Z3_3-graded differential geometry of quantum plane

In this work, the Z$_3$-graded differential geometry of the quantum plane is constructed. The corresponding quantum Lie algebra and its Hopf algebra structure are obtained. The dual algebra, i.e. universal enveloping algebra of the quantum plane is explicitly constructed and an isomorphism between the quantum Lie algebra and the dual algebra is given.Comment: 17 page

ATHENA: A Phase 3, Open-Label Study Of The Safety And Effectiveness Of Oliceridine (TRV130), A G-Protein Selective Agonist At The µ-Opioid Receptor, In Patients With Moderate To Severe Acute Pain Requiring Parenteral Opioid Therapy.

Background:Pain management with conventional opioids can be challenging due to dose-limiting adverse events (AEs), some of which may be related to the simultaneous activation of β-arrestin (a signaling pathway associated with opioid-related AEs) and G-protein pathways. The investigational analgesic oliceridine is a G-protein-selective agonist at the µ-opioid receptor with less recruitment of β-arrestin. The objective of this phase 3, open-label, multi-center study was to evaluate the safety and tolerability, of IV oliceridine for moderate to severe acute pain in a broad, real-world patient population, including postoperative surgical patients and non-surgical patients with painful medical conditions. Methods:Adult patients with a score ≥4 on 11-point NRS for pain intensity received IV oliceridine either by bolus or PCA; multimodal analgesia was permitted. Safety was assessed using AE reports, study discontinuations, clinical laboratory and vital sign measures. Results:A total of 768 patients received oliceridine. The mean age (SD) was 54.1 (16.1) years, with 32% ≥65 years of age. Most patients were female (65%) and Caucasian (78%). Surgical patients comprised the majority of the study population (94%), most common being orthopedic (30%), colorectal (15%) or gynecologic (15%) procedures. Multimodal analgesia was administered to 84% of patients. Oliceridine provided a rapid reduction in NRS pain score by 2.2 ± 2.3 at 30 mins from a score of 6.3 ± 2.1 (at baseline) which was maintained to the end of treatment. No deaths or significant cardiorespiratory events were reported. The incidence of AEs leading to early discontinuation and serious AEs were 2% and 3%, respectively. Nausea (31%), constipation (11%), and vomiting (10%) were the most common AEs. AEs were mostly of mild (37%) or moderate (25%) severity and considered possibly or probably related to oliceridine in 33% of patients. Conclusion:Oliceridine IV for the management of moderate to severe acute pain was generally safe and well tolerated in the patients studied. ClinicalTrialsgov identifier:NCT02656875

SUq(2)SU_q(2) Lattice Gauge Theory

We reformulate the Hamiltonian approach to lattice gauge theories such that, at the classical level, the gauge group does not act canonically, but instead as a Poisson-Lie group. At the quantum level, it then gets promoted to a quantum group gauge symmetry. The theory depends on two parameters - the deformation parameter $\lambda$ and the lattice spacing $a$. We show that the system of Kogut and Susskind is recovered when $\lambda \rightarrow 0$, while QCD is recovered in the continuum limit (for any $\lambda$). We thus have the possibility of having a two parameter regularization of QCD.Comment: 26 pages, LATEX fil

Coadditive differential complexes on quantum groups and quantum spaces

A regular way to define an additive coproduct (or ``coaddition'') on the q-deformed differential complexes is proposed for quantum groups and quantum spaces related to the Hecke-type R-matrices. Several examples of braided coadditive differential bialgebras (Hopf algebras) are presented.Comment: 9 page

The question of EU legitimacy in the Social OMC peer review process

This paper examines the structural kand relational factors that affect perceptions of legitimacy in the EU's Social Open Method of Coordination, particularly in its peer review process. Using multi-level governance as its analytical framework, the paper uses network analysis to examine the actor networks and relations within the peer review process over time, and links this with different conceptions of input and throughput legitimacy, and the findings show that the peer reviews do not significantly feed into either input or throughput legitimacy. While input legitimacy is improved somewhat by the inclusion of additional actors in the policy process, these actors do not have a clear role to play and the peer reviews remain driven by traditional actors. In terms of throughput, the process does positively address issues of transparency, procedure and information provision, there is no clear path for translating these processes into an increase in perceptions of legitimacy

Eficiência agronômica do tratamento de sementes com fungicidas, inseticidas, micronutrientes, bioestimuladores, inoculantes e polímeros.

O tratamento de sementes com fungicidas, inseticidas, aplicação de micronutrientes, bioestimulantes e a inoculação com o Bradirhyzobium japonicum, juntamente com a utilização de sementes de qualidade, vem se tornando práticas indispensáveis para a produção de sementes de soja de qualidade. O objetivo deste trabalho foi avaliar a eficiência do tratamento de semente de soja com fungicidas, inseticidas, bioestimuladores, micronutrientes e polímeros, na emergência, população final, altura de plantas e rendimento da soja. Os experimentos foram instalados em dois locais, em solo já cultivado com soja, na fazenda experimental da Embrapa Soja e no Distrito Patrimônio Irerê, em Londrina-PR. Sementes da cultivar BRS 246 RR com vigor de 84% e viabilidade 94% (tetrazólio) e germinação (rolo de papel) 95 % foram tratadas com os seguintes produtos: Broadacre CMZ (fertilizante mineral misto em suspensão para uso no solo, contendo: Cu 23,6%, Mo 5,9%, Zn 47,2%); Booster ZnMo (extrato de algas enriquecido com 2,3% Mo e 3,5% Zn); Kelpak (extrato de algas) em combinação com os fungicidas Maxim XL (fludioxonil + metalaxyl) e Derosal Plus (carbendazin + thiram); inseticidas Cruiser 350 FS (tiametoxan) e Standak Top (piraclostrobina + tiofanato metílico + fipronil); Polímero Disco Ag Red e inoculante Cell Tech HC. O delineamento experimental foi em blocos casualizados com quatro repetições e a análise da variância foi efetuada pelo programa SASM, sendo as médias separadas pelo teste de Tukey a 5%. Os resultados demonstraram que adição de Broadacre CMZ aumenta o rendimento da soja. Porém são necessários mais estudos em diferentes locais e safras para confirmar esses resultados. Dentre os fungicidas testados, fluodioxonil (2,5g) + metalaxyl (1,0g) foi o menos eficiente

Maps between Deformed and Ordinary Gauge Fields

In this paper, we introduce a map between the q-deformed gauge fields defined on the GL$_{q}(N)$-covariant quantum hyperplane and the ordinary gauge fields. Perturbative analysis of the q-deformed QED at the classical level is presented and gauge fixing $\grave{a}$ la BRST is discussed. An other star product defined on the hybrid $(q,h)$% -plane is explicitly constructed .Comment: 10 page

Efeito do tratamento de sementes de soja com micronutrientes e bioestimulantes sobre o desenvolvimento de plântulas.

O objetivo deste trabalho foi o de avaliar os efeitos do tratamento de sementes de soja com micronutrientes (MN) e bioestimulantes (BE), sobre o desenvolvimento das plântulas. Os produtos com MN avaliados foram Broadacre CMZ, Broadacre Mn, Broadacre ZnCu e Maxi Zinc. Os BEs foram Kelpak e Booster. Foram conduzidos dois experimentos, um com a dose de 2,5 mL.kg-1 para cada produto e o outro com dose dobrada (5,0 mL.kg-1). Sementes da cultivar BRS 246RR foram utilizadas e submetidas aos testes de germinação, emergência de plântulas em areia, comprimento de plântula, de hipocótilo e de raiz, massa seca de plântula, de raiz e de parte aérea. Com relação aos testes de germinação e de comprimento de plântula, de hipocótilo e de raiz, os produtos Booster e Kelpak apresentaram baixa fitotoxicidade, caracterizada por encurtamento das plântulas, principalmente no sistema radicular. Em algumas situações, o Broadacre CMZ mostrou pouca fitotoxicidade. O Broadacre Mn propiciou melhor desenvolvimento das plântulas nesses testes. Efeitos positivos foram constatados também para o Broadacre CMZ e para o Maxi Zinc nas doses maiores. Nos testes de massa seca de plântula, raiz e parte aérea, foi verificado baixo efeito fitotóxico causado pelo Booster na dose maior. Entretanto, as fitotoxicidades aqui relatadas são consideradas aceitáveis e não se caracterizam num problema. Novamente, o Broadacre CMZ destacou-se pelo seu melhor desempenho quanto ao desenvolvimento das plântulas. De maneira geral, observou-se que os tratamentos com Broadacre CMZ, Mn e ZnCu e o Maxi Zinc propiciaram melhor desenvolvimento de plântulas, com maior massa seca em relação à testemunha

The fundamental pro-groupoid of an affine 2-scheme

A natural question in the theory of Tannakian categories is: What if you don't remember \Forget? Working over an arbitrary commutative ring $R$, we prove that an answer to this question is given by the functor represented by the \'etale fundamental groupoid \pi_1(\spec(R)), i.e.\ the separable absolute Galois group of $R$ when it is a field. This gives a new definition for \'etale \pi_1(\spec(R)) in terms of the category of $R$-modules rather than the category of \'etale covers. More generally, we introduce a new notion of "commutative 2-ring" that includes both Grothendieck topoi and symmetric monoidal categories of modules, and define a notion of $\pi_1$ for the corresponding "affine 2-schemes." These results help to simplify and clarify some of the peculiarities of the \'etale fundamental group. For example, \'etale fundamental groups are not "true" groups but only profinite groups, and one cannot hope to recover more: the "Tannakian" functor represented by the \'etale fundamental group of a scheme preserves finite products but not all products.Comment: 46 pages + bibliography. Diagrams drawn in Tik