Exploring the COT Briefing Paper on Sustainable Development: reducing carbon without reducing health

The development of efficient and effective service delivery in health and social care, to meet the needs of service users in this changing world. WFOT 2012 has called for occupational therapy practice to incorporate sustainable development.Occupational therapists could re-evaluate practice models and expand clinical reasoning about occupational performance to include global issues.In the UK, Climate Change will bring new challenges to the way occupational therapists work. If action is taken now some of the worst effects of climate change could be mitigated or prevented. There could be also needs to be preparation and planning for the inevitable challenges to come.The occupational therapy profession has an important role to play in sustainable health and social care at all levels and across all domains

Use of an inertial navigation system for accurate track recovery and coastal oceanographic measurements

A data acquisition system using a Litton LTN-51 inertial navigation unit (INU) was tested and used for aircraft track recovery and for location and tracking from the air of targets at sea. The characteristic position drift of the INU is compensated for by sighting landmarks of accurately known position at discrete time intervals using a visual sighting system in the transparent nose of the Beechcraft 18 aircraft used. For an aircraft altitude of about 300 m, theoretical and experimental tests indicate that calculated aircraft and/or target positions obtained from the interpolated INU drift curve will be accurate to within 10 m for landmarks spaced approximately every 15 minutes in time. For applications in coastal oceanography, such as surface current mapping by tracking artificial targets, the system allows a broad area to be covered without use of high altitude photography and its attendant needs for large targets and clear weather

Biocatalytic Friedel-Crafts Reactions

Friedel-Crafts alkylation and acylation reactions are important methodologies in synthetic and industrial chemistry for the construction of aryl-alkyl and aryl-acyl linkages that are ubiquitous in bioactive molecules. Nature also exploits these reactions in many biosynthetic processes. Much work has been done to expand the synthetic application of these enzymes to unnatural substrates through directed evolution. The promise of such biocatalysts is their potential to supersede inefficient and toxic chemical approaches to these reactions, with mild operating conditions - the hallmark of enzymes. Complementary work has created many bio-hybrid Friedel-Crafts catalysts consisting of chemical catalysts anchored into biomolecular scaffolds, which display many of the same desirable characteristics. In this Review, we summarise these efforts, focussing on both mechanistic aspects and synthetic considerations, concluding with an overview of the frontiers of this field and routes towards more efficient and benign Friedel-Crafts reactions for the future of humankind