Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model.

BACKGROUND: We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD. Internal, predictive, and external validity of the model have not yet been established. METHODS: The Rotterdam Ischemic Heart Disease and Stroke Computer Simulation (RISC) model was developed using data covering 5 years of follow-up from the Rotterdam Study. To prove 1) internal and 2) predictive validity, the incidences of coronary heart disease (CHD), stroke, CVD death, and non-CVD death simulated by the model over a 13-year period were compared with those recorded for 3,478 participants in the Rotterdam Study with at least 13 years of follow-up. 3) External validity was verified using 10 years of follow-up data from the European Prospective Investigation of Cancer (EPIC)-Norfolk study of 25,492 participants, for whom CVD and non-CVD mortality was compared. RESULTS: At year 5, the observed incidences (with simulated incidences in brackets) of CHD, stroke, and CVD and non-CVD mortality for the 3,478 Rotterdam Study participants were 5.30% (4.68%), 3.60% (3.23%), 4.70% (4.80%), and 7.50% (7.96%), respectively. At year 13, these percentages were 10.60% (10.91%), 9.90% (9.13%), 14.20% (15.12%), and 24.30% (23.42%). After recalibrating the model for the EPIC-Norfolk population, the 10-year observed (simulated) incidences of CVD and non-CVD mortality were 3.70% (4.95%) and 6.50% (6.29%). All observed incidences fell well within the 95% credibility intervals of the simulated incidences. CONCLUSIONS: We have confirmed the internal, predictive, and external validity of the RISC model. These findings provide a basis for analyzing the effects of modifying cardiovascular disease risk factors on the burden of CVD with the RISC model.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

3D characterization of CdSe nanoparticles attached to carbon nanotubes

The crystallographic structure of CdSe nanoparticles attached to carbon nanotubes has been elucidated by means of high resolution transmission electron microscopy and high angle annular dark field scanning transmission electron microscopy tomography. CdSe rod-like nanoparticles, grown in solution together with carbon nanotubes, undergo a morphological transformation and become attached to the carbon surface. Electron tomography reveals that the nanoparticles are hexagonal-based with the (001) planes epitaxially matched to the outer graphene layer.Comment: 7 pages, 8 figure

Molecular Clusters in Mesoporous Materials as Precursors to Nanoparticles of a New Lacunar Ternary Compound PdxMoyP

Bimetallic clusters of composition Pd2Mo2(g5-C5H5)2(l3-CO)2(l2-CO)4 (PR3)2 (R = ethyl or phenyl) were incorporated by impregnation from solution into two different silica matrices, amorphous xerogels and ordered SBA-15, and a study of their thermal decomposition under a reducing atmosphere is reported. With both matrices, a suitable thermal treatment afforded nanoparticles of a new bimetallic phosphide. Although nanoparticles of composition PdxMoyP, isostructural with Mo3P, were formed in both matrices, they were more uniformly distributed in the SBA-15 framework and showed a narrower size distribution. The samples have been characterized by powder XRD, chemical analysis, FT-IR spectroscopy, TEM and electron tomography (3D TEM)

A revision of the spider genus Raveniola (Araneae, Nemesiidae). I. Species from Western Asia

WOS: 000424323000001The genus Raveniola Zonstein, 1987 is found to be represented in Western Asia by 16 species: male female R. adjarica sp. nov. (Georgia), male R. anadolu sp. nov. (Turkey), male R. arthuri Kunt & Yagmur, 2010 (Turkey), male R. birecikensis sp. nov. (Turkey), male female R. dunini sp. nov. (Armenia, Azerbaijan, Iran), male female R. hyrcanica Dunin, 1988 (Azerbaijan),male R. marusiki sp. nov. (Iran), male R. mazandaranica Marusik, Zamani & Mirshamsi, 2014 (Iran), male female R. micropa (Ausserer, 1871) (Turkey), female R. nana sp. nov. (Turkey), male female R. niedermeyeri (Brignoli, 1972) (Iran), male female R. pontica (Spassky, 1937) (Russia, Georgia), female R. sinani sp. nov. (Turkey), male female R. turcica sp. nov. (Turkey), male female R. vonwicki Zonstein, 2000 (Iran) and male female R. zaitzevi (Charitonov, 1948) (Azerbaijan, Georgia) = female Brachythele recki Mcheidze, 1983, syn. nov. Eight species are described as new; others are redescribed from types and/or conspecific material. Males of R. micropa and R. zaitzevi, hitherto unknown, are described for the first time. Data on the variability, relationships, distribution and ecology of all considered species are also provided.Ministry of Absorption, IsraelWe thank Yuri Marusik (Institute for Biological Problems of the North, Magadan), Vladimir Ovcharenko (the former curator of the ZISP spider collection), Peter Schwendinger (MHNG), Shuqiang Li (ICAZ), Peter Jager and Julia Altmann (SMF), Nikolai Pakhorukov (the former curator of the MZPU spider collection), Alexander Koval (VIZR), the late Pyotr Dunin (Baku, Azerbaijan, later Tolyatti, Russia), Kirill Mikhailov (ZMMU), Jurgen Gruber (the former curator of the NMW spider collection), Christine Rollard and Elise-Anne LeGuin (MNHN), and Laura Leibensperger (MCZ) for providing nemesiid specimens for study. We are grateful to our Turkish colleagues, Rahsen Kaya (Uludag University, Bursa) and Recep Sulhi Ozkutuk (Anadolu University, Eskisehir), for help and assistance while collecting in Turkey in September 2010 and Mehmet Ozkoruk for his help during field trips in south-eastern Anatolia. Our colleagues Mykola Kovblyuk (Tavrida University, Crimea) and Natalia Snegovaya (Research Institute of Zoology, Baku) kindly provided us with photographs of relevant Caucasian landscapes. Kadir Kunt and Ersen Yagmur thank Alireza Zamani (University of Tehran, Iran) for photographs showing nemesiid localities in Iran, live spiders and their retreats. Special thanks go to Seppo Koponen (ZMUT) for providing us with museum facilities. An early draft of the manuscript was kindly edited by Naomi Paz (TAU). We thank Shuqiang Li and Peter Schwendinger for their valuable comments and recommendations which helped to improve the original manuscript. This study was supported in part by the Ministry of Absorption, Israel

Initiation of health-behaviour change among employees participating in a web-based health risk assessment with tailored feedback

<p>Abstract</p> <p>Background</p> <p>Primary prevention programs at the worksite can improve employee health and reduce the burden of cardiovascular disease. Programs that include a web-based health risk assessment (HRA) with tailored feedback hold the advantage of simultaneously increasing awareness of risk and enhancing initiation of health-behaviour change. In this study we evaluated initial health-behaviour change among employees who voluntarily participated in such a HRA program.</p> <p>Methods</p> <p>We conducted a questionnaire survey among 2289 employees who voluntarily participated in a HRA program at seven Dutch worksites between 2007 and 2009. The HRA included a web-based questionnaire, biometric measurements, laboratory evaluation, and tailored feedback. The survey questionnaire assessed initial self-reported health-behaviour change and satisfaction with the web-based HRA, and was e-mailed four weeks after employees completed the HRA.</p> <p>Results</p> <p>Response was received from 638 (28%) employees. Of all, 86% rated the program as positive, 74% recommended it to others, and 58% reported to have initiated overall health-behaviour change. Compared with employees at low CVD risk, those at high risk more often reported to have increased physical activity (OR 3.36, 95% CI 1.52-7.45). Obese employees more frequently reported to have increased physical activity (OR 3.35, 95% CI 1.72-6.54) and improved diet (OR 3.38, 95% CI 1.50-7.60). Being satisfied with the HRA program in general was associated with more frequent self-reported initiation of overall health-behaviour change (OR 2.77, 95% CI 1.73-4.44), increased physical activity (OR 1.89, 95% CI 1.06-3.39), and improved diet (OR 2.89, 95% CI 1.61-5.17).</p> <p>Conclusions</p> <p>More than half of the employees who voluntarily participated in a web-based HRA with tailored feedback, reported to have initiated health-behaviour change. Self-reported initiation of health-behaviour change was more frequent among those at high CVD risk and BMI levels. In general employees reported to be satisfied with the HRA, which was also positively associated with initiation of health-behaviour change. These findings indicate that among voluntary participating employees a web-based HRA with tailored feedback may motivate those in greatest need of health-behaviour change and may be a valuable component of workplace health promotion programs.</p

Subaqueous fault scarps of the North Anatolian Fault in the Gulf of Saros (NE Aegean); where is the western limit of the 1912 Murefte-Sarkoy earthquake rupture?

The westernmost segment of the North Anatolian fault in NW Turkey lies mostly offshore, in the Sea of Marmara and the Gulf of Saros (NE Aegean), respectively to the E and W of a 45 km inland central portion. The 9 August 1912 Murefte-Sarkoy (M-s 7.4) and 13 September 1912 (M-s 6.8) earthquakes occurred along this segment. To date, the segment was studied mostly onshore although estimated magnitude and location suggest an offshore extension. Recent studies show the eastern rupture extension in the Sea of Marmara, while its western counterpart in the Gulf of Saros remains less documented. Here we use new observations from high-resolution marine geophysical data (multibeam bathymetry, side-scan-sonar, and seismic reflection profiles), to constrain the offshore 1912 ruptures in the Gulf of Saros. Detailed mapping of the subaqueous fine-scale morphology and structure of the fault provides a new insight for the western limit of the two 1912 surface ruptures. Distribution of fresh scarps, 3-D structural reconstructions, the complexity of fault segments, and the recent seismicity, altogether suggest that the western termination of the 1912 rupture(s) ends 37 km offshore in the Gulf of Saros. Following the 1999 Kocaeli earthquake, in the eastern Sea of Marmara, the unruptured segment length between the 1999 and 1912 ruptures became a critical issue, because of its implication for future earthquakes in the so-called Marmara seismic gap. If a 150-160 km total rupture length for the two 1912 earthquakes is assumed, a western rupture termination point at the inner Saros basin margin means that the eastern extension of the 9 August earthquake rupture reached the Central Marmara Basin. This outcome necessarily has implications for the seismic hazard in the Marmara coastal area that includes the Istanbul metropolitan area.ITU EMCOL (Turkey); CNR ISMAR (Italy) project 'Evaluating the Seismic Risk in the Sea of Marmara'We thank Captain Lubrano, Captain Lembo, CaptainGentile and the crew of R/V Urania for their invaluable assistance during all the Sea of Marmara and NE Aegean cruises. Naci Gorur coordinated the bilateral Turkish-Italian scientific project in Marmara. The.Istanbul MetropolitanMunicipality (IBB) funded partially the. ITU EMCOL (Turkey) & CNR ISMAR (Italy) project `Evaluating the Seismic Risk in the Sea of Marmara' (Turkish title: Marmara Denizi'nde Deprem Riskinin De.gerlendirilmesi) during the 2005 Urania cruise. The side-scan-sonar and chirp profile data used in the paper are available at the ISMAR repository at http://www.ismar.cnr.it/produ cts/data-sharing

Rhodium oxide surface-loaded gas sensors

In order to increase their stability and tune-sensing characteristics, metal oxides are often surface-loaded with noble metals. Although a great deal of empirical work shows that surface-loading with noble metals drastically changes sensing characteristics, little information exists on the mechanism. Here, a systematic study of sensors based on rhodium-loaded WO₃, SnO₂, and In₂O₃—examined using X-ray diffraction, high-resolution scanning transmission electron microscopy, direct current (DC) resistance measurements, operando diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy, and operando X-ray absorption spectroscopy—is presented. Under normal sensing conditions, the rhodium clusters were oxidized. Significant evidence is provided that, in this case, the sensing is dominated by a Fermi-level pinning mechanism, i.e., the reaction with the target gas takes place on the noble-metal cluster, changing its oxidation state. As a result, the heterojunction between the oxidized rhodium clusters and the base metal oxide was altered and a change in the resistance was detected. Through measurements done in low-oxygen background, it was possible to induce a mechanism switch by reducing the clusters to their metallic state. At this point, there was a significant drop in the overall resistance, and the reaction between the target gas and the base material was again visible. For decades, noble metal loading was used to change the characteristics of metal-oxide-based sensors. The study presented here is an attempt to clarify the mechanism responsible for the change. Generalities are shown between the sensing mechanisms of different supporting materials loaded with rhodium, and sample-specific aspects that must be considered are identified

Network Centrality and Pension Fund Performance

We analyze the relation between the location of a pension fund in its network and the investment performance, risk taking, and flows of the fund. Our approach analyzes the centrality of the fund's management company by examining the number of connections it has with other management companies through their commonality in managing for the same fund sponsors or through the same fund consultants. Network centrality is found to be positively associated with risk-adjusted return performance and growth in assets under management, after controlling for size and past performance, for domestic asset classes; however, we do not find this relation for foreign equity holdings. These findings indicate that local information advantages, which are much stronger among managers holding locally based stocks, exhibit positive externalities among connected managers. Of particular note is that we do not find that the centrality of a manager within one asset class (e.g., domestic bonds) helps the performance of the manager in another asset class (e.g., domestic equity), further indicating that our network analysis uncovers information diffusion effects. Network connections established through consultants are found to be particularly significant in explaining performance and fund flows, consistent with consultants acting as an important information conduit through which managers learn about each other's actions. Moreover, the importance of network centrality is strongest for larger funds, controlling for any economic scale effects. Better connected funds are also better able to attract higher net inflows for a given level of past return performance. Finally, more centrally placed fund managers are less likely to be fired after spells of low performance. Our results indicate that networks in asset management are one key source of the dissemination of private information about security values