The Thane of Glamis Had a Wife

The role of Lady Macbeth frequently appears more significant in dramatic performances than the text warrants. To consider the character of Lady Macbeth at a conference whose emphasis is upon performance should be to attempt to recapture the dramatic traditions of this often performed play. Every production incorporates an interpretation of Lady Macbeth. Many major English and American Shakespearean actresses have essayed the role: Mrs. Betterton, Mrs. Barry, Mrs. Pritchard, Sarah Siddons, Ellen Terry, Fanny Kremble, Charlotte Cushman, Mrs. Patrick Campbell, Judith Anderson, Vivian Leigh. The play was particularly a favorite vehicle for noted husband-and-wife acting teams. Playgoers like Pepys and Hazlitt continue the dramatic records that began with Simon Forman\u27s account of the 1610 performance of Macbeth he saw. Mrs. Siddons and other actresses have left memoirs. The Sargent portraits of Ellen Terry in her role, photographs and recordings of modern productions, reviews and criticisms, prompt books, costumes, and other memorabilia have helped to preserve past stage performances, but unlike the film performances, we can never capture the full nuances of these stage interpretations. The early years are particularly elusive. After eighty years of the Davenant text, Garrick on January 7, 1744, partially restored the folio text to the stage. It is to that full text and its sources that we must ultimately come if we are to comprehend the basis for the character of Lady Macbeth as it has been interpreted in so many different performances. Despite the attempts of L.C. Knights and others to discredit character study, Harry Levin acknowledges in the recent Riverside edition that character remains the central factor in our apprehension of Shakespeare. It is now possible to resist the temptation of character extraction and to accept the limitation of our knowledge of a character like Lady Macbeth to what she says, what she does, and what others in the play say about her

Soil conservation applications with C-band SAR

Soil conservation programs are becoming more important as the growing human population exerts greater pressure on this non-renewable resource. Indeed, soil degradation affects approximately 10 percent of Canada's agricultural land with an estimated loss of 6,000 hectares of topsoil annually from Ontario farmland alone. Soil loss not only affects agricultural productivity but also decreases water quality and can lead to siltation problems. Thus, there is a growing demand for soil conservation programs and a need to develop an effective monitoring system. Topography and soil type information can easily be handled within a geographic information system (GIS). Information about vegetative cover type and surface roughness, which both experience considerable temporal change, can be obtained from remote sensing techniques. For further development of the technology to produce an operational soil conservation monitoring system, an experiment was conducted in Oxford County, Ontario which investigated the separability of fall surface cover type using C-band Synthetic Aperture Radar (SAR) data

Real-time phase-shift detection of the surface plasmon resonance

We investigate a method to directly measure the phase of a laser beam reflected from a metallic film after excitation of surface plasmon polaritons. This method permits real time access to the phase information, it increases the possible speed of data acquisition, and it may thus prove useful for increasing the sensitivity of surface plasmon based sensors

Sneak preview of the Saskatchewan soil information system (SKSIS)

Non-Peer Reviewe

Inter-laboratory proficiency testing scheme for tumour next-generation sequencing in Ontario: A pilot study

Background A pilot inter-laboratory proficiency scheme for 5 Ontario clinical laboratories testing tumour samples for the Ontario-wide Cancer Targeted Nucleic Acid Evaluation (OCTANE) study was undertaken to assess proficiency in the identification and reporting of next-generation sequencing (NGS) test results in solid tumour testing from archival formalin-fixed, paraffin-embedded (FFPE) tissue. Methods One laboratory served as the reference centre and provided samples to 4 participating laboratories. An analyte-based approach was applied: each participating laboratory received 10 FFPE tissue specimens profiled at the reference centre, with tumour site and histology provided. Laboratories performed testing per their standard NGS tumour test protocols. Items returned for assessment included genes and variants that would be typically reported in routine clinical testing and variant call format (VCF) files to allow for assessment of NGS technical quality. Results Two main aspects were assessed: Technical quality and accuracy of identification of exonic variants Site-specific reporting practices Technical assessment included evaluation of exonic variant identification, quality assessment of the VCF files to evaluate base calling, variant allele frequency, and depth of coverage for all exonic variants. Concordance at 100% was observed from all sites in the technical identification of 98 exonic variants across the 10 cases. Variability between laboratories in the choice of variants considered clinically reportable was significant. Of the 38 variants reported as clinically relevant by at least 1 site, only 3 variants were concordantly reported by all participating centres as clinically relevant. Conclusions Although excellent technical concordance for NGS tumour profiling was observed across participating institutions, differences in the reporting of clinically relevant variants were observed, highlighting reporting as a gap where consensus on the part of Ontario laboratories is needed

Does the 1/f frequency-scaling of brain signals reflect self-organized critical states?

Many complex systems display self-organized critical states characterized by 1/f frequency scaling of power spectra. Global variables such as the electroencephalogram, scale as 1/f, which could be the sign of self-organized critical states in neuronal activity. By analyzing simultaneous recordings of global and neuronal activities, we confirm the 1/f scaling of global variables for selected frequency bands, but show that neuronal activity is not consistent with critical states. We propose a model of 1/f scaling which does not rely on critical states, and which is testable experimentally.Comment: 3 figures, 6 page

Saskatchewan Soil Information System (SKSIS)-The Launch!

Non-Peer Reviewe

Bi-cultural bi-national benchmarking and assessment of clinical reasoning in Obstetrics and Gynaecology

Published: 23/06/2016Background: The Script Concordance Test (SCT) is being increasingly used in professional development in clinical reasoning (CR) in postgraduate medicine. On-line delivery favours multi-institutional collaboration. Objectives: To establish if: 1) SCT questions developed in the French-speaking University of Montreal were readily adaptable for use in the English-speaking University of Adelaide 2) expert reference panels (ERP) from both institutions could be used interchangeably 3) student cohorts would perform similarly in the same test. Study Design: 82 SCT questions based on 27 clinical cases in Obstetrics and Gynaecology were developed in Montreal and run in a volunteer cohort of year 3 and year 4 medical students (n=154). Local faculty translated all questions, selecting 31 based on 17 clinical cases for use in summative examinations a year 5 student cohort in Adelaide (n=123). Results: Mean (SD) percentage scores using each ERP key were: 74.2 (6.4) versus 73.3 (6.9), p<0.001 for Adelaide students and 72.5 (7.8) versus 70.6 (8.8), p<0.001 for Montreal students. The correlation coefficients were ≥ 0.928 (p<0.001). Conclusions: Student cohorts performed similarly regardless of which ERP key was used. With appropriate editorial control, SCT’s can be effectively shared between French and English-speaking institutions located in different hemispheres. Potential advantages include the creation of an international database of assessment items, benchmarking and cost sharing.Paul Duggan, Patricia Monnier, Alphonse Roex, Marie-Josée Bédard, Bernard Charli

OCTANE (Ontario-Wide Cancer Targeted Nucleic Acid Evaluation): A Platform for Intraprovincial, National, and International Clinical Data-Sharing

Cancer is a genetic disease resulting from germline or somatic genetic aberrations. Rapid progress in the field of genomics in recent years is allowing for increased characterization and understanding of the various forms of the disease. The Ontario-wide Cancer Targeted Nucleic Acid Evaluation (octane) clinical trial, open at cancer centres across Ontario, aims to increase access to genomic sequencing of tumours and to facilitate the collection of clinical data related to enrolled patients and their clinical outcomes. The study is designed to assess the clinical utility of next-generation sequencing (ngs) in cancer patient care, including enhancement of treatment options available to patients. A core aim of the study is to encourage collaboration between cancer hospitals within Ontario while also increasing international collaboration in terms of sharing the newly generated data. The single-payer provincial health care system in Ontario provides a unique opportunity to develop a province-wide registry of ngs testing and a repository of genomically characterized, clinically annotated samples. It also provides an important opportunity to use province-wide real-world data to evaluate outcomes and the cost of ngs for patients with advanced cancer. The octane study is attempting to translate knowledge to help deliver precision oncology in a Canadian environment. In this article, we discuss the background to the study and its implementation, current status, and future directions