L'etapa de provisionalitat institucional borbònica en els municipis catalans durant la Guerra de Successió (1707-1716)

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Finding network modules and motifs regulating plant stress responses : integration and model-ling across multiple data sets

In spite of constant technological advancements, world hunger remains a major challenge due to exponential population growth, and the loss of e effectiveness of crop treatments such as pesticides. As such, comprehending the plant response to stress is of great importance in breeding more resilient crops. Whilst different stresses elicit distinct responses from the plant, a core set of regulatory interactions are conserved across multiple responses and operate as networks. In this thesis, computational approaches were used to elucidate such regulatory interactions from time course expression datasets, predominantly through identification of genes co-expressed across multiple stimuli responses as a footprint of shared network co-regulation. The identification of such network footprints was tackled through Wigwams, a data mining algorithm capable of detecting groups of genes co-regulated across multiple datasets. In contrast to other algorithms, Wigwams assesses whether the co-expression it detects is likely to reflect co-regulation. The modules it found were significantly enriched in functionality and cis-regulatory elements, indicating actual co-regulation. Wigwams and other computational approaches were applied to time course expression data capturing Arabidopsis thaliana response to Pseudomonas syringae pv. tomato DC3000. The presence of a virulent and avirulent strain in the experiment allowed for the temporal deconstruction of the regulatory events underlying the virulent strain's attempts to overcome plant defence through effector action. This analysis led to the detection of a number of effector-specific transcription changes stifling the defence response and manipulating the host's gene and protein expression. A transcription factor-only regulatory network model was proposed to explain the detected network footprints. The inference of causal regulatory networks from expression data is a daunting task, and transcription factor-only models are a good computational compromise by capturing the key regulatory events taking place. However, they are lacking in target genes that carry out the functionality induced by the signalling, making functional assessment di cult. Wigwams was used to introduce the network footprint components into the corresponding transcription factor-only models, resulting in enhanced network models carrying information about downstream regulated genes. This allows for functional assessment to be used to identify nodes of interest within the network, and propose concise follow-up experiments

L'Africa romana: mobilità delle persone e dei popoli, dinamiche migratorie, emigrazioni ed immigrazioni nelle province occidentali dell’Impero romano: atti del 16. Convegno di studio

Questa XVI edizione dell’Africa romana, pubblicata per iniziativa del Dipartimento di Storia e del Centro di Studi Interdisciplinari sulle Province Romane dell’Università degli Studi di Sassari, dell’Institut National des Sciences de l’Archéologie et du Patrimoine del Marocco e dell’Université Hassan II di Mohammedia, contiene i testi delle oltre cento comunicazioni presentate a Rabat tra il 15 ed il 19 dicembre 2004, in occasione del Convegno internazionale dedicato al tema «Mobilità delle persone e dei popoli, dinamiche migratorie, emigrazioni ed immigrazioni nelle province occidentali dell’Impero romano», cui hanno partecipato oltre 250 studiosi, provenienti da 16 paesi europei ed extra-europei e che si è svolto sotto l’alto patronato di Sua Maestà il Re Mohamed VI e del Presidente della Repubblica italiana Carlo Azeglio Ciampi. Delineati gli aspetti generali, una sessione del convegno è stata dedicata specificamente alle relazioni tra Nord Africa e le altre province e una invece alle nuove scoperte epigrafiche; in parallelo si sono svolte mostre fotografiche e di poster, presentazioni di libri e novità bibliografiche, alcune esposizioni nel quartiere des Oudayas a Rabat e diverse escursioni con visite ai monumenti tra Volubilis, Lixus e Sala colonia.<br/

Plant Signaling Molecule: Role and Regulation under Stressful Environments

Plant Signaling Molecule: Role and Regulation under Stressful Environments explores tolerance mechanisms mediated by signaling molecules in plants for achieving sustainability under changing environmental conditions. Including a wide range of potential molecules, from primary to secondary metabolites, the book presents the status and future prospects of the role and regulation of signaling molecules at physiological, biochemical, molecular and structural level under abiotic stress tolerance. This book is designed to enhance the mechanistic understanding of signaling molecules and will be an important resource for plant biologists in developing stress tolerant crops to achieve sustainability under changing environmental conditions