Criminal Law and Procedure—Waiver of Trial by Jury in Criminal Cases

People v. Duchin, 12 N.Y.2d 351, 190 N.E.2d 17, 239 N.Y.S.2d 670 (1963)

Contracts—Contract Intended To Release Liability For Negligence Invalidated—Language Not Sufficiently Explicit

Willard Van Dyke Prods. v. Eastman Kodak Co., 12 N.Y.2d 301, 189 N.E.2d 693, 239 N.Y.S.2d 337 (1963)

Technology as a scapegoat

Not Include

Protein Methylation and Stress Granules: Posttranslational Remodeler or Innocent Bystander?

Stress granules contain a large number of post-translationally modified proteins, and studies have shown that these modifications serve as recruitment tags for specific proteins and even control the assembly and disassembly of the granules themselves. Work originating from our laboratory has focused on the role protein methylation plays in stress granule composition and function. We have demonstrated that both asymmetrically and symmetrically dimethylated proteins are core constituents of stress granules, and we have endeavored to understand when and how this occurs. Here we seek to integrate this data into a framework consisting of the currently known post-translational modifications affecting stress granules to produce a model of stress granule dynamics that, in turn, may serve as a benchmark for understanding and predicting how post-translational modifications regulate other granule types

Conformational-Dependent and Independent RNA Binding to the Fragile X Mental Retardation Protein

The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts produced by in vitro transcription contain a population of conformers, which can be modulated by preannealing. Accordingly, FMRP differentially binds to the annealed and unannealed conformer populations. Using partial RNase digestion, we demonstrate that annealed BC1 RNA contains a unique conformer that FMRP likely binds. We further demonstrate that this interaction is 100-fold weaker than that the binding of eEF-1A mRNA and FMRP, and that preannealing is not a general requirement for FMRP's interaction with RNA. In addition, binding does not require the N-terminal 204 amino acids of FMRP, methylated arginine residues and can be recapitulated by both fragile X paralogs. Altogether, our data continue to support a model in which BC1 RNA functions independently of FMRP

The Emergence of Trans-Regional Educational Exchange Schemes (TREES) in Europe, North America, and the Asia-Pacific Region

This article demonstrates that salient aspects of globalization have led to the emergence of trans-regional educational exchange schemes (TREES) in higher education. What sets these schemes apart from others is the proliferation of international university organizations that "go beyond region" and infiltrate other parts of the globe despite policy barriers. This article illustrates how the current globalizing efforts to establish regionalized free trade zones, as evidenced in such organizations as the European Union (EU), the North America Free Trade Agreement (NAFTA), and the Asia-Pacific Economic Co-operation Zone (APEC) have led to processes of internationalization in which national governments, higher education institutions, and other international university organizations vie for position. It concludes with a discussion of selected strategies and issues as these affect the development of international university co-operation as a whole and the impact they may have on higher education in the future

Globalisation and Its Impact on International University Cooperation

Globalisation is conceptually ambiguous. Not only is it used in contexts such as process, perspective, and outcome, and loosely defined in various dimensions (i.e. political, economic, socio-cultural), it is also commonly mistaken for internationalisation. Although most literature treating globalisation is economic in focus, this study attempts to investigate its ubiquitous nature in an effort to arrive at a more comprehensive understanding of globalisation within the particular domain of higher education. For purposes of this study, globalisation in higher education pertains to a convergence of educational systems and ideals designed to meet the needs of world knowledge (dissemination and pursuit thereof) and societal advancement (civilisation-building). Internationalisation refers to the divergent approaches within the various contexts of that convergence. The analysis of 600 + international university organisations, viewed as outcomes of globalisation, internationalisation, and other spheres of influence, provides tangible evidence of these forces and their impact on higher education, and more particularly, on international university cooperation

Self-relevant disgust and self-harm urges in patients with borderline personality disorder and depression: a pilot study with a newly designed psychological challenge.

BACKGROUND: Borderline personality disorder (BPD) is a common psychiatric condition associated with self-harm. Self-harm is poorly understood and there is currently no treatment for acute presentations with self-harm urges. OBJECTIVES: By using a new task (Self-relevant Task; SRT), to explore emotions related to one's own person (PERSON task) and body (BODY task), to study the correlations of these emotions, specifically disgust, with self-harm urge level changes, and to test the task's potential to be developed into an experimental model of self-harming for treatment trials. METHODS: 17 BPD patients, 27 major depressive disorder (MDD) patients, and 25 healthy volunteers performed the SRT. Emotion labels were extracted from task narratives and disgust and self-harm urge level changes measured by visual analogue scales. We used validated rating scales to measure symptom severity. RESULTS: The SRT was effective at inducing negative emotions and self-harm urge changes. Self-harm urge changes correlated with borderline symptom severity. Post-task disgust levels on the visual analogue scales were higher in BPD patients than in healthy controls in the PERSON task, and higher than in both control groups in the BODY task. Changes in disgust levels during the task were significantly greater in the patient groups. Post-task disgust levels or changes in disgust were not associated with self-harm urge changes (except the latter in MDD in the PERSON task), but self-harm urge changes and disgust (but no other emotion) narrative labels were on a whole sample level. CONCLUSION: Although associations with the analogue scale measures were not significant, self-disgust reported in the narrative of patients may be associated with a higher probability of self-harm urges. Further research with larger sample sizes is needed to confirm this relationship and to examine whether reducing self-disgust could reduce self-harm urges. The SRT was effective and safe, and could be standardized for experimental studies.This work was partly funded by a Core Award from the Medical Research Council and the Wellcome Trust to the Behavioural and Clinical Neuroscience Institute (MRC Ref G1000183; WT Ref 093875/Z/10/Z). Sawsan Abdul-Hamid received a grant from the Evelyn Trust to help to cover the costs of her research placement with the research group. The Talisman Trust also supported the study with a grant.This is the final published version, which can also be found on the PLoS website here: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0099696#ac

Simulation Study of TenTen: A new Multi-TeV IACT array

TenTen is a proposed array of Imaging Atmospheric Cherenkov Telescopes (IACT) optimized for the gamma ray energy regime of 10 TeV to 100 TeV, but with a threshold of ~1 to a few TeV. It will offer a collecting area of 10 km2 above energies of 10 TeV. In the initial phase, a cell of 3 to 5 modest-sized telescopes, each with 10-30 m2 mirror area, is suggested for an Australian site. A possible expansion of the array could comprise many such cells. Here we present work on configuration and technical issues from our simulation studies of the array. Working topics include array layout, telescope size and optics, camera field of view, telescope trigger system, electronics, and site surveys.Comment: 4 pages, 7 figures, submitted to Proceedings of the ICRC 2007, pdf forma