AN EXPERIMENTAL EVALUATION OF ANTI-INFLAMMATORY ACTION OF ROOT OF APARAJITA (CLITORIA TERNATEA LINN.) IN ALBINO RATS

Plants have played a major role in the production of biological compounds for the formation of drugs. Their role may either become a base for the development of medicine, a natural blue print for the development of new drugs or a phytomedicine to be used for the treatment of diseases. Acharya Charaka has quoted that none of the plants found around us are non-medicinal. Clitoria ternatea commonly known as Aparajita or Butterfly pea is a medicinal plant belonging to the family Fabaceae. In various Ayurvedic classics and Ayurvedic material medica, this plant is reported to be used in insect bites, skin diseases, asthma, burning sensation, inflammation, leucoderma, leprosy and pulmonary tuberculosis.A good number of anti-inflammatory drugs are available in modern medicine, among them some are expensive and some are having adverse effects in long term uses. Thus a need arises to find a safer and efficient drug from the natural resources, which will be simple, effective and not having any adverse effect. In the present study, preliminary phytochemical study and anti-inflammatory study of Kashayam (decoction) of root of Aparajita were carried out to confirm the presence of various phytochemical substances and to determine the anti-inflammatory action against diclofenac sodium in carrageenan induced rat paw edema model. The results of experimental study showed significant anti-inflammatory action of Kashayam (decoction) of Aparajita roots in acute inflammation compared to control and near to the action of diclofenac sodium, which suggests that Aparajita is potential natural anti-inflammatory drug

Comparative performance assessment of pineapple and Kevlar fibers based friction composites

Novel friction compositesmaterials usingpineapple fiber as a sustainable alternative for automotive industry were developedby increasing its amount from 5-20 wt.% in the step of 5 %. To compare the performance of pineapple fiber, friction composites with 5-10 wt.% of Kevlar fiber were also manufactured.The results of physico-mechanical properties reveal that density, hardnessand ash contentdecreasewhereas water absorption, porosity and compressibility increasewiththeincreased pineapple/Kevlar fiber contents. Further, the friction and fade performance were found to decrease whereastherecovery performance and wearwasfound to increase with increased pineapple fiber content. Among pineapple fiber reinforced composites, thebest compositeis the one having 5 wt.% pineapple fibersthat exhibits the highest performancein terms ofcoefficient of friction(0.548), lowest fade-% (36.31%)along withthelowest specific wearrate(3.49×10-8 cm3/N-m).Nonetheless,theresults showthat the5 wt.% Kevlar fiber based composite reveals good performance in terms of coefficient of friction (0.592) with slightly lower fade-% (35.98%), recovery-% (107.43%) and specific wear rate (3.46×10-8 cm3/N-m) when comparing to 5 wt.% pineapple fiber based composites.Finally, the possible wear mechanisms were discussed with the help of composites worn surface morphologies

Study of mechanical and abrasive wear behavior of glass fibre reinforced epoxy-talc/mustard cake hybrid compositions

In this work, the influence of inorganic/organic-inorganic filler on mechanical and sand abrasion wear behavior of glass fiber reinforced epoxy composites was investigated. An inorganic filler such as talc and organic filler like mustard cake with 0wt%, 5wt%, 10wt%, and 15wt% were loaded in glass epoxy composites by hand lay-up technique. The mechanical properties such as tensile strength, impact energy, and hardness was carried out on the fabricated specimens. It was found that the incorporation of talc/talc-mustard cake filler content to the glass fiber reinforced composites leads to decrease the tensile strength beyond the 10wt% and impact energy beyond 5wt%, on the other hand, it increases the hardness of the composites. Furthermore, this paper report the synergistic effect of talc-mustard cake filler on abrasion wear behavior of glass fiber reinforced composites by using Taguchi L 16 orthogonal array technique. The result showed that abrasion wear resistance increase with increases the talc/talc-mustard cake content in composites. Normal load, talc/talc-mustard cake content, and abrading distance showed a decreasing order of significance. Analysis of variance (ANOVA) was used to analyze the contribution (%) of selected control factor on wear behavior of composites. Afterword, the wear mechanism of worn surface was examined by SEM (scanning electron microscopy) to correlate the experimental result and shows higher wear occur at unfilled glass epoxy composites compared to talc/talc-mustard cake filled glass-epoxy composites

TREND statement checklist.

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Flowchart of the study.

Flowchart of the study.</p

S1 Protocol -

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Comparative results for Distant Recurrence (311 samples).

The column of the model utilizing only clinical data from our previous study [6] is included for comparison.</p

Comparative results for Locoregional Recurrence (311 samples).

The column of the model utilizing only clinical data from our previous study [6] is included for comparison.</p

Demographics of the retrospectively collected data of HNSCC (n = 311).

Demographics of the retrospectively collected data of HNSCC (n = 311).</p