Recent Developments in Robocasting of Ceramics and Multimaterial Deposition

Robocasting is a freeform fabrication technique for dense ceramics and composites that is based on layer-wise deposition of highly loaded colloidalslurries. The process is essentially binderless with less than 1% organics and parts can be fabricated, dried, and completely sintered in less than 24 hours. This overview will highlight recent materials developments for structural applications and modelling of slurry flow. Fabrication of preforms for alumina/metal composites will be discussed as well as techniques for multimaterial deposition in both graded structures and discrete placement of fugitive materials.Mechanical Engineerin

Evaluating the roles of directed breeding and gene flow in animal domestication

Peer reviewedPostprin

Forced Oscillation Wind Tunnel Testing for FASER Flight Research Aircraft

As unmanned air vehicles (UAVs) continue to expand their flight envelopes into areas of high angular rate and high angle of attack, modeling the complex unsteady aerodynamics for simulation in these regimes has become more difficult using traditional methods. The goal of this experiment was to improve the current six degree-of-freedom aerodynamic model of a small UAV by replacing the analytically derived damping derivatives with experimentally derived values. The UAV is named the Free-flying Aircraft for Sub-scale Experimental Research, FASER, and was tested in the NASA Langley Research Center 12- Foot Low-Speed Tunnel. The forced oscillation wind tunnel test technique was used to measure damping in the roll and yaw axes. By imparting a variety of sinusoidal motions, the effects of non-dimensional angular rate and reduced frequency were examined over a large range of angle of attack and side-slip combinations. Tests were performed at angles of attack from -5 to 40 degrees, sideslip angles of -30 to 30 degrees, oscillation amplitudes from 5 to 30 degrees, and reduced frequencies from 0.010 to 0.133. Additionally, the effect of aileron or elevator deflection on the damping coefficients was examined. Comparisons are made of two different data reduction methods used to obtain the damping derivatives. The results show that the damping derivatives are mainly a function of angle of attack and have dependence on the non-dimensional rate and reduced frequency only in the stall/post-stall regim

Evaluating the roles of directed breeding and gene flow in animal domestication

For the last 150 y scholars have focused upon the roles of intentional breeding and genetic isolation as fundamental to understanding the process of animal domestication. This analysis of ethnoarchaeological, archaeological, and genetic data suggests that long-term gene flow between wild and domestic stocks was much more common than previously assumed, and that selective breeding of females was largely absent during the early phases of animal domestication. These findings challenge assumptions about severe genetic bottlenecks during domestication, expectations regarding monophyletic origins, and interpretations of multiple domestications. The findings also raise new questions regarding ways in which behavioral and phenotypic domestication traits were developed and maintained

Identifying The Health Needs In Rural Appalachian Ohio: Outcomes Of A Rural Community-Academic Partnership

To identify health issues in two rural counties, a needs assessment was developed by health officials and researchers. Focus groups (n = 32) and interviews (n = 8) were conducted among community leaders and a modified BRFFS survey was completed by 399 community members. Results indicated the health of the participants was influenced by: 1) rural Appalachian culture, 2) geography and access to health care, and 3) lack of access/knowledge about preventive health behaviors. These issues likely contributed to 30% obesity prevalence among the sample, which was prioritized as the main health issue for both counties.

Place-based Politics and Nested Deprivation in the U.K.: Beyond Cities-towns, ‘Two Englands’ and the ‘Left Behind’

‘Place-based explanations’ of politics in the U.K. tell sweeping narratives about ‘Two Englands’, or of sizeable regions of the country that have been ‘Left Behind’, reinforcing popular accounts of a North–South or city-town divide. We introduce the concept of nested deprivation – deprivation that may occur in just one housing estate or even one row of flats within neighbourhoods that are otherwise affluent. We report on intensive fieldwork in 8 neighbourhoods varying in relative affluence and density of population (including urban, suburban/satellite, market town or rural village). Three key themes and consequences emerge for those living in nested deprivation in relatively affluent and geographically dispersed contexts: (a) either disconnection from or entrapment within the local economy; (b) social isolation and atomisation; and (c) powerlessness to affect politics. ‘Place-based’ explanations of rapid and radical changes to political participation in Britain need to take fine-grained geographical distinctions much more seriously. Our study provides evidence that the rising tides in affluent areas are drowning some residents rather than lifting all boats. Where deprivation is dispersed and then nested within mostly affluent constituencies it does not allow for the political mobilisation among communities of interest that is a necessary condition for pluralist representative democracies

Residence in a Distressed County in Appalachia as a Risk Factor for Diabetes, Behavioral Risk Factor Surveillance System, 2006-2007

Introduction We compared the risk of diabetes for residents of Appalachian counties to that of residents of non-Appalachian counties after controlling for selected risk factors in states containing at least 1 Appalachian county. Methods We combined Behavioral Risk Factor Surveillance System data from 2006 and 2007 and conducted a logistic regression analysis, with self-reported diabetes as the dependent variable. We considered county of residence (5 classifications for Appalachian counties, based on economic development, and 1 for non-Appalachian counties), age, sex, race/ethnicity, education, household income, smoking status, physical activity level, and obesity to be independent variables. The classification “distressed” refers to counties in the worst 10%, compared with the nation as a whole, in terms of 3-year unemployment rate, per capita income, and poverty. Results Controlling for covariates, residents in distressed Appalachian counties had 33% higher odds (95% confidence interval, 1.10-1.60) of reporting diabetes than residents of non-Appalachian counties. We found no significant differences between other classifications of Appalachian counties and non-Appalachian counties. Conclusions Residents of distressed Appalachian counties are at higher risk of diabetes than are residents of other counties. States with distressed Appalachian counties should implement culturally sensitive programs to prevent diabetes

Career-computer simulation increases perceived importance of learning about rare diseases

Background: Rare diseases may be defined as occurring in less than 1 in 2000 patients. Such conditions are, however, so numerous that up to 5.9% of the population is afflicted by a rare disease. The gambling industry attests that few people have native skill evaluating probabilities. We believe that both students and academics, under-estimate the likelihood of encountering rare diseases. This combines with pressure on curriculum time, to reduce both student interest in studying rare diseases, and academic content preparing students for clinical practice. Underestimation of rare diseases, may also contribute to unhelpful blindness to considering such conditions in the clinic. Methods: We first developed a computer simulation, modelling the number of cases of increasingly rare conditions encountered by a cohort of clinicians. The simulation captured results for each year of practice, and for each clinician throughout the entirety of their careers. Four hundred sixty-two theoretical conditions were considered, with prevalence ranging from 1 per million people through to 64.1% of the population. We then delivered a class with two in-class on-line surveys evaluating student perception of the importance of learning about rare diseases, one before and the other after an in-class real-time computer simulation. Key simulation variables were drawn from the student group, to help students project themselves into the simulation. Results: The in-class computer simulation revealed that all graduating clinicians from that class would frequently encounter rare conditions. Comparison of results of the in-class survey conducted before and after the computer simulation, revealed a significant increase in the perceived importance of learning about rare diseases (p < 0.005). Conclusions: The computer career simulation appeared to affect student perception. Because the computer simulation demonstrated clinicians frequently encounter patients with rare diseases, we further suggest this should be considered by academics during curriculum review and design

Understanding the informal aspects of medication processes to maintain patient safety in hospitals:a sociotechnical ethnographic study in paediatric units

Adverse drug events (ADEs) are common in hospitals, affecting one in six child in-patients. Medication processes are complex systems. This study aimed to explore the work-as-done of medication safety in three English paediatric units using direct observation and semi-structured interviews. We found that a combination of the physical environment, traditional work systems and team norms were among the systemic barriers to medicines safety. The layout of wards discouraged teamworking and reinforced professional boundaries. Workspaces were inadequate, and interruptions were uncontrollable. A less experienced workforce undertook prescribing and verification while more experienced nurses undertook administration. Guidelines were inadequate, with actors muddling through together. Formal controls against ADEs included checking (of prescriptions and administration) and barcode administration systems, but these did not integrate into workflows. Families played an important part in the safe administration of medication and provision of information about their children but were isolated from other parts of the system.</p

Increasing Doses of Intraoperative Hydromorphone Do Not Reduce Postoperative Pain

Introduction: • Intermediate and long acting opioids are given intraoperatively to reduce pain during emergence from anesthesia. • Recent evidence suggests that intraoperative opioids have inconsistent effects on nociception and pain in the immediate postoperative period. • Multiple potent, short-acting opioids such as remifentanil, sufentanil and fentanyl have been shown to produce dose-related increases in pain scores and opioid consumption in the immediate postoperative recovery period. • Intraoperative doses of longer acting opioids such as morphine and methadone6 have been shown to reduce pain scores and narcotic requirements in the immediate postoperative period. • Hydromorphone is an intermediate duration narcotic which is commonly used intraoperatively but has not been studied for its potential to reduce pain in the immediate postoperative period