The Ursinus Weekly, February 6, 1939

Byron sisters find adults \u27suggestible\u27 • Court five defeats Lebanon Valley, PMC during week • Walton to return for coming Lorelei dance • Ursinus bowery night planned for February 24 in gymnasium • McClure named to official post • Ursinus students and faculty to attend Temple conference • Fraternity bids to be extended Wednesday; today marks beginning of sorority rushing • Alumnus to address society • Curtain Club tryouts tomorrow • Men captain dean\u27s list by slight edge; Stine, five women\u27s halls tie for minority • Women debate Swarthmore • Official praises college med school record • Montgomery County alumni to dine, dance, on February 17 • Philadelphia men meet • Temple matmen trounce Stevens\u27 proteges, capture all bouts in season\u27s inaugural • Cubs beat Lighthouse, lose to Perkiomen • Ursinus to vie with LaSalle in sports quiz next Monday • Male forencists argue over radio with Penn Saturday • Standard college ring here in two weeks • Five new freshmen enrolled as sixteen students leave • German clubbers sing folk songs at Tuesday meeting • Vocal scholarships offered • Photon to be published soon • Miss Reber, Heyen represent Ursinus at weekend conclavehttps://digitalcommons.ursinus.edu/weekly/1859/thumbnail.jp

The Lantern Vol. 6, No. 2, March 1938

• Among Our Contributors • Of Special Interest To You! • Jenny Lee • The Arguments Against Isolation • The Note • Visit of the Grandchildren • One Finds God • To The North Lies New Hampshire • The Two Camps in Washington • Substitutes • At Times It Seems So Very Strange • Episode on a Lake Shore • My Campus Song • Irony • A Chinese Mysteryhttps://digitalcommons.ursinus.edu/lantern/1017/thumbnail.jp

The Lantern Vol. 7, No. 2, March 1939

• Editorial • Easter Eggs • Fever • Sonnets to the Planet We Call Earth • Asking Her Father • New Hampshire Ghost Story • Mary • On Approaching Death • On Turning Over a New Leaf • In Defense of Americanism • What is this Love? • Martyrs of Progress • Recurring • Splintershttps://digitalcommons.ursinus.edu/lantern/1013/thumbnail.jp

The Lantern Vol. 7, No. 2, March 1939

• Editorial • Easter Eggs • Fever • Sonnets to the Planet We Call Earth • Asking Her Father • New Hampshire Ghost Story • Mary • On Approaching Death • On Turning Over a New Leaf • In Defense of Americanism • What is this Love? • Martyrs of Progress • Recurring • Splintershttps://digitalcommons.ursinus.edu/lantern/1013/thumbnail.jp

The Lantern Vol. 4, No. 2, March 1936

• Cooperative Democracy • Fantasy • Drama: Porgy and Bess • Foreign Entanglements • The Kibitzer • My Gallery of Old Folks • My Friend, Mark Twain • Jimmy and Waffles • Reminiscence • Gold Dust • After Twenty Centuries • All the World\u27s a Stage • Early Medicinehttps://digitalcommons.ursinus.edu/lantern/1007/thumbnail.jp

The Lantern Vol. 6, No. 1, December 1937

• After Thinking Things Over • Ho! Ho! The Mistletoe! • Unrealized Dreams • Two Preeminent Victorians • The Thing • Progression • It Wasn\u27t in the Lines • He Was the Most Perfect Man • College (C)lasses • Robins and Roses • The Commuter • When the Rose is Dead • Truth in Print • Alias Mike Romanoff • Winslow Homer • When I Was Young • Maurice Evans, a Great Shakespearean • Among Our Contributors • Of Manx and Man • A Sanguinary Pirate • Conversation Has an Adventure • Ursinus\u27 Neediest Casehttps://digitalcommons.ursinus.edu/lantern/1016/thumbnail.jp

The Lantern Vol. 5, No. 1, December 1936

• All of Us • Public Dance • In Tibet, of All Places • Thoughts • Subterranean Conflict on the Campus • Out, Out Into Fragrance and Sweetness • My Soul Steals Out to Meet You In the Night • Bored Young Lady • Guay Shin\u27s Prayer • On Playing Ping-Pong • The Love-Life of One Cat and the Death of Another • My Lady • Danger! Germs Working! • The Wolves • Letters from India • With Apologies to Hamlet • The Dreamhttps://digitalcommons.ursinus.edu/lantern/1015/thumbnail.jp

The Lantern Vol. 5, No. 3, May 1937

• Dedication • Dr. McClure: An Ursinus Man • Roar, O Wind! • To the Ladies! • The Futility of Dying • The Symbolism of the British Crown • Oh! • It Might Have Been • Treat Yourself? • Three Writers • Hawaii in June • On Being a Twin • Black Magic • Triangle • Who Longs? • A Son Passes • Sing an Old-Fashioned Song • Questioning • An Argument About a Fish • That Morning Eye-Opener • Scoop for the Sun • The Dead Do Not Die Once • Give Us Timehttps://digitalcommons.ursinus.edu/lantern/1010/thumbnail.jp

Tau Reduction Does Not Prevent Motor Deficits in Two Mouse Models of Parkinson's Disease

Many neurodegenerative diseases are increasing in prevalence and cannot be prevented or cured. If they shared common pathogenic mechanisms, treatments targeting such mechanisms might be of benefit in multiple conditions. The tau protein has been implicated in the pathogenesis of diverse neurodegenerative disorders, including Alzheimer's disease (AD) and Parkinson's disease (PD). Tau reduction prevents cognitive deficits, behavioral abnormalities and other pathological changes in multiple AD mouse models. Here we examined whether tau reduction also prevents motor deficits and pathological alterations in two mouse models of PD, generated by unilateral striatal injection of 6-hydroxydopamine (6-OHDA) or transgene-mediated neuronal expression of human wildtype α-synuclein. Both models were evaluated on Tau+/+, Tau+/– and Tau–/– backgrounds in a variety of motor tests. Tau reduction did not prevent motor deficits caused by 6-OHDA and slightly worsened one of them. Tau reduction also did not prevent 6-OHDA-induced loss of dopaminergic terminals in the striatum. Similarly, tau reduction did not prevent motor deficits in α-synuclein transgenic mice. Our results suggest that tau has distinct roles in the pathogeneses of AD and PD and that tau reduction may not be of benefit in the latter condition