161 research outputs found

    Feshbach resonances in mixtures of ultracold 6^6Li and 87^{87}Rb gases

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    We report on the observation of two Feshbach resonances in collisions between ultracold 6^6Li and 87^{87}Rb atoms in their respective hyperfine ground states F,mF>=1/2,1/2>|F,m_F>=|1/2,1/2> and 1,1>|1,1>. The resonances show up as trap losses for the 6^6Li cloud induced by inelastic Li-Rb-Rb three-body collisions. The magnetic field values where they occur represent important benchmarks for an accurate determination of the interspecies interaction potentials. A broad Feshbach resonance located at 1066.92 G opens interesting prospects for the creation of ultracold heteronuclear molecules. We furthermore observe a strong enhancement of the narrow p-wave Feshbach resonance in collisions of 6^6Li atoms at 158.55 G in the presence of a dense 87^{87}Rb cloud. The effect of the 87^{87}Rb cloud is to introduce Li-Li-Rb three-body collisions occurring at a higher rate than Li-Li-Li collisions.Comment: 4 pages, 3 figure

    Quantum-degenerate mixture of fermionic lithium and bosonic rubidium gases

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    We report on the observation of sympathetic cooling of a cloud of fermionic 6-Li atoms which are thermally coupled to evaporatively cooled bosonic 87-Rb. Using this technique we obtain a mixture of quantum-degenerate gases, where the Rb cloud is colder than the critical temperature for Bose-Einstein condensation and the Li cloud colder than the Fermi temperature. From measurements of the thermalization velocity we estimate the interspecies s-wave triplet scattering length |a_s|=20_{-6}^{+9} a_B. We found that the presence of residual rubidium atoms in the |2,1> and the |1,-1> Zeeman substates gives rise to important losses due to inelastic collisions.Comment: 4 pages, 3 figure

    Phase-sensitive detection of Bragg scattering at 1D optical lattices

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    We report on the observation of Bragg scattering at 1D atomic lattices. Cold atoms are confined by optical dipole forces at the antinodes of a standing wave generated by the two counter-propagating modes of a laser-driven high-finesse ring cavity. By heterodyning the Bragg-scattered light with a reference beam, we obtain detailed information on phase shifts imparted by the Bragg scattering process. Being deep in the Lamb-Dicke regime, the scattered light is not broadened by the motion of individual atoms. In contrast, we have detected signatures of global translatory motion of the atomic grating.Comment: 4 pages, 4 figure

    Highly versatile atomic micro traps generated by multifrequency magnetic field modulation

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    We propose the realization of custom-designed adiabatic potentials for cold atoms based on multimode radio frequency radiation in combination with static inhomogeneous magnetic fields. For example, the use of radio frequency combs gives rise to periodic potentials acting as gratings for cold atoms. In strong magnetic field gradients the lattice constant can be well below 1 micrometer. By changing the frequencies of the comb in time the gratings can easily be propagated in space, which may prove useful for Bragg scattering atomic matter waves. Furthermore, almost arbitrarily shaped potential are possible such as disordered potentials on a scale of several 100 nm or lattices with a spatially varying lattice constant. The potentials can be made state selective and, in the case of atomic mixtures, also species selective. This opens new perspectives for generating tailored quantum systems based on ultra cold single atoms or degenerate atomic and molecular quantum gases.Comment: 12 pages, 6 figure

    BCS and BEC p-wave pairing in Bose-Fermi gases

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    The pairing of fermionic atoms in a mixture of atomic fermion and boson gases at zero temperature is investigated. The attractive interaction between fermions, that can be induced by density fluctuations of the bosonic background, can give rise to a superfluid phase in the Fermi component of the mixture. The atoms of both species are assumed to be in only one internal state, so that the pairing of fermions is effective only in odd-l channels. No assumption about the value of the ratio between the Fermi velocity and the sound velocity in the Bose gas is made in the derivation of the energy gap equation. The gap equation is solved without any particular "ansatz" for the pairing field or the effective interaction. The p-wave superfluidity is studied in detail. By increasing the strength and/or decreasing the range of the effective interaction a transition of the fermion pairing regime, from the Bardeen-Cooper-Schrieffer state to a system of tightly bound couples can be realized. These composite bosons behave as a weakly-interacting Bose-Einstein condensate.Comment: 14 pages, 6 eps-figures. To be published in European Physical Journal

    Preferential binding to elk-1 by sle-associated il10 risk allele upregulates il10 expression

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    Immunoregulatory cytokine interleukin-10 (IL-10) is elevated in sera from patients with systemic lupus erythematosus (SLE) correlating with disease activity. The established association of IL10 with SLE and other autoimmune diseases led us to fine map causal variant(s) and to explore underlying mechanisms. We assessed 19 tag SNPs, covering the IL10 gene cluster including IL19, IL20 and IL24, for association with SLE in 15,533 case and control subjects from four ancestries. The previously reported IL10 variant, rs3024505 located at 1 kb downstream of IL10, exhibited the strongest association signal and was confirmed for association with SLE in European American (EA) (P = 2.7×10−8, OR = 1.30), but not in non-EA ancestries. SNP imputation conducted in EA dataset identified three additional SLE-associated SNPs tagged by rs3024505 (rs3122605, rs3024493 and rs3024495 located at 9.2 kb upstream, intron 3 and 4 of IL10, respectively), and SLE-risk alleles of these SNPs were dose-dependently associated with elevated levels of IL10 mRNA in PBMCs and circulating IL-10 protein in SLE patients and controls. Using nuclear extracts of peripheral blood cells from SLE patients for electrophoretic mobility shift assays, we identified specific binding of transcription factor Elk-1 to oligodeoxynucleotides containing the risk (G) allele of rs3122605, suggesting rs3122605 as the most likely causal variant regulating IL10 expression. Elk-1 is known to be activated by phosphorylation and nuclear localization to induce transcription. Of interest, phosphorylated Elk-1 (p-Elk-1) detected only in nuclear extracts of SLE PBMCs appeared to increase with disease activity. Co-expression levels of p-Elk-1 and IL-10 were elevated in SLE T, B cells and monocytes, associated with increased disease activity in SLE B cells, and were best downregulated by ERK inhibitor. Taken together, our data suggest that preferential binding of activated Elk-1 to the IL10 rs3122605-G allele upregulates IL10 expression and confers increased risk for SLE in European Americans
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