IT advances to create an independent village. The author then draws upon SDG theories to delineate the service transformation process. It is a qualitative study consisting of primary and secondary data. The data collection techniques used in this study include in-depth interviews, FGD, observations, and document analysis. The findings show that IT has become a vital need for the people in Melikan, but the village government fails to meet those expectations. The study suggests that the local government needs technological innovation to develop Melikan Village and add more personnel to help with government services

Metagenomics and metatranscriptomics suggest pathways of 3-chloroaniline degradation in wastewater reactors

Biological wastewater treatment systems are often affected by shifts in influent quality, including the input of toxic chemicals. Yet the mechanisms underlying the adaptation of activated sludge process performance are rarely studied in a controlled and replicated experimental setting, particularly when challenged with a sustained toxin input. Three replicate bench-scale bioreactors were subjected to a chemical disturbance in the form of 3-chloroaniline (3-CA) over 132 days, after an acclimation period of 58 days, while three control reactors received no 3-CA input. Ammonia oxidation was initially affected by 3-CA. Within three weeks of the experiment, microbial communities in all three treatment reactors adapted to biologically degrade 3-CA resulting in partial ammonia oxidation recovery. Combining process and microbial community data from amplicon sequencing with potential functions gleaned from assembled metagenomics and metatranscriptomics data, two putative degradation pathways for 3-CA were identified. The first pathway, determined from metagenomics data, involves a benzoate dioxygenase and subsequent meta-cleavage of the aromatic ring. The second, determined from intensive short-term sampling for gene expression data in tandem with 3-CA degradation, involves a phenol monooxygenase followed by ortho-cleavage of the aromatic ring. The relative abundances of amplicon sequence variants associated with the genera Gemmatimonas, OLB8, and Taibaiella correlated significantly with 3-CA degradation. Metagenome-assembled genome data also showed the genus OLB8 to be differentially enriched in treatment reactors, making it a strong candidate as 3-CA degrader. Using replicated reactors, this study has demonstrated the impact of a sustained stress on the activated sludge process. The unique and novel features of this study include the identification of putative pathways and potential degraders of 3-CA using long-term and short-term sampling in tandem with multiple methods in a controlled and replicated experiment.Ministry of Education (MOE)National Research Foundation (NRF)This work was funded by the Singapore Ministry of Education and the National Research Foundation Singapore under an RCE grant awarded to the Singapore Centre for Environmental Life Sciences Engineering (SCELSE)