1.16 Nickel-Catalyzed Bond Activation for Functional-Group Shuttling

AbstractFunctional-group shuttling, for example through shuttle catalysis or single-bond metathesis, has recently emerged as a powerful tool in targeted organic synthesis. This concept offers several advantages in comparison with traditional catalytic reactions. It enables the use of more-benign surrogates as formal functional-group donors, leading to safer reaction profiles. These reactions also often complement traditional cross-coupling reactions by allowing for base-free conditions, since no external inorganic reagent is required. Lately, nickel has emerged as an extremely useful transition metal in catalysis, complementing and often even surpassing the efficiency of noble metals, such as palladium. The focus of this chapter is to summarize recent developments in nickel-catalyzed functional-group-shuttling reactions.</jats:p

Paramètres contrôlant la géométrie des bassins d'avant-chaîne dans les chaînes alpines

Les bassins d'avant-chaîne s'édifient au front des chaînes à la suite d'une flexion de la lithosphère continentale. L'étude comparée de différents bassins permet de mettre en évidence les paramètres qui influent très étroitement sur leur évolution et leur géométri

Paramètres contrôlant la géométrie des bassins d'avant-chaîne dans les chaînes alpines

Les bassins d'avant-chaîne s'édifient au front des chaînes à la suite d'une flexion de la lithosphère continentale. L'étude comparée de différents bassins permet de mettre en évidence les paramètres qui influent très étroitement sur leur évolution et leur géométri

Nickel‐Catalyzed Inter‐ and Intramolecular Aryl Thioether Metathesis by Reversible Arylation

A nickel‐catalyzed aryl thioether metathesis has been developed to access high‐value thioethers. 1,2‐Bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional‐group‐tolerant reaction. Furthermore, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring‐closing metathesis that does not involve alkene bonds. In‐depth organometallic studies support a reversible Ni0/NiII pathway to product formation. Overall, this work not only provides a more sustainable alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information that are highly relevant to the further development and application of unusual single‐bond metathesis reactions