Coupling of Two Motor Proteins: a New Motor Can Move Faster

We study the effect of a coupling between two motor domains in highly-processive motor protein complexes. A simple stochastic discrete model, in which the two parts of the protein molecule interact through some energy potential, is presented. The exact analytical solutions for the dynamic properties of the combined motor species, such as the velocity and dispersion, are derived in terms of the properties of free individual motor domains and the interaction potential. It is shown that the coupling between the motor domains can create a more efficient motor protein that can move faster than individual particles. The results are applied to analyze the motion of helicase RecBCD molecules

Air pollution, pulmonary oxidative stress, and the endothelin system in the development of cardiovascular injury.

The goal of this project was to examine the role of endothelin-1 (ET-1) as a mediator in the pathway between air pollution exposure and the development of vascular injury. A human cohort and male mice (C57BL/6 and ecSOD-Tg) were used to evaluate changes in the ET-1 system in response to exposures of fine particulate matter (PM2.5). Human ET-1 levels were significantly associated with environmental factors and markers of vascular change, but were decreased with increased PM2.5. No association was seen between ET-1 and endothelial progenitor cells (EPCs) except for EPC-4, possibly indicating a regulatory relationship with this specific population. In mice, the expression of the ET-1 system in the cardiopulmonary tissues changed significantly with exposure, with changes varying between exposure conditions. A potentially protective effect was seen in the lungs of ecSOD-Tg animals. These data suggest that ET-1 plays an important role in the vascular response to PM2.5 exposure

Short communications: Should the Brown-headed Apalis Apalis alticola be on the Kenya list?

No abstrac

Non-Perturbative One-Loop Effective Action for Electrodynamics in Curved Spacetime

In this paper we explicitly evaluate the one-loop effective action in four dimensions for scalar and spinor fields under the influence of a strong, covariantly constant, magnetic field in curved spacetime. In the framework of zeta function regularization, we find the one-loop effective action to all orders in the magnetic field up to linear terms in the Riemannian curvature. As a particular case, we also obtain the one-loop effective action for massless scalar and spinor fields. In this setting, we found that the vacuum energy of charged spinors with small mass becomes very large due entirely by the gravitational correction.Comment: LaTeX, 23 page

Investigating people: a qualitative analysis of the search behaviours of open-source intelligence analysts

The Internet and the World Wide Web have become integral parts of the lives of many modern individuals, enabling almost instantaneous communication, sharing and broadcasting of thoughts, feelings and opinions. Much of this information is publicly facing, and as such, it can be utilised in a multitude of online investigations, ranging from employee vetting and credit checking to counter-terrorism and fraud prevention/detection. However, the search needs and behaviours of these investigators are not well documented in the literature. In order to address this gap, an in-depth qualitative study was carried out in cooperation with a leading investigation company. The research contribution is an initial identification of Open-Source Intelligence investigator search behaviours, the procedures and practices that they undertake, along with an overview of the difficulties and challenges that they encounter as part of their domain. This lays the foundation for future research in to the varied domain of Open-Source Intelligence gathering