1,624 research outputs found
Device for Protection Against Transient and Temporary Overvoltage Including Limitation of the Specific Energy
An arrangement is presented which ensures protection against transient and line frequency overvoltage and limits the load on the consumer to a minimum even in case of transient currents. The arrangement consists of a special arrester in the shunt circuit, a fast switch in the series circuit as well as a control and measuring device. The design, mode of operation and parameters of the components of the arrangement are described based on different loads. The protective effect is discussed
Coping with refractory epilepsy
AbstractWe investigated the coping behaviour and its correlation with demographic and illness-related data, depression, locus of control and psychosocial adaptation in 40 patients with intractable epilepsy with primarily or secondarily generalized tonic–clonic seizures. Three standardized self-reporting questionnaires were applied, which are the Freiburg Questionnaire of Coping with Illness (FKV), the von Zerssen Depression Scale (D-S), and the IPC-questionnaire measuring generalized locus of control beliefs; the Social Interview Schedule (SIS), a semi-structured interview, was used to measure the psychosocial adaptation. Active, problem-focused and compliance strategies were predominantly used and regarded as most helpful. Hence, the epileptic patients use similar coping patterns reported in patients with other non life-threatening chronic diseases. The level of depression was moderate and in the range of other chronic somatic diseases. The use of coping patterns, which are regarded as maladaptive, was correlated with distinct depression, a small degree of internal locus of control beliefs and poor psychosocial adaption. These results indicate the possibility to improve psychosocial adjustment by supporting effective strategies
Controlling the stability transfer between oppositely traveling waves and standing waves by inversion-symmetry-breaking perturbations
The effect of an externally applied flow on symmetry degenerated waves
propagating into opposite directions and standing waves that exchange stability
with the traveling waves via mixed states is analyzed. Wave structures that
consist of spiral vortices in the counter rotating Taylor-Couette system are
investigated by full numerical simulations and explained quantitatively by
amplitude equations containing quintic coupling terms. The latter are
appropriate to describe the influence of inversion symmetry breaking
perturbations on many oscillatory instabilities with O(2) symmetry.Comment: 4 pages, 4 figure
Study of timing performance of Silicon Photomultiplier and application for a Cherenkov detector
Silicon photomultipliers are very versatile photo detectors due to their high
photon detection efficiency, fast response, single photon counting capability,
high amplification, and their insensitivity to magnetic fields. At our
institute we are studying the performance of these photo detectors at various
operating conditions. On the basis of the experience in the laboratory we built
a prototype of a timing Cherenkov detector consisting of a quartz radiator with
two mm MPPCs S10362-33-100C from Hamamatsu Photonics as
photodetectors. The MPPC sensors were operated with Peltier cooling to minimize
thermal noise and to avoid gain drifts. The test measurements at the DANE
Beam-Test Facility (BTF) at the Laboratori Nazionali di Frascati (LNF) with
pulsed 490 MeV electrons and the results on timing performance with Cherenkov
photons are presented.Comment: Conference proceedings of 12th Vienna Conference on Instrumentation
201
Inactivation of the Na,K-ATPase by radiation-induced free radicals Evidence for a radical-chain mechanism
AbstractFree radicals produced by water radiolysis were used to study the inactivation of the enzymatic activity of the Na,K-ATPase. A decrease of the activity to virtually zero with a mono-exponential dependence on the radiation dose was observed. The inactivation process is initiated by hydroxyl radicals. This was shown by the effect of appropriate radical scavengers such as t-butanol, formate and vitamin C. In all cases a significant increase in the characteristic D37 dose of inactivation was observed. Inactivation was found to show a so-called inverse dose-rate effect, i.e, the sensitivity of the enzyme to radical attack is increased if the dose rate is reduced. The data were found to agree with the relationship 1/D371̃/D1/2, which is known to be a strong indicator of a radical chain mechanism. This means that the inactivation, after initiation by single radicals, is amplified by a subsequent chain mechanism
Polimorfismos genéticos humanos y adicción a drogas de abuso: implicación del SNP C385 del gen FAAH en el consumo de riesgo de alcohol en jóvenes adultos
Tesis inédita de la Universidad Complutense de Madrid, Facultad de Psicología, leída el 05/11/2014Fac. de PsicologíaTRUEunpu
Pharmacokinetics of 1,25-dihydroxyvitamin D3 glycosides from Solanum glaucophyllum extract given in a rumen bolus on blood mineral profiles in dry pregnant dairy cows.
Providing tablets of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3), the biologically active metabolite of vitamin D3, in a rumen bolus may be used as prevention for periparturient hypocalcemia in dairy cows. This study investigated the pharmacokinetics of 1,25(OH)2D3 glycosides extracted from Solanum glaucophyllum (SGE) on blood serum 1,25(OH)2D3, Ca, P and Mg response in dry pregnant dairy cows. Boluses contained tablets of SGE which differed in their release properties (rapid release, slow release and combination) and galenics (200 μg uncoated, 300 μg and 500 μg uncoated or coated, 2 × 500 μg uncoated). Nineteen blood samples were collected from 29 cows between 96 h before and 336 h after bolus administration. Blood serum 1,25(OH)2D3, Ca and P increased between 12 h and 120 h, 12 h and 264 h and 24 h and 264 h, respectively. Highest values were reached at 30 h, 72 h and 120 h for 1,25(OH)2D3, Ca and P, respectively. Baseline values were then reached at 216 h for 1,25(OH)2D3 and 336 h for Ca and P. Concentration of Mg decreased between 24 h and 216 h, before reaching values comparable to baseline at 264 h. Highest Ca values were obtained with the combined rapid and slow release properties (500 μg) and there was no effect from coating on pharmacokinetics. In conclusion, the antepartum oral SGE bolus administration may be suitable for the prevention of periparturient hypocalcemia
Potential of a rumen bolus containing 1,25-dihydroxyvitamin D3 glycosides for the prevention of hypocalcaemia in primiparous and multiparous dairy cows
Periparturient hypocalcaemia is a widespread metabolic disorder in dairy cows. Clinical and subclinical cases occur primarily in multiparous (Multi) cows, but subclinical cases have also been reported in primiparous (Primi) cows. A preventive strategy was investigated by administering the physiologically active vitamin D3 metabolite, 1,25-dihydroxyvitamin D3 (1,25-dihydroxycholecalciferol, 1,25(OH)2D3) as a rumen bolus. The bolus contained tablets of 1,25(OH)2D3 glycoside extract from Solanum glaucophyllum (SGE), releasing SGE over several days. The aim was to study the effect of a bolus containing 0 (C) or 500 µg (SGE) of 1,25(OH)2D3 on 1,25(OH)2D3 and mineral status in periparturient cows up to three weeks into lactation and on colostrum, milk and calves' blood mineral contents. The bolus was administered three to four days prior to expected calving to Primi and Multi cows fed a herbage-based diet (dietary cation-anion difference of +522 mEq/kg DM). One C or SGE bolus was applied to 12 Primi and 12 Multi cows. Blood was regularly sampled (and selected a posteriori for antepartum samples) in regard to the actual calving day (d0), immediately prior to bolus application and at day -2, 0.5, 1, 1.5, 2, 4, 8, 11, 15, 18 and 22. Additional samples included urine (at bolus application, d0.5 and d2), colostrum, milk samples (weekly) and calves' blood (d2). Blood serum 1,25(OH)2D3 increased between d0.5 and d2 in Primi-SGE, but remained unchanged in Primi-C, as did parathyroid hormone (PTH) and Ca in all Primi. Urinary Ca of Primi-SGE was increased on d2, indicating regulation of Ca excess. Three Multi-C cows with confirmed clinical hypocalcaemia needed treatment and thus were excluded from the dataset and replaced. Blood serum 1,25(OH)2D3 and PTH increased while Ca dropped by 40% between d0.5 and d2 in Multi-C, whereas 1,25(OH)2D3, Ca and PTH remained unchanged in Multi-SGE. Blood serum carboxyterminal telopeptide of type I collagen was higher in Primi than in Multi and increased with time, except in Primi-C. Mineral contents in colostrum, milk and blood serum of calves were not influenced to a relevant degree. In conclusion, Primi-C did not, in contrast to Multi-C, develop subclinical hypocalcaemia (<2.0 mmol Ca/l). Prevention of hypocalcaemia with one SGE bolus applied three to four days prior to expected calving was successful in maintaining blood Ca within normal range in Multi over the critical first two days and up to the first three weeks of lactation, without any observed detrimental effects on cows or calves
SrCu_2(BO_3)_2 - a Two Dimensional Spin Liquid
We study an extended Shastry-Sutherland model for SrCu_2(BO_3)_2 and analyze
the low lying parts of the energy spectrum by means of a perturbative unitary
transformation based on flow equations. The derivation of the 1-magnon
dispersion (elementary triplets) is discussed. Additionally, we give a
quantitative description (symmetries and energies) of bound states made from
two elementary triplets. Our high order results allow to fix the model
parameters for SrCu_2(BO_3)_2 precisely: J_1=6.16(10)meV, x:=J_2/J_1=0.603(3),
J_\perp=1.3(2)meV. To our knowledge this is the first quantitative treatment of
bound states in a true 2d model.Comment: 4 pages, 3 figures, Proceeding paper of the HFM2000 conference in
Waterloo, Canada, Jun 200
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